Patents by Inventor Alex Van Eck Conradie

Alex Van Eck Conradie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS
    Publication number: 20150361467
    Abstract: This document describes biochemical pathways for producing 5-hydroxypentanoate methyl ester and pentanoic acid pentyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 5-hydroxypentanoate methyl esters and pentanoic acid pentyl esters can be enzymatically converted to glutaric acid, 5-aminopentanoate, 5-hydroxypentanoate, cadaverine, or 1,5-pentanediol.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 17, 2015
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Ramdane Haddouche
  • METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS
    Publication number: 20150361465
    Abstract: This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 17, 2015
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Ramdane Haddouche
  • BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS
    Publication number: 20150337275
    Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
    Type: Application
    Filed: December 21, 2012
    Publication date: November 26, 2015
    Applicant: INVISTA TECHNOLOGIES S.a.r.l.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
  • METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE
    Publication number: 20150307854
    Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
    Type: Application
    Filed: March 23, 2015
    Publication date: October 29, 2015
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE
    Publication number: 20150267211
    Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6; backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
    Type: Application
    Filed: March 23, 2015
    Publication date: September 24, 2015
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
    Patent number: 9102960
    Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogs enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: August 11, 2015
    Assignee: INVISTA North America S.á.r.l.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
    Patent number: 9102958
    Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 11, 2015
    Assignee: INVISTA North America S.á.r.l.
    Inventors: Adriana L. Botes, Alex Van Eck Conradie
  • METHODS AND MATERIALS FOR PRODUCING FIVE CARBON BUILDING BLOCKS FROM PROLINE
    Publication number: 20150111262
    Abstract: This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as D-proline.
    Type: Application
    Filed: August 27, 2014
    Publication date: April 23, 2015
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • METHODS FOR BIOSYNTHESIZING 1,3 BUTADIENE
    Publication number: 20150079654
    Abstract: This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as, inter alia, a decarboxylating thioesterase, cytochrome P450, or dehydratases for the final enzymatic step.
    Type: Application
    Filed: July 17, 2014
    Publication date: March 19, 2015
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • METHODS FOR BIOSYNTHESIS OF ISOPRENE
    Publication number: 20150037860
    Abstract: This document describes biochemical pathways for producing isoprene by forming two vinyl groups in a central precursor produced from isobutyryl-CoA, 3-methyl-2-oxopentanoate, or 4-methyl-2-oxopentanoate as well as recombinant hosts for producing isoprene.
    Type: Application
    Filed: August 5, 2014
    Publication date: February 5, 2015
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • Methods of Producing 7-Carbon Chemicals via CoA-Dependent Carbon Chain Elongation Associated with Carbon Storage
    Publication number: 20140248673
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-hydroxyheptanoic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the CoA-dependent elongation enzymes or analog enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
    Type: Application
    Filed: December 13, 2013
    Publication date: September 4, 2014
    Applicant: INVISTA North America S.á r.I.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • Bioconversion Process for Producing Nylon-7, Nylon-7, 7 and Polyesters
    Publication number: 20140242655
    Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
    Type: Application
    Filed: June 29, 2012
    Publication date: August 28, 2014
    Applicant: INVISTA TECHNOLOGIES S.A R.L.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana Leonora Botes, Alex Van Eck Conradie, Benjamin D. Herzog
  • Methods Of Producing 6-Carbon Chemicals Via Methyl-Ester Shielded Carbon Chain Elongation
    Publication number: 20140199737
    Abstract: This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 17, 2014
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • Methods Of Producing 7-Carbon Chemicals Via Aromatic Compounds
    Publication number: 20140193861
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicant: INVISTA North America S.á.r.l.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • Methods Of Producing 7-Carbon Chemicals Via Pyruvate And Succinate Semialdehyde Aldol Condensation
    Publication number: 20140193864
    Abstract: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicant: INVISTA North America S.á r.l.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • Methods Of Producing 7-Carbon Chemicals From Long Chain Fatty Acids Via Oxidative Cleavage
    Publication number: 20140193865
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicant: INVISTA North America S.á r.I.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • Methods Of Producing 7-Carbon Chemicals Via C1 Carbon Chain Elongation Associated With Coenzyme B Synthesis
    Publication number: 20140193863
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicant: INVISTA North America S.á r.I.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • Methods Of Producing 7-Carbon Chemicals Via Carbon Chain Elongation Associated With Cyclohexane Carboxylate Synthesis
    Publication number: 20140193862
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicant: INVISTA North America S.á r.I.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE
    Publication number: 20140186902
    Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
    Type: Application
    Filed: December 13, 2013
    Publication date: July 3, 2014
    Applicant: INVISTA North America S. a r.l.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • Methods Of Producing 7-Carbon Chemicals Via Methyl-Ester Shielded Carbon Chain Elongation
    Publication number: 20140186904
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 3, 2014
    Applicant: INVISTA North America S.á r.l.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman