Abstract: The present disclosure relates to antisense oligonucleotides, which target CAMK2D mRNA in a cell, leading to reduced expression of CAMK2D protein. Reduction of CAMK2D protein expression is beneficial for the treatment of certain medical disorders, e.g., cardiovascular-related diseases or disorders.

Abstract: A commercial vehicle used for parcel delivery is installed with a control module. The control module communicates wirelessly with a transmitter to give control to the vehicle operator. The vehicle operator can access the vehicle's cargo compartment through the bulkhead door and/or the rear door solely by using the transmitter as opposed to manually actuating the door latch. A door actuator is added to the bulkhead door such that when the bulkhead door is wirelessly actuated the door opens without operator assistance, and the process of the door opening does not damage the vehicle. Additionally, the vehicle operator can initiate the control module to allow a push-button start and stop of the vehicle's ignition system. Such elements contribute to time savings and cost savings for parcel delivery operators.

Abstract: A versioned file storage system (VFS) and method for operating and using the same is disclosed. In an aspect, a mechanism is provided wherein a first VFS interface unit coupling the VFS to a local data storage system is replaced with a second VFS interface unit in a coordinated procedure for taking the first unit offline, making a reliable snapshot of its data and cache structure in the VFS, and loading the same data and cache structure into the second VFS interface brought online. The first and second VFS interfaces transfer the necessary data to achieve the switch through respective side-loading daemons running in each interface. Clients in the local data storage system experience minimal interruption of services in the VFS.

Abstract: Provided are water treatment systems and methods of treating water that include separating dissolved salts from a feed stream using an organic solvent brine stream. For example, described are water treatment systems comprising: an electrodialysis device comprising an inlet feed stream, an inlet brine stream, an outlet product stream, and an outlet brine stream; and a precipitation tank comprising an inlet stream and an outlet stream, wherein the inlet stream of the precipitation tank comprises the outlet brine stream of the electrodialysis device, and the inlet brine stream of the electrodialysis device comprises the outlet stream of the precipitation tank, and wherein inlet brine stream and outlet brine stream comprises an organic solvent.

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK ?) and diacylglycerol kinase zeta (DGK?), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

Abstract: A vehicle that includes a door, handle, shaft, and a latch assembly is provided. The latch assembly is coupled to the door to selectively secure the door. The latch assembly includes a security tether configured to prevent the shaft from moving the pawl when the lock lever is located in the locked condition.

Abstract: The present disclosure relates to antisense oligonucleotides, which target CAMK2D mRNA in a cell, leading to reduced expression of CAMK2D protein. Reduction of CAMK2D protein expression is beneficial for the treatment of certain medical disorders, e.g., cardiovascular-related diseases or disorders.

Abstract: Provided are water treatment systems and methods of treating water that include separating boron and concentrating lithium. For example, described are water treatment systems comprising: a first phase comprising a first plurality of electrodialysis units configured to separate boron from a feed stream, and a second phase comprising a second plurality of electrodialysis units, wherein the feed stream of at least one electrodialysis unit of the second plurality of electrodialysis units comprises an outlet brine stream of at least one electrodialysis unit of the first plurality of electrodialysis units, and wherein the second plurality of electrodialysis units are configured to produce a product brine stream achieving 90-99% lithium recovery.

Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.

Abstract: In one embodiment, a vehicle platform comprises a central body that can support one or more implement configurations, such as sprayer booms, or planting row units. A plurality of adjustable legs extends downward from the central body. Each adjustable leg has a corresponding leg actuator to adjust a respective vertical height of each adjustable leg. Each adjustable leg supports the central body. Planting row units are supported by or suspended from the central body.

Abstract: A commercial vehicle used for parcel delivery is installed with a control module. The control module communicates wirelessly with a transmitter to give control to the vehicle operator. The vehicle operator can access the vehicle's cargo compartment through the bulkhead door and/or the rear door solely by using the transmitter as opposed to manually actuating the door latch. A door actuator is added to the bulkhead door such that when the bulkhead door is wirelessly actuated the door opens without operator assistance, and the process of the door opening does not damage the vehicle. Additionally, the vehicle operator can initiate the control module to allow a push-button start and stop of the vehicle's ignition system. Such elements contribute to time savings and cost savings for parcel delivery operators.

