Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly cyclic peptide antagonists, such as compounds of formula (I).

Abstract: A formula delivery appliance can be used for treatment of the hair and scalp, such as an appliance used to color hair. The appliance may include a consumable assembly incorporating various components of the hair and scalp treatment appliance, a portion of which may be consumed and then replaced by a user. In this regard, the consumable assembly may include one or more formulation delivery packets, nozzles, manifold chambers, distribution protrusions, and the like. The hair treatment appliance may also include a rotatable coupling having a driven gear and a drive gear, where the driven gear may selectively engage the drive gear. In another aspect, the hair treatment appliance may also include a fluid container to retain a volume of formulation for delivery to the appliance.

Abstract: Described herein is an issue tracking system (ITS) comprising: one or more processors; one or more non-transitory computer-readable storage media storing sequences of instructions which, when executed by the one or more processors, cause the one or more processors to: render a user interface including a plurality of user interface elements each listing an external service from which the ITS can receive external objects and associate the received external object with one or more issues maintained by the ITS; determine, in response to a user interaction with one of the user interface elements, whether an issue maintained by the ITS is associated with an external object received from the listed external service; and render within the ITS, a user interface for an application marketplace, the application marketplace user interface including a listing of one or more integration applications that, once installed, connect the listed external service to the ITS and associate external objects received from the listed e

Abstract: A method of operating a magnetic resonance imaging (MRI) apparatus includes exciting a body coil of the MRI apparatus to emit a radio-frequency signal, determining a center frequency of a resonance curve of the body coil, and calculating a magnet target frequency based on the determined center frequency. A magnet is ramped to the magnet target frequency.

Abstract: A method of operating a magnetic resonance imaging (MRI) apparatus includes exciting a body coil of the MRI apparatus to emit a radio-frequency signal, determining a center frequency of a resonance curve of the body coil, and calculating a magnet target frequency based on the determined center frequency. A magnet is ramped to the magnet target frequency.

Abstract: A smart window/door opening-closing device that can easily be installed for use with an existing door or window or can be built-in by the door or window manufacturer, can be programmed to activate the opening or closing of the door or window either (a) remotely, (b) automatically by a pet and/or (c) automatically by a voice command, is easily disengaged when use is not desired, provides safety and security to prevent unwanted opening or closing of the door or window, and is integrated with a wireless communication network to enable smart and remote control of the window/door actuator.

Abstract: There is described herein, multimers comprising plurality of compounds covalently linked together, the compounds independently being of formula (I).

Abstract: A calibration method for calibrating a measuring element for determining an electric current flowing through a basic-field magnet of a magnetic resonance imaging system includes performing a measurement with the measuring element, and performing a frequency measurement in the magnetic field of the basic-field magnet with a frequency measuring unit. The measurement of the measuring element and the frequency measurement are corresponding to the same magnetic field of the basic-field magnet. The calibration method also includes calculating a calibration factor based on a deviation between the measurement with the measuring element and the frequency measurement, and calibrating the measuring element or the electric current in the basic-field magnet based on the calibration factor.

Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.

Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).

Abstract: A method for managing radio communications between a gateway and a plurality of sensors of a system for tracking assets is disclosed. The method includes: obtaining properties of a currently tracked asset; determining a current connection configuration for radio connections between the gateway and the plurality of sensors; identifying a preferred connection configuration for radio connections between the gateway and the plurality of sensors based on the properties of the currently tracked asset, the preferred connection configuration having at least one physical layer characteristic that is different from the current connection configuration; and in response to the identifying, causing the gateway and at least one of the plurality of sensors to switch from the current connection configuration to the preferred connection configuration for establishing a new radio connection.

Abstract: A smart window/door opening-closing device that can easily be installed for use with an existing door or window or can be built-in by the door or window manufacturer, can be programmed to activate the opening or closing of the door or window either (a) remotely, (b) automatically by a pet, (c) automatically by a voice command and/or (d) automatic in response to external sensors, is easily disengaged when use is not desired, provides safety and security to prevent unwanted opening or closing of the door or window, and is integrated with a wireless communication network to enable smart and remote control of the window/door actuator.

Abstract: The invention relates to a construct comprising a compound targeting areas in the brain involved in the regulation of body weight and an allosteric ligand to a receptor located in the blood-brain barrier (BBB). The invention also relates to compositions and uses of such construct, for example in the prevention or treatment of overweight and obesity. Preferred compounds for regulation of body weight include GLP-1 receptor agonists (GLP-1RA), and preferred receptors located in the BBB include the transferrin receptor (TfR). Exemplary fusions and conjugates of GLP-1 RA's and anti TfR-Fab's exhibit an increased binding to brain regions expressing the GLP-1 receptor as compared to fusions or conjugates with inactive control Fab's, in particular in brain areas protected by the BBB. In vivo mice studies confirm increased reduction in food intake as well as weight loss for the active construct compared to the inactive one.

Abstract: A door closer, including: an anchor assembly, including: a frame mounting plate which is fixable relative to a door frame; and an adjustor plate; and an actuator assembly for mounting within the thickness of a door leaf to move the door leaf between open and closed configurations relative to the door frame, the actuator assembly including an operating member coupled by a link to the adjustor plate and mounted for a range of movements between a fully retracted position, in which the anchor assembly is held adjacent the actuator assembly when the door leaf is in the closed configuration, and an extended position, in which the anchor assembly is in spaced relation to the actuator assembly when the door leaf is in the open configuration, the link being configured to extend from the adjustor plate along a first axis, wherein the frame mounting plate is provided with one or more slot(s), the or each slot being elongated along a second axis, the second axis being generally orthogonal to the first axis.

Abstract: A method for presenting stories includes creating clusters of documents. Each cluster corresponds to a story. A computer processor generates, for each cluster, a global ranking of social networking messages about the story. The method further includes identifying, for each cluster, a representative social networking message according to the global ranking, selecting, by the computer processor, for a user, a subset of the clusters, and presenting, to the user, the representative social networking message for each cluster in the subset of the clusters.

Abstract: A method for sensor provisioning in a wireless sensor network includes determining, at a gateway, that no neighboring gateway is present; in response to no neighboring gateway present, measuring signal strengths from a plurality of sensors; based on the measured signal strengths, identifying a sensor from the plurality of sensors to be paired with the gateway; and in response to identifying the sensor, pairing the gateway and the sensor to enable a secured connection between the gateway and the sensor.

Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.

Abstract: The present invention relates to a method of making a composite sandwich structure. The method comprises the steps of: providing a base lay-up on a surface, wherein the base lay-up comprises a first reinforcement material layer; providing a core layer on to the base lay-up, wherein the core layer comprises an open cellular structure and wherein the open cellular structure is at least partially filled with unbound particles; providing a top lay-up on top of the core layer, wherein the top lay-up comprises a second reinforcement material layer; sealing the arrangement within a hermetically sealed enclosure; introducing matrix material into the arrangement via the at least one conduit through a pressure differential; and curing the matrix material.

Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.

Abstract: A smart window/door opening-closing device that can easily be installed for use with an existing door or window or can be built-in by the door or window manufacturer, can be programmed to activate the opening or closing of the door or window either (a) remotely, (b) automatically by a pet and/or (c) automatically by a voice command, is easily disengaged when use is not desired, provides safety and security to prevent unwanted opening or closing of the door or window, and is integrated with a wireless communication network to enable smart and remote control of the window/door actuator.