Abstract: In an aspect, an apparatus for procedural training is presented. An apparatus includes at least a processor and a memory communicatively connected to at least a processor. A memory contains instructions configuring at least a processor to receive optical data from a sensor comprising a machine vision system in electronic communication with the at least a processor, wherein the machine vision system is configured to identify at least one object within optical data. At least a processor is configured to determine a procedural performance parameter as a function of optical data wherein determining the procedural performance parameter comprises classifying the at least one object within optical data to an optical data category using an optical data classifier. At least a processor is configured to compare a procedural performance parameter to a procedural performance threshold. At least a processor is configured to display procedural training feedback through a display unit as a function of a comparison.

Abstract: A controller for controlling a power stage having a plurality of phases is presented. The controller generates a control signal; sends the control signal to the plurality of phases via a first link; receives from each phase a feedback signal via a second link; sums the plurality of feedback signals and derives an average current per phase.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: A controller for controlling a power stage having one or more phases is presented. The controller includes a reference circuit that generates a reference signal; a ramp generator generating a feedback ramp signal based on a feedback signal of the power stage; and a modulator generating a control signal for controlling at least one phase of the power stage. The control signal may include a series of pulses in which each pulse is associated with a corresponding phase of the power stage.

Abstract: A power converter controller is presented. The controller includes a ramp generator for generating a ramp signal and a ramp adjuster. The ramp adjuster compares a feedback signal of the converter with a threshold signal to obtain a comparison signal, and to adjust an amplitude of the ramp signal based on the comparison signal. Also presented is a constant on time COT power converter including the above controller.

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

Abstract: Improved duct modeling using an improved duct definition interface includes receiving, from an automated duct definition interface, a plurality of duct definition parameters associated with a duct; in response to the receiving, building a duct definition database based at least on the plurality of duct definition parameters, the duct definition database further comprising a plurality of operational parameters associated with the duct; generating a duct model associated with the duct based at least on the duct definition database; and communicating the duct model to a duct modeling application for rendering.

Abstract: The present invention provides a method for treating alopecia using certain pharmaceutically active pyrrolo[2,3-d]pyrimidinyl acrylamides having the structure: or a pharmaceutically acceptable salt thereof, as set forth in the Description.

Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Abstract: In an aspect, an apparatus for procedural training is presented. An apparatus includes at least a processor and a memory communicatively connected to at least a processor. A memory contains instructions configuring at least a processor to receive optical data from a sensor comprising a machine vision system in electronic communication with the at least a processor, wherein the machine vision system is configured to identify at least one object within optical data. At least a processor is configured to determine a procedural performance parameter as a function of optical data wherein determining the procedural performance parameter comprises classifying the at least one object within optical data to an optical data category using an optical data classifier. At least a processor is configured to compare a procedural performance parameter to a procedural performance threshold. At least a processor is configured to display procedural training feedback through a display unit as a function of a comparison.

Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Abstract: A computer-implemented method includes controlling an instrument to measure a fluorescence emission spectrum of a sample including a first peak emission wavelength and at least a second peak emission wavelength, emitted in response to an excitation wavelength and controlling the instrument to measure an absorbance obtained at the excitation wavelength of the sample. The method may include determining, using the computer, a ratio of the measurements at either the second peak emission wavelength, or a sum of measurements at a plurality of peak emission wavelengths including at least the first peak emission wavelength and the second peak emission wavelength, to the first peak emission wavelength, and calculating, using the computer, a value for a quality parameter based on a combination of at least the ratio and the absorbance measurement. The method may include controlling an associated process based on the quality parameter.

Abstract: Disclosed are methods and systems for automatic generation and distribution of curbside map data. A server receives municipal regulation data from an external source, and processes the municipal regulation data to generate curbside map data. The server also transmits a message conveying at least a portion (e.g. relevant portion based on request) of the curbside map data to a client computing device. By obtaining and processing the municipal regulation data, the curbside map data can be generated and distributed without time consuming and error prone disadvantages of manual surveying.

Abstract: In an aspect, an apparatus for procedural training is presented. An apparatus includes at least a processor and a memory communicatively connected to at least a processor. A memory contains instructions configuring at least a processor to receive optical data from a sensor in electronic communication with the at least a processor. At least a processor is configured to determine a procedural performance parameter as a function of optical data. At least a processor is configured to compare a procedural performance parameter to a procedural performance threshold. At least a processor is configured to display procedural training feedback through a display unit as a function of a comparison.

Abstract: Disclosed are methods and systems for automatic generation and distribution of curbside map data. A server receives municipal regulation data from an external source, and processes the municipal regulation data to generate curbside map data. The server also transmits a message conveying at least a portion (e.g. relevant portion based on request) of the curbside map data to a client computing device. By obtaining and processing the municipal regulation data, the curbside map data can be generated and distributed without time consuming and error prone disadvantages of manual surveying.

Abstract: The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drug conjugates, and the resulting antibody drug conjugates made with components having heteroaryl sulfone-based conjugation handles.

Abstract: In an aspect, an apparatus for procedural training is presented. An apparatus includes at least a processor and a memory communicatively connected to at least a processor. A memory contains instructions configuring at least a processor to receive optical data from a sensor in electronic communication with the at least a processor. At least a processor is configured to determine a procedural performance parameter as a function of optical data. At least a processor is configured to compare a procedural performance parameter to a procedural performance threshold. At least a processor is configured to display procedural training feedback through a display unit as a function of a comparison.

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Abstract: A dashboard interface may be displayed on a lab instrument to provide aggregate status information from a plurality of other interfaces organized into a single interface. The aggregate status information may be viewed by a nearby user of the lab instrument, and selecting portions of the information via a touchscreen display will navigate directly to a subsequent interface that may be used to view additional information or make configuration changes relating to the selected information. The dashboard may be used as a screensaver on a lab instrument when the instrument is not in use, or may be navigated to by an active user of a lab instrument, or both.