Abstract: Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are provided.

Abstract: A system includes a controller programmed to monitor an oxidation state of a three-way catalyst (TWC) assembly coupled to a combustion engine. The controller is programmed to receive signals representative of oxygen (O2) concentration in a fluid both upstream of an inlet and downstream of an outlet of the TWC assembly, to receive a signal representative of the measured O2 storage of the TWC assembly from at least one radio frequency (RF) probe disposed within the TWC assembly, to utilize a model to generate an estimated O2 storage of the TWC assembly based at least on the O2 concentration in the fluid both upstream and downstream of the TWC assembly, to compare the estimated O2 storage to the measured O2 storage, and to output a control action for the TWC assembly based at least on the comparison of the estimated O2 storage to the measured O2 storage.

Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): (structurally represented) or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.

Abstract: Described herein are recombinant polynucleotide-binding polypeptides, recombinant fusion proteins made with the described polynucleotide-binding polypeptides, methods of using the described recombinant polynucleotide-binding polypeptides and recombinant fusion proteins to modify genomic DNA of cells and, in some embodiments, create recombinant cells. Methods are also provided herein for genetically modifying a neuronal stem cell. Methods are also provided for treating a neurological disorder in a subject that include the administration of genetically modified neuronal stem cells produced by the methods disclosed herein.

Abstract: Functionalized F-POSS compounds comprising synthetic blends of at least two feedstocks that produce a distribution of fluorinated polyhedral oligomeric silsesquioxane molecule structures and/or functional groups.

Abstract: The present invention relates a process for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, which process comprises converting a compound of formula (IV): or a pharmaceutically acceptable salt thereof, into the compound of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion phenotype. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab.

Abstract: A digital document display device capable of displaying a document, retrieving updates, sharing locally with other devices, managing document displays in other digital document display devices in proximity, etc. A e-paper based display unit of the digital document display device is configured to read and display the display image. A motion detector unit helps detect human motion, so that the digital document display device may be set to a low power mode, or powered off, etc. if no humans are detected in the vicinity. A renewable energy power unit is also provided.

Abstract: An electronic device, a method, and a computer-readable medium. The electronic device includes a circuitry configured to receive a radio communication signal for another device, configured to determine, based on the radio communication signal, one or more features that can reflect the difference between an uplink transmission mode and a downlink transmission mode, and configured to judge whether the radio communication signal is for the uplink transmission or the downlink transmission according to the one or more features.

Abstract: Provided herein are assays and in vitro methods to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility. Also provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product.

Abstract: A method of operation of a navigation system includes: receiving a destination; generating a route to the destination; and generating a non-native dynamic navigation based on the route for displaying on a device.

Abstract: The subject matter described herein includes methods, systems, and computer readable media for simulating per-UE Doppler shifts. One exemplary method includes generating uplink signals to be transmitted from a plurality of different simulated UEs to an air interface device under test. The method further includes applying per-UE Doppler shifts to the signals, wherein applying per-UE Doppler shifts includes applying different Doppler shifts to at least some of the signals. The method further includes transmitting the signals to the air interface device under test.

Abstract: A method for voltage level shifting comprises several steps. A data signal in a first voltage domain is received by a voltage level shifter. The received data signal is shifted to a second voltage domain by the voltage level shifter, where the voltage level shifter is configured as a function of the shifted data signal. The shifted data signal is outputted.

Abstract: Disclosed is a structure for reducing noise of a ventilating fan. The structure includes an orifice plate fixed on a scroll casing and is shaped to be an annular and semi-surrounding hollow structure in order to match with the shape of an air inlet of the scroll casing, and to cover only the air inlet of the scroll casing. The noise generated by an air blower of the ventilating fan can be directed along a bell mouth of the scroll casing of the ventilating fan after being emitted from the air inlet of the scroll casing, and then can be smoothly sucked by the orifice plate. The sucked-in noise can repeatedly collide with the orifice plate and be diffused, thereby the energy being gradually weakened and the sound pressure thereof being decreased.

Abstract: Techniques are provided for mitigating the effects of slow or no drain devices on a fabric. One or more of the described embodiments can be used alone or in combination to address problems associated with inter-switch link blocking and to address the situation where flows which are not associated with slow/no drain devices suffer the negative impacts of slow or no drain devices on a fabric.

Abstract: Various implementations of hybrid ceramic faceplates for substrate processing showerheads are provided. The hybrid ceramic showerhead faceplates may include an electrode embedded within the ceramic material of the faceplate, as well as a pattern of through-holes. The electrode may be fully encapsulated within the ceramic material with respect to the through-holes. In some implementations, a heater element may also be embedded within the hybrid ceramic showerhead faceplate. A DC voltage source may be electrically connected with the hybrid ceramic showerhead faceplate during use. The hybrid ceramic faceplates may be easily removable from the substrate processing showerheads for easy cleaning and faceplate replacement.

Abstract: The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

Abstract: A light field imaging system captures different images provide views that are shifted by sub-pixel amounts relative to one another. These views can be combined to produce a higher resolution digital image of the object.

Abstract: The present subject matter discloses systems and methods for managing patents in an enterprise. In one implementation, the method includes generating a package testing equation utilizing a interpolation constant and a secondary input data and computing one or more of a stress, a strain, a damage coefficient, collective stress collective strain and collective damage coefficient utilizing the package testing equation and the secondary input data, wherein the damage coefficient is indicative of the damage sustained by the package. Further, evaluating the package design based one or more of a stress, a strain, a damage coefficient, collective stress collective strain and collective damage coefficient and a failure identification matrix to enable optimized package design.

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.