Abstract: A compound, having the formula A-1: Wherein R1 and R2 are defined herein. Methods of using the compound and compositions containing the compound are provided.

Abstract: The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent.

Abstract: System and method for aggressively trading a spread trading strategy in an electronic environment are provided herein. According to the example embodiments, a trader may configure the automated trading tool to trade as aggressively as possible by leaning on a price without an associated quantity. This allows a trader to possibly obtain a more profitable price as well as get filled faster. Traders submit an order for a spread and the automated trading tool calculates the quote order price based on a defined level of aggressiveness, the leaned on price, and the desired spread price. Based on the level of defined aggressiveness and the gap in the market, the automated trading tool may lean on a mildly, moderately, or extremely aggressive price.

Abstract: The present invention extends to methods, systems, and computer program products for providing a conversational user interface (CUI) which interacts audibly with a customer of a retail location. The CUI can ask questions to or respond to questions from the customer, provide audible information regarding products or services available within the retail location, or otherwise assist the customer as the customer shops at the retail location. The CUI can be provided on virtually any device capable of outputting audio content including portable devices such as mobile phones, smart phones, tablets, gaming devices, and stationary devices such as televisions, monitors, or other display devices.

Abstract: The present invention extends to methods, systems, and computer program products for identifying the location of a customer within a retail environment using a smart device carried by the customer. One or more transponders can be located in the retail environment and can communicate with the smart device to determine the location of the smart device. Once the location of the smart device is determined, customized content can be displayed to the customer carrying the smart device. The customized content can be related to a product that is displayed in proximity of the location of the smart device.

Abstract: The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions, into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g.

Abstract: Bone screws and bone plates are provided that offer the surgeon the ability to either assemble the screws to the plate, or the plate to the screws, depending on the surgeon's preference and the patient's circumstances. The bone screws and bone plates of the present invention include a combination of geometric configurations that allow the screws and plates to fit together from different assembly directions. Additionally, the bone screws and bone plates can include material resilience features to allow expansion/contraction during assembly to allow bidirectional attachment to one another.

Abstract: A system and methods are provided for using order descriptor identifiers in relation to orders being used in trading strategies. According to one example method, when a hedge order is submitted upon detecting a fill of another order, the hedge order includes one or more order descriptor identifiers conveying a purpose of the hedge order to a user. The order descriptor identifiers can be used to search for desired orders and perform more effective order management and post trade analysis.

Abstract: A measurement system and method of forecasting time-dependent corrections into a power output of photovoltaic power generators based on a determination of time-dependent shading of photovoltaic cells. Identification of cloud positioning in the sky is based on recordation of images of a scene within a field-of-view FOV that optionally subtends the Sun, base on which images a velocity vector associated with cloud movement is computed to form output associated with time when clouds will shade power generators in question. A method for producing a weather forecast based on such corrections.

Abstract: Methods and apparatus for processing data. The apparatus includes a plurality of entry systems for receiving the data from a respective plurality of contributors which each formulate the data based on respectively different: a) input data, and b) rules for governing how the input data is used to formulate the data. The apparatus also includes a tracking system having a data normalizer configured to normalize the formulated data received from each of the plurality of contributors into a common format. The tracking system performs at least one comparison of the normalized data from the entry systems and signals results of the comparison.

Abstract: Systems and methods of this disclosure can operate to provide audio level normalization in multimedia streams. In some implementations, audio level normalization can include partially decoding audio frames included in a multimedia stream, calculating an average energy level of the partially decoded frames, comparing the average energy level of the partially decoded frames to a nominal energy level, modifying a dialnorm setting associated with the multimedia stream, and reencoding the partially decoded audio frames for inclusion as a modified audio stream corresponding to the video stream.

Abstract: A method and apparatus for including in a processor instructions for performing multiply-add operations on packed data. In one embodiment, a processor is coupled to a memory. The memory has stored therein a first packed data and a second packed data. The processor performs operations on data elements in said first packed data and said second packed data to generate a third packed data in response to receiving an instruction. At least two of the data elements in this third packed data storing the result of performing multiply-add operations on data elements in the first and second packed data.