Abstract: A pickup truck that includes a cab section located in front of a bed section is provided. The pickup truck comprises a tonneau cover that covers the bed section. The tonneau cover includes a plurality of panel sections; and wherein each of the plurality of panel sections is movable with respect to each other to allow access to, or conceal the bed section underneath. At least one prop rod assembly includes a longitudinally extending first rod having a first end and a second end. The first end of the longitudinally extending first rod is pivotably and removably coupled to a side rail that is secured to the first side of the bed section, and the second end of the longitudinally extending first rod is located opposite the first end and pivotably coupled to the first latch assembly of the third panel section.

Abstract: The present disclosure is directed an ion exchange membrane that has an increased affinity for a specific ionic species. The ion exchange membranes disclosed herein include ionophores that can increase ion-selectivity. These ion exchange membranes can be incorporated to various ion-exchange systems or devices that can selectively separate ions of value.

Abstract: A latching assembly for use on a pick-up truck, and particularly on a truck bed cover configured to sit over a truck bed section is provided. The latching assembly includes an electronic release assembly and a mechanical override system. An electronic release assembly includes a first rod coupled to a first electronic actuator and a second rod coupled to a second electronic actuator. The electronic release assembly also includes a first electronic actuator that selectively moves the first latch catch and the second electronic actuator that selectively moves the second latch catch. A switch is engaged to send a signal to the first and second electronic actuators to cause the first and second latch catches to disengage from the truck bed section. The first and second rods and the first and second electronic actuators also serve as part of a mechanical override system that selectively unlatches at least a portion of the truck bed cover from the truck bed section.

Abstract: Performance based delivery of content to an audience member. A network of audience member information collection domains provide information about audience members. A profiled audience member may belong to a network segment. Delivery of an advertisement to the profiled audience member is accommodated based upon membership in the network segment and performance criteria. The performance criteria may be configured to benefit a publisher, such as by maximizing revenue. Allocating revenue based upon the collection of data used to target audience members is also provided.

Abstract: A pickup truck that includes a cab section located in front of a bed section is provided. The pickup truck comprises a tonneau cover that covers the bed section. The tonneau cover includes a plurality of panel sections; and wherein each of the plurality of panel sections is movable with respect to each other to allow access to, or conceal the bed section underneath. At least one prop rod assembly includes a longitudinally extending first rod having a first end and a second end. The first end of the longitudinally extending first rod is pivotably and removably coupled to a side rail that is secured to the first side of the bed section, and the second end of the longitudinally extending first rod is located opposite the first end and pivotably coupled to the first latch assembly of the third panel section.

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK?) and diacylglycerol kinase zeta (DGK?), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives a first set of address data that describes a first geographic location. The program further determines a first set of geo-location coordinates based on the first set of address data. The program also determines a second set of geo-location coordinates based on the first set of geo-location coordinates. The program further determines a second set of address data based on the second set of geo-location coordinates.

Abstract: A method for treating plants comprises estimating a growth state or maturity state of a plant based on a planting date, a current date and the crop type of the plant. A root zone estimator or data processor estimating a size, diameter or radius of a root zone of the plant based on the determined growth state or maturity state. The data processor adjusts a lateral offset of a distribution pattern of a crop input or nutrient from at least one nutrient knife based on the size, diameter or radius of the root zone and safety zone about the root zone, where the at least one nutrient knife tracks a path outside of or bounded by the root zone.

Abstract: The invention provides a display interface in a social networking system that enables the presentation of information related to a user in a timeline or map view. The system accesses information about a user of a social networking system, including both data about the user and social network activities related to the user. The system then selects one or more of these pieces of data and/or activities from a certain time period and gathers them into timeline units based on their relatedness and their relevance to users. These timeline units are ranked by relevance to the user, and are used to generate a timeline or map view for the user containing visual representations of the timeline units organized by location or time. The timeline or map view is then provided to other users of the social networking system that wish to view information about the user.