Abstract: A publish and subscribe architecture can be utilized to manage records, which can be used to accomplish the various functional goals. At least one template having definitions for managing production and consumption of data within an unconfigured group of computing resources is maintained. Records organized by topic collected from multiple disparate previously configured producers are utilized to initiate configuration of the unconfigured group of computing resources. Records within a topic are organized by a corresponding topic sequence. A first portion of the computing resources are configured as consumers based on the at least one template. The consumers to consume records at a pace independent of record production. A second portion of the computing resources are configured as producers based on the at least one template. The producers to produce records at a pace independent of record consumption.

Abstract: A dashboard interface may be displayed on a lab instrument to provide aggregate status information from a plurality of other interfaces organized into a single interface. The aggregate status information may be viewed by a nearby user of the lab instrument, and selecting portions of the information via a touchscreen display will navigate directly to a subsequent interface that may be used to view additional information or make configuration changes relating to the selected information. The dashboard may be used as a screensaver on a lab instrument when the instrument is not in use, or may be navigated to by an active user of a lab instrument, or both.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: Aspects of the present disclosure relate to a terminal fastener for electrically connecting a battery terminal associated with at least part of a traction battery to an electrical circuit of a vehicle, the terminal fastener comprising: a terminal engaging portion configured to engage with the battery terminal; a tool receiving portion configured to receive a tool to fasten the terminal engaging portion to the battery terminal; and insulation configured to cover at least part of the terminal fastener.

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

Abstract: The present invention provides, in part, compounds of Formula I, or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: (R1)a, (R2)b, (R3)c, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Abstract: The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone-based conjugation handles.

Abstract: Methods and systems are provided for a turbocharger. In one example, a system comprises a compressor housing clamped to a bearing housing via a clamp ring. The clamp ring may be configured to at least partially detach the compressor and allow the compressor to rotate and/or shift in response to a force.

Abstract: Disclosed are methods and systems for automatic generation and distribution of curbside map data. A server receives municipal regulation data from an external source, and processes the municipal regulation data to generate curbside map data. The server also transmits a message conveying at least a portion (e.g. relevant portion based on request) of the curbside map data to a client computing device. By obtaining and processing the municipal regulation data, the curbside map data can be generated and distributed without time consuming and error prone disadvantages of manual surveying.

Abstract: A disposable stylus is described. The stylus may include a stem having a grip region and an end having a tip. This stylus may include a conductive path between the grip region and the tip having an electrical conductivity that is greater than a predefined amount. During use, a user may grasp or hold the grip region of the stylus. Then, while maintaining contact with the stylus, the user may touch or contact a surface of, e.g., a touch-sensitive display at a contact point using the tip. The stylus may form a conductive path between the user's fingers and the surface. This conductive path may allow the user to transfer or redistribute electric charge to or in the touch-sensitive display, so that a location of the contact point may be determined by the touch-sensitive display while protecting the user from pathogens on or associated with the surface.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylam ides and analogues thereof, having the structure: or a pharmaceutically acceptable salt thereof, as set forth in the Description. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: A computer-implemented method includes controlling an instrument to measure a fluorescence emission spectrum of a sample including a first peak emission wavelength and at least a second peak emission wavelength, emitted in response to an excitation wavelength and controlling the instrument to measure an absorbance obtained at the excitation wavelength of the sample. The method may include determining, using the computer, a ratio of the measurements at either the second peak emission wavelength, or a sum of measurements at a plurality of peak emission wavelengths including at least the first peak emission wavelength and the second peak emission wavelength, to the first peak emission wavelength, and calculating, using the computer, a value for a quality parameter based on a combination of at least the ratio and the absorbance measurement. The method may include controlling an associated process based on the quality parameter.

Abstract: A server has a processor and a memory connected to the processor. The memory stores instructions executed by the processor to receive broadcast reports from a network, where each broadcast report includes an account identifier, a group identifier, a data stream identifier and a value. Each broadcast report is stored in a database as raw data. A request for information in the database is received. In response to the request, the raw data is altered in accordance with a pre-defined data transformation to produce transformed data. A first visualization of the transformed data associated with a first data stream identifier of a first group identifier is rendered. A second visualization of the transformed data associated with a second data stream identifier of the first group identifier is rendered. The first visualization is supplied in conjunction with the second visualization in response to the request.

Abstract: A computer-implemented method includes controlling an instrument to measure a fluorescence emission spectrum of a sample including a first peak emission wavelength and at least a second peak emission wavelength, emitted in response to an excitation wavelength and controlling the instrument to measure an absorbance obtained at the excitation wavelength of the sample. The method may include determining, using the computer, a ratio of the measurements at either the second peak emission wavelength, or a sum of measurements at a plurality of peak emission wavelengths including at least the first peak emission wavelength and the second peak emission wavelength, to the first peak emission wavelength, and calculating, using the computer, a value for a quality parameter based on a combination of at least the ratio and the absorbance measurement. The method may include controlling an associated process based on the quality parameter.

Abstract: Methods and systems are provided for a turbocharger. In one example, a system comprises a compressor housing clamped to a bearing housing via a clamp ring. The clamp ring may be configured to at least partially detach the compressor and allow the compressor to rotate and/or shift in response to a force.

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

Abstract: A publish and subscribe architecture can be utilized to manage records, which can be used to accomplish the various functional goals. At least one template having definitions for managing production and consumption of data within an unconfigured group of computing resources is maintained. Records organized by topic collected from multiple disparate previously configured producers are utilized to initiate configuration of the unconfigured group of computing resources. Records within a topic are organized by a corresponding topic sequence. A first portion of the computing resources are configured as consumers based on the at least one template. The consumers to consume records at a pace independent of record production. A second portion of the computing resources are configured as producers based on the at least one template. The producers to produce records at a pace independent of record consumption.