Abstract: A kitchen appliance includes a housing that defines a cavity. The housing has a housing rim defining an opening to the cavity. A heating or cooling element is disposed within the housing to heat or cool the cavity. A container has a generally hollow interior and a container rim. A lid is sized and shaped to at least partially cover the opening of the container when placed on the container. The lid has an exterior surface and an opposing interior surface. At least one latching mechanism or handle is operable to seal the contents of the appliance within the appliance.

Abstract: System and methods for reducing the risks involved in trading multiple spread trading strategies in an electronic trading environment are provided. Specifically, reducing the risks involved in trading multiple spreads that share a leg by, among other things, quoting a single order in the shared leg instead of quoting orders for each of the corresponding spread legs. Based on the computed quote price for the single order, associating the single order with the leaned on price that results in the price closest to the inside market in the shared leg. The single quote order is based on the market conditions in the spread legs and the desired spread price. Once the single order fills, a hedge order is sent to the leg that obtains the most advantageous price for the spread based on the other spread options.

Abstract: A system and associated methods are provided for intelligent placement and movement of orders in an electronic trading environment. According to one example method, in addition to submitting a leg order at a calculated price level, additional orders, queue holder orders, are submitted for the leg order at prices either below or above the calculated price level. Based on this configuration, if the conditions change such that it is necessary to re-price the leg order, there will be already an order resting in the exchange order book at the re-calculated price that can be used in the strategy. Upon re-pricing the leg order, one or more additional queue holder orders will be placed in the market. Other tools are provided as well.

Abstract: Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA ligases, for example to identify the human DNA ligase involved in different DNA repair pathways. Screening methods for compounds that inhibit human DNA ligases.

Abstract: A system and associated methods are provided for use of fractional pay-up ticks in relation to offset orders being sent for a trading strategy that involves trading a first tradeable object and at least a second tradeable object. According to one example method, when an indication is received that a quantity at a first price for the first tradeable object is filled, a plurality of offset orders for the second tradeable object is sent to an electronic order book of the second tradeable object. The plurality of offset orders is placed at a plurality of price levels determined based on at least one fractional pay-up tick value, the first price, and the desired spread price. A quantity for each order is determined based on a quantity divider rule that is applied to an offset quantity to offset the fill.

Abstract: The annotation of a returned reference from an executable component to signify that there are no external references to the particular object graph referenced by the returned reference. If either 1) there are no input arguments to the executable component or 2) each input argument is either immutable or represents an object graph that has no external mutable references pointing into the object graph, and no internal mutable references that reference external objects, the particular attribute is assigned to the returned reference. Accordingly, if the returned reference is writable (as determined by evaluating the declaration code or the call code for the executable component), the returned reference is free to have whatever access permissions assigned to it, and may also be assigned to an isolated memory location, though such assignments will cause the returned reference to lose the particular attribute.

Abstract: There is disclosed a conveyor drive roller of the type which may be used for example for supporting and driving a conveyor medium. The conveyor drive roller has a hollow drum which defines a cylindrically shaped rotatable supporting surface, and an internal surface. The hollow drum is rotatably connected to a first and a second support structure. An internal gear assembly is disposed inside of the hollow drum and operably connected to the internal surface of the hollow drum. The second support structure is adapted to permit a rotor of a motor located outside of the hollow drum to releasably couple to the internal gear assembly through the second support structure, so that when the rotor is coupled to the internal gear assembly, through the second support structure, rotation of the rotor is transmitted by the internal gear assembly to the hollow drum to cause rotation of the hollow drum about the first and second support structures.

Abstract: There is disclosed a conveyor drive roller of the type which may be used for example for supporting and driving a conveyor medium. The conveyor drive roller has a hollow drum which defines a cylindrically shaped rotatable supporting surface, and an internal surