Abstract: One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; and a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially inserted into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber.

Abstract: Systems and methods of this disclosure make use of positive pressure to evacuate pipeline product contained within an isolated section of pipeline. In embodiments, an inert fluid is injected at a first location along the isolated section at a pressure above that of a non-isolated section of pipeline The displaced pipeline product, which may be filtered, then flows out of the isolated section at second location along the isolated section and into the non-isolated section. In other embodiments, a pressure differential between the isolated and non-isolated sections is created by lowering a pressure of the non-isolated section below that of the isolated section. The pipeline product may be a liquid, a gas, or a mixture of the two. The composition of product may be monitored as it flows through the isolated section or as it exits the section. Evacuation may be slowed or stopped based upon the composition.

Abstract: A hair styling appliance kit can include a handle section and multiple styling attachments that can be releasably attached to the handle section. The handle section can include a heating element and a blowing device so that the handle can expel hot air into a styling attachment when attached to the handle section. Each styling attachment can be releasably attached to the handle section. The styling attachments can include an oval smoothing brush, a round volume brush, and a curling wand. A user can select the desired styling attachment and position it on the mounting end of the handle section. The handle section can include a locking mechanism to selectively lock the styling attachment to the handle section during use. The amount of heat provided by the heating element is adjustable so that the temperature of the blown air is adjustable.

Abstract: A system may include a handling mast, a tubular source stack, a tubing loader, a spider device, and a connection device. The tubing loader is configured to capture a first HVT from the tubular source stack, load the first HVT into the handling mast, capture a second HVT from the tubular source stack, and load the second HVT into the handling mast. The spider device is configured to grasp the first HVT. The connection device is configured to align a proximal end of the first HVT and a distal end of the second HVT and couple the first HVT and the second HVT to form a tubing string. The handling mast is configured to insert the tubing string into the wellbore.

Abstract: A user input may be received at a user device to begin a breathing sequence. First heart rate information may be presented on a display of the user device during a first phase of the breathing sequence. A fluctuating user interface element may fluctuate on the display of the user device during a second phase of the breathing sequence. Second heart rate information may be presented on the display of the user device during a first phase of the breathing sequence.

Abstract: The present disclosure encompasses systems, methods, and compositions for diagnosing a subject for a high-grade advanced pre-malignant lesions or colorectal cancer (CRC) disease state by ascertaining the presence of certain one or more glycosylated or aglycosylated peptides in liquid biopsy samples from the subject. Specific embodiments encompass methods of measuring certain one or more glycosylated or aglycosylated peptides in liquid biopsy samples from subjects known to have or suspected of having a high-grade advanced pre-malignant lesions or CRC disease state or subjects undergoing routine health care maintenance for possible presence of a high-grade advanced pre-malignant lesions or CRC disease state. The disclosure provides systems, methods, and compositions to identify subjects at-risk for CRC or high-grade advanced pre-malignant lesions and increases subject colonoscopy compliance, in specific embodiments.

Abstract: Disclosed herein are chip packages and electronic devices that utilized an active silicon bridge having a memory controller to interface between a logic device having at least one compute die and one or more memory stacks within a singular chip package. In one example, a chip package is provided that includes a substrate, a logic device, a memory stack, and an active silicon bridge. The logic device is disposed over the substrate. The logic device includes one or more compute dies. The memory stack is disposed over the substrate adjacent the logic device. The active silicon bridge has a first portion and a second portion. The first portion is disposed between the substrate and the logic device, while the second portion is disposed between the substrate and the memory stack.

Abstract: An imaging device includes light sensitive locations that are separately sensitive to light received at a surface with respect to a portion of a sample associated with the surface, the light sensitive locations having a resolution of 5 microns or smaller. There is a device to associate the portion of the sample with the surface. The imaging device and a distance of the portion of the sample to the light sensitive locations are such that usable useful image of the portion of the sample can be acquired directly by operation of the imaging device. An imaging device can include both the light source locations and the light source locations and the light sensitive locations.

Abstract: A method of processing B-scans acquired by an OCT imaging system to generate correction data for compensating for axial displacements between B-scans caused by a variation in distance between the OCT imaging system and an imaging target, and to generate a reliability indicator indicative of a reliability of the correction data. The correction data is generated (S10) by determining, for each pair of adjacent B-scans, a respective indicator of an axial shift between respective representations of a common ocular feature in the adjacent B-scans. The reliability indicator is generated by: calculating (S20) values indicative of speeds or accelerations of the imaging target relative to the OCT imaging system when pairs of B-scans were acquired; where at least a predetermined number of calculated values exceed a threshold, setting (S40A) the reliability indictor to indicate that the correction data is unreliable, and otherwise (S40B) to indicate that the correction data is reliable.

