Abstract: An apparatus is provided which comprises: a first power supply rail to provide a first power supply; second and third power supply rails to provide second and third power supplies, respectively, wherein a voltage level of the first power supply is higher than a voltage level of each of the second and third power supplies; a first driver circuitry coupled to the first power supply rail and the second power supply rail; a second driver circuitry coupled to the third power supply rail, and coupled to the first driver circuitry; and a stack of transistors of N conductivity type coupled to the first power supply rail, and to the second driver circuitry.

Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human beta-2 microglobulin gene. The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified T cells having reduced cell-surface expression of beta-2 microglobulin.

Abstract: The present disclosure provides novel co-stimulatory domains useful in genetically-modified cells to promote cell proliferation and/or promote cytokine secretion after antigen recognition. For example, disclosed herein are genetically-modified cells comprising a chimeric antigen receptor or an inducible regulatory construct incorporating the co-stimulatory domains disclosed herein. Also disclosed herein are plasmids and viral vectors comprising a nucleic acid sequence encoding the co-stimulatory domains, and methods of administering compositions comprising the novel co-stimulatory domains to subjects in order to reduce the symptoms, progression, or occurrence of disease, such as cancer.

Abstract: The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.

Abstract: Provide a door latch device that allowing a childproof-double-lock mechanism is simplified and the size of the door latch device is miniaturized. While supporting a childproof lever and a double lock lever by a support shaft, coordinating the childproof lever and the double lock lever by an interlocking means and for moving the double lock lever in the direction of a double-lock position in conjunction with the childproof lever and the double lock lever move to the 3rd position from the 2nd position where is a childproof lock position.

Abstract: The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.

Abstract: Techniques are disclosed for advantageously forecasting an inventory of a product having a particular duration (e.g., video content). The technique can include determining the particular configuration (e.g., maximum number of impressions, maximum amount of time permitted) of breaks identified within an impression log. Based on the number of breaks and the configurations of the breaks, the technique can forecast a future inventory of the product. In some implementations, the disclosed technique can identify an amount of a previous break that was not filled with video content. These forecasts can enable product sellers to better communicate with their customers, negotiate supply contracts, price their products, plan for business operations, etc.

Abstract: The present disclosure provides novel co-stimulatory domains useful in genetically-modified cells to promote cell proliferation and/or promote cytokine secretion after antigen recognition. For example, disclosed herein are genetically-modified cells comprising a chimeric antigen receptor or an inducible regulatory construct incorporating the co-stimulatory domains disclosed herein. Also disclosed herein are plasmids and viral vectors comprising a nucleic acid sequence encoding the co-stimulatory domains, and methods of administering compositions comprising the novel co-stimulatory domains to subjects in order to reduce the symptoms, progression, or occurrence of disease, such as cancer.

Abstract: An article that includes a structured substrate having a macro-porous structure that defines a plurality of pores, and a metallic nano-crystalline coating on at least a portion of the structured substrate, where the metallic nano-crystalline coating defines an average grain size less than about 20 nanometers.

Abstract: The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.

Abstract: Techniques are disclosed for advantageously forecasting an inventory of a product having a particular duration (e.g., video content). The technique can include determining the particular configuration (e.g., maximum number of impressions, maximum amount of time permitted) of breaks identified within an impression log. Based on the number of breaks and the configurations of the breaks, the technique can forecast a future inventory of the product. In some implementations, the disclosed technique can identify an amount of a previous break that was not filled with video content. These forecasts can enable product sellers to better communicate with their customers, negotiate supply contracts, price their products, plan for business operations, etc.

Abstract: An apparatus is provided which comprises: a first circuitry to sample a first input signal to generate a first sampled signal, and to sample a second input signal to generate a second sampled signal, wherein the first input signal comprises data; a second circuitry to receive the first sampled signal and the second sampled signal, and to generate a first pair of differential signals; an offset cancellation circuitry to cancel or reduce an offset in the first pair of differential signals; and a latch to receive the first pair of differential signals subsequent to the cancellation or reduction of the offset, and to output a second pair of differential signals, wherein the second pair of differential signals is indicative of the data.

Abstract: A leg for attachment to a main body of a taxidermy mannequin includes first, second, and third portions, each having first and second ends. The first end of the first portion includes a connector for coupling to the main body. The first end of the second portion is connected to the second end of the first portion to form a first joint. At least one of the first or second portions has a first cut-away section proximate the first joint with a reduced thickness. The first end of the third portion is connected to the second end of the second portion to form a second joint. At least one of the second or third portions has a second cut-away section proximate the second joint with a reduced thickness.

Abstract: A door latch device having a motor cover for covering a motor and connection parts thereof, wherein the motor cover in a size for covering the motor from a vehicle interior side is formed to a switch member housed in a casing, connection parts of the motor are respectively connected to conductive members of the switch member on a vehicle-exterior-side side face of the motor cover, and the motor 44 and the connection parts thereof are covered with the motor cover.

Abstract: An apparatus is provided, where the apparatus includes a plurality of components; a first circuitry to generate a clock signal, and to supply the clock signal to the plurality of components; a second circuitry to estimate, for each of two or more components of the plurality of components, a corresponding duty cycle of the clock signal received at the corresponding component, wherein two or more duty cycles corresponding to the two or more components are determined; a third circuitry to determine an average of the two or more duty cycles; and a fourth circuitry to correct a duty cycle of the clock signal generated by the first circuitry, based at least in part on the average.

Abstract: An apparatus is provided which comprises: a first power supply rail to provide a first power supply; second and third power supply rails to provide second and third power supplies, respectively, wherein a voltage level of the first power supply is higher than a voltage level of each of the second and third power supplies; a first driver circuitry coupled to the first power supply rail and the second power supply rail; a second driver circuitry coupled to the third power supply rail, and coupled to the first driver circuitry; and a stack of transistors of N conductivity type coupled to the first power supply rail, and to the second driver circuitry.

Abstract: An apparatus is provided which comprises: a first circuitry to sample a first input signal to generate a first sampled signal, and to sample a second input signal to generate a second sampled signal, wherein the first input signal comprises data; a second circuitry to receive the first sampled signal and the second sampled signal, and to generate a first pair of differential signals; an offset cancellation circuitry to cancel or reduce an offset in the first pair of differential signals; and a latch to receive the first pair of differential signals subsequent to the cancellation or reduction of the offset, and to output a second pair of differential signals, wherein the second pair of differential signals is indicative of the data.

Abstract: A door latch device which allows shared use of a connector for use in door latch devices equipped with standard electric components and a connector for use in door latch devices equipped with special electric components in addition to the standard electric components, thereby achieving an increase in the efficiency of the work of connecting to an external connector and a reduction in costs. A connector (32) of a standard switch plate (26) has a coupling hole (51) which penetrates, in the connecting direction of the external connector, a portion having no standard connecting terminals (304). The coupling hole (51) can be fitted with another switch plate (46) that allows the passage of electric current through electric components different than the standard electric components.

Abstract: An endless fabric belt having a seam region, the seam region comprising: a) machine direction (MD) threads; b) cross-direction (CD) threads interwoven with the MD threads; and c) termination zones distributed throughout the entire seam region, with each termination zone comprising two ends of an MD thread; wherein: a plurality of the CD threads are fusible, with the fusible (F) and non-fusible (N) CD threads distributed in a pattern throughout the seam region such that in a repeating unit of the pattern, the ratio of F threads to CD threads is at most 0.75; and a plurality of the termination zones further comprise at least one fusible CD thread attached to the MD thread in the termination zone.

Abstract: The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.