Patents by Inventor Alex Van Eck Conradie

Alex Van Eck Conradie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOCATALYTIC PROCESSES AND MATERIALS FOR ENHANCED CARBON UTILIZATION
    Publication number: 20170240936
    Abstract: The present disclosure describes biocatalytic processes for producing a product, comprising providing an aqueous stream (AS) comprising at least one fermentable substrate and a gaseous stream (GS) comprising at least one of CO2/H2, H2, methane, and/or CO to a fermentation zone, wherein the GS and AS stream are optionally contacted and/or mixed; the fermentation zone comprising at least one organism capable of metabolizing an AS substrate and a GS substrate, wherein the fermentation operates at conditions to mixotrophically metabolize at least one gaseous substrate in the GS and at least one substrate in the AS, producing the product.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 24, 2017
    Applicant: INVISTA North America S.a.r.l.
    Inventors: Gary SMITH, Alex Van Eck CONRADIE, Gregory S. KIRBY, Paul S. PEARLMAN
  • METHODS OF PRODUCING 7-CARBON CHEMICALS VIA AROMATIC COMPOUNDS
    Publication number: 20170240933
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
    Type: Application
    Filed: February 24, 2017
    Publication date: August 24, 2017
    Inventors: Paul S. Pearlman, Alex Van Eck Conradie, Changlin Chen, Adriana Leonora Botes
  • Methods, reagents and cells for biosynthesizing compounds
    Patent number: 9738914
    Abstract: This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: August 22, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Alex Van Eck Conradie, Adriana Leonora Botes, Ramdane Haddouche
  • Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation
    Patent number: 9738911
    Abstract: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: August 22, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Alex Van Eck Conradie, Adriana Leonora Botes, Changlin Chen, Paul S. Pearlman
  • Methods of Producing 6-Carbon Chemicals From Long Chain Fatty Acids Via Oxidative Cleavage (as amended)
    Publication number: 20170233777
    Abstract: This document describes biochemical pathways for producing adipyl-[acp] and either hexanoic acid or acetic acid from a long chain acyl-[acp] such as dodecanoyl-[acp] or octanoyl-[acp] using a polypeptide having pimeloyl-[acp] synthase activity and biochemical pathways for converting adipyl-[acp] and/or hexanoic acid to one of more of adipic acid, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine, caprolactam, and 1,6-hexanediol.
    Type: Application
    Filed: May 13, 2015
    Publication date: August 17, 2017
    Applicant: INVISTA TECHNOLOGIES S.A.R.L.
    Inventors: Adriana Leonora BOTES, Alex Van Eck CONRADIE
  • METHODS FOR PRODUCING 6-CARBON CHEMICALS VIA METHYL-ESTER SHIELDED CARBON CHAIN ELONGATION
    Publication number: 20170204438
    Abstract: This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
    Type: Application
    Filed: January 13, 2017
    Publication date: July 20, 2017
    Inventors: Adriana Leonora BOTES, Alex Van Eck Conradie
  • METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS
    Publication number: 20170204420
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
    Type: Application
    Filed: January 13, 2017
    Publication date: July 20, 2017
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CARBON CHAIN ELONGATION ASSOCIATED WITH CYCLOHEXANE CARBOXYLATE SYNTHESIS
    Publication number: 20170191096
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
    Type: Application
    Filed: March 15, 2017
    Publication date: July 6, 2017
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • METHODS AND MATERIALS FOR PRODUCING 5 AND 7-CARBON MONOMERS
    Publication number: 20170159086
    Abstract: This document describes biochemical pathways for biosynthesizing a 3-oxo-7-hydroxyheptanoyl-CoA intermediate using a ?-ketothiolase, and enzymatically converting 3-oxo-7-hydroxyheptanoyl-CoA to 7-hydroxyheptanoic acid. -7-hydroxyheptanoic acid can be further enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7-heptanediol.
    Type: Application
    Filed: November 10, 2016
    Publication date: June 8, 2017
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • PROCESS FOR PRODUCING GLUTARATE AND GLUTARIC ACID METHYL ESTER
    Publication number: 20170152531
    Abstract: This document describes biochemical pathways for producing 2,4-pentadienoyl-CoA by forming one or two terminal functional groups, comprised of carboxyl or hydroxyl group, in a C5 backbone substrate such as glutaryl-CoA, glutaryl-[acp] or glutarate methyl ester. 2,4-pentadienoyl-CoA can be enzymatically converted to 1,3-butadiene.
    Type: Application
    Filed: June 16, 2015
    Publication date: June 1, 2017
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • METHODS, HOSTS, AND REAGENTS RELATED THERETO FOR PRODUCTION OF UNSATURATED PENTAHYDROCARBONS, DERIVATIVES AND INTERMEDIATES THEREOF
    Publication number: 20170145441
    Abstract: This application describes methods, including non-naturally occurring methods, for biosynthesizing unsaturated pentahydrocarbons, such as isoprene and intermediates thereof, via the mevalonate pathway, as well as non-naturally occurring hosts for producing isoprene.
    Type: Application
    Filed: August 16, 2016
    Publication date: May 25, 2017
    Inventor: Alex Van Eck CONRADIE
  • Bioconversion process for producing nylon-7, nylon-7,7 and polyesters
    Patent number: 9650653
    Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: May 16, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
  • Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
    Patent number: 9637764
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: May 2, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • Methods of producing 7-carbon chemicals via aromatic compounds
    Patent number: 9617572
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: April 11, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme B synthesis
    Patent number: 9580731
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: February 28, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation
    Patent number: 9580733
    Abstract: This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: February 28, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • METHODS, CELLS AND REAGENTS FOR PRODUCTION OF ISOPRENE, DERIVATIVES AND INTERMEDIATES THEREOF
    Publication number: 20170051314
    Abstract: This application describes methods, including non-naturally occurring methods, for biosynthesizing 3-hydroxy-3-methylglutaryl-coA and intermediates thereof, as well as non-naturally occurring hosts for producing 3-hydroxy-3-methylglutaryl-coA. This application also describes methods, including non-naturally occurring methods, for biosynthesizing isoprene and intermediates thereof, as well as non-naturally occurring hosts for producing isoprene.
    Type: Application
    Filed: August 16, 2016
    Publication date: February 23, 2017
    Inventor: Alex Van Eck CONRADIE
  • METHODS AND HOST CELLS FOR ENHANCING PRODUCTION OF 1, 3-BUTANEDIOL
    Publication number: 20170009263
    Abstract: This application describes non-naturally occurring host cells for enhanced 1,3-butanediol (1,3-BDO) production, methods for producing 1,3-BDO using such non-naturally occurring host cells, and 1,3-BDO products produced by such non-naturally occurring host cells and methods.
    Type: Application
    Filed: July 7, 2016
    Publication date: January 12, 2017
    Inventors: Alex Van Eck CONRADIE, Mariusz Stanislaw KAMIONKA
  • METHODS FOR BIOSYNTHESIZING 1,3 BUTADIENE
    Publication number: 20160355843
    Abstract: This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
    Type: Application
    Filed: July 15, 2016
    Publication date: December 8, 2016
    Applicant: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana Leonora Botes, Alex Van Eck Conradie
  • METHODS FOR BIOSYNTHESIZING 1,3 BUTADIENE
    Publication number: 20160355844
    Abstract: This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
    Type: Application
    Filed: July 19, 2016
    Publication date: December 8, 2016
    Applicant: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana Leonora Botes, Alex Van Eck Conradie