Abstract: A method includes forming a bumpstop from a first intermetal dielectric (IMD) layer and forming a via within the first IMD, wherein the first IMD is disposed over a first polysilicon layer, and wherein the first polysilicon layer is disposed over another IMD layer that is disposed over a substrate. The method further includes depositing a second polysilicon layer over the bumpstop and further over the via to connect to the first polysilicon layer. A standoff is formed over a first portion of the second polysilicon layer, and wherein a second portion of the second polysilicon layer is exposed. The method includes depositing a bond layer over the standoff.

Abstract: The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.

Abstract: A method for analyzing a vehicle user entry and egress into a vehicle includes receiving vehicle user data and receiving vehicle data. The vehicle data includes vehicle dimensions. The method further includes determining a three-dimensional path to enter and egress the vehicle using the vehicle user data and the vehicle data, determining a user satisfaction score of the three-dimensional path to enter and egress the vehicle, comparing the user satisfaction score with a predetermined score threshold to determine whether the user satisfaction score is greater than the predetermined score threshold; and virtually updating the vehicle dimensions until the user satisfaction score is greater than the predetermined score threshold in response to determining that the user satisfaction score is not greater than the predetermined score threshold.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for classifying data points using a deferral model that determines whether to classify the data point using an output of one or more diagnostic machine learning models or to defer the data point for classification by one or more users.

Abstract: Techniques for generating modified messages via a communication platform are discussed herein. For example, one or more machine-learning models associated with a communication platform may be configured to receive, as input and from a user of the communication platform, characteristics of one or more previously modified messages shared to the communication platform. The machine-learning model may generate one or more modified messages containing at least one characteristic of the previously modified messages and allowing the user to share the modified message to the communication platform.

Abstract: A surgical tool (1) comprising: a plurality of arms (2), each of the plurality of arms comprises an aperture; an elongate pin extending through the aperture of each of the plurality of arms, said elongate pin (8) comprising an end stop (10) at a first end of the elongate pin, said stop (10) being adjacent to the aperture of a first arm (3) of the plurality of arms (2), and an end portion at a second end of the elongate pin, said end portion extending beyond a second arm (4) of the plurality of arms; a bearing plate mounted onto said end portion of the pin directly adjacent to the aperture of the second arm (4), wherein the end portion comprises a deformed region, deformed such that the pin (8) forms an interference fit with the bearing plate. Also provided is a method (400) of manufacturing said surgical tool.

Abstract: A wind-powered energy generation system has a venturi with an air inlet adapted to receive a wind stream, an air outlet, a restriction between the air inlet and the air outlet, and a fluid port in fluid communication within the restriction. A fluid line is connected to the fluid port such that a low-pressure force generated within the restriction applies a vacuum force to the fluid line. An energy conversion device converts the vacuum force into motive energy.

Abstract: An elongate composite beam 26 for securing or anchoring a solar array 10. The beam 26 comprising a hollow outer shell 28 formed from a C-section beam that has a closed end wall 30, a pair of side walls 32, and end wall sections 34, 36 that extend inwardly towards each other from ends of the side walls 32. Opposed ends of the end wall sections 34, 36 are spaced apart to define an elongate gap G. The closed end wall 30, the side walls 32 and the end wall sections 34, 36 define a shell interior. At least one of the end wall sections 34, 36 comprises an inwardly extending lip 38, 40 that extends in a direction towards the closed end wall 30 inwardly into the shell interior. The shell interior is substantially filled with a settable material 42 which engages about the inwardly extending lip 38, 40.

Abstract: A device arranged to be in fluid communication with a patient interface arranged to be in communication with an airway of a patient during respiratory therapy, the device comprising: an inlet for receiving a breathable gas from a respiratory apparatus; an outlet for conveying the breathable gas to the patient interface; a body portion extending between the inlet and the outlet, wherein the body portion includes a trigger port, and one or more sensors, wherein output of the one or more sensors is used to determine a status of the trigger port.

Abstract: Rotary cutting tools are disclosed comprising shanks and replaceable cutting inserts are provided. A head of the cutting insert includes insert centering surfaces that contact the pocket centering walls of the shank, and insert drive surfaces that contact the torque transmitting pocket drive walls of the shank. The configurations and sizes of the shank and cutting insert features are controlled to provide improved torque transmission, rigidity and stability during operation of the rotary cutting tools.

Abstract: An electric propulsion system for a vertical take-off and landing (VTOL) aircraft having a heat exchanger to cool fluids used in an electrical engine, the electric propulsion system comprising at least one electrical engine mechanically connected directly or indirectly to a fuselage of the VTOL aircraft and electrically connected to an electrical power source. The electrical engine may comprise an electrical motor having a stator and a rotor; a gearbox assembly comprising a sun gear; at least one planetary gear; a ring gear; and a planetary carrier. The electric engine may include an inverter assembly comprising a thermal plate and an inverter assembly housing; an end bell assembly that is connected to the thermal plate of the inverter assembly; and a heat exchanger comprising an array of cooling fins and tubes.