Abstract: Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

Abstract: A server provides Web responses that can include content from data tables in a database. The server maintains a cache (e.g., in system memory) that can store content (including content from data tables) so as to increase the efficiency of subsequently providing the same content to satisfy client Web requests. The server monitors data tables for changes and, when a change in a particular data table occurs, invalidates cached entries that depend on a particular data table. Further, in response to a client Web request for a Web response, the server assigns a database cache dependency to at least a portion of a constructed Web response (e.g., to content retrieved from a data table) based on commands executed during construction of the Web response. The at least a portion of the constructed Web response is subsequently cached in a cache location at the server.

Abstract: Compounds of the formula wherein: Y? is O or S, W? is optionally substituted, Z? is selected from the group consisting of wherein Q? is OR7 and R7 is C1-3alkyleneC3-8heterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

Abstract: An extendable drip tray is provided to increase when needed the drip catchment area of the dish rack, to beyond the footprint or general perimeter of the dish rack. The extendable drip tray may be slidably supported by rails below the main body of the dish rack, to cover an area beyond the side of the dish rack body, thereby increasing the drip catchment area. Pivoted cup holders are provided along the outside walls of the main body of the dish rack, which can be pivoted when needed to extend an area beyond the perimeter of the body to provide supports for holding kitchen articles such as cups and glasses for drying. A wire rack is provided with pivoted support prongs for configuring the wire rack.

Abstract: Substituted urea compounds useful in the treatment of diseases and C1-3alkyleneOR3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X1 is null, —O—, —S—, —CH2—, or —N(R1)—; X2 is —O—, . -£>. -, or —N(R1)—,—. . Y xs 0 or S; or =y represents two hydrogen atoms attached to a common carbon atom, —W is selected from the group consisting of heteroaryl, aryl, heterocycloalkyl, cycloalkyl, and C1-6alkyl substituted with a heteroaryl. or aryl group; R6 is —C?C—R7 or heteroaryl; R8, R9, and R10, independently, are selected from the group consisting of halo, optionally substituted C1-6alkyl, C2-6alkenyl, C2-6alkynyl, OCP3, CF3, NO2, CN, NC, N(R3)2, OR3, CO2R3, C(O)N (R3)2, C(O)R3, N(R1)COR3, N(R1)C(O)OR3, N(R8)C(O)OR3, N(R1)C(O)C1-3alkyleneC(O)R3, N(R1)C(O)C1 -3alkyleneC(O)OR3, N(R1)C(O)C1-3alkyleneOR3, N(R1)C(O)C1-3alkyleneNHC(O)OR3, N(R1)C(O)C1-3alkyleneSO2.

Abstract: Various arrangements of carrier trays and carriers for data storage devices, such as disk drives, are disclosed. The arrangements of carrier trays and carriers are arranged to be rigid, and therefore more resistant to vibration arising from operation of the data storage device in the tray and neighboring data storage devices, and/or easier to use.

Abstract: Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.

Abstract: A module receivable within a data storage device enclosure is disclosed. The module comprises a module body and a handle arranged to lever the module into or out of its received position in a said data storage device enclosure. The handle has a plastics portion that can be gripped by a user to operate the handle, and a metal portion by which the handle is attached to the module body.

Abstract: Various arrangements of carrier trays and carriers for data storage devices, such as disk drives, are disclosed. The carrier trays and carriers have air flow holes that are carefully arranged to promote good air flow across the data storage devices. In one example, the air holes in a tray are arranged so that, when a data storage device is received on the tray, air passing over a first surface of the base from the forward end can pass through the base, over a part of a second surface and back through the base to flow across the recess typically located under the data storage device.

Abstract: Substituted urea compounds useful in the treatment of diseases and C1-3alkyleneOR3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X1 is null, —O—, —S—, —CH2—, or —N(R1)—; X2 is —O—,. -£>.-, or —N(R1)—, -..

Abstract: Systems, methods, and computer products for deriving custom cache dependencies are explained. A framework that includes an extensible cache dependency base class that can be used to derive custom cache dependency classes for invalidating cache entries on some custom condition is disclosed. In some embodiments, a Web page server includes a cache and the framework including the extensible cache dependency base. Methods are disclosed for causing a cache entry to be dependent on a customized cache dependency and for invalidating cache entries based on customized cache dependencies. For example, cache entries can depend on and be purged based on dependencies on database tables and Web services.

Abstract: In one aspect, a carrier (10) for a data storage device has a base (22) and side walls (23,24) upstanding from the base (22). A runner (25) is provided on at least one side wall (23,24) for sliding engagement with a runner (12) of a chassis (1) in which the carrier (10) is in use mounted. The carrier runner (25) is on the edge of the at least side wall (23,24) that is opposite the base (22). The width of the carrier runner (25) generally transverse to the side wall (23,24) is greater than the thickness of the at least one side wall (23,24). In another aspect, a carrier (10) for a data storage device has a base (22) and side walls (23,24) upstanding from the base (22). The material of the carrier (10) is resilient. The carrier (10) is arranged such that the carrier (10) can grip a data storage device between the side walls (23,24).

Abstract: A shelving system can include adjustable drying racks. The shelving system, which can be in the configuration of a shower caddy or shower organizer, can have a hinged clamp mechanism configured to secure the drying racks to a central support member hanging from a shower head or to another vertical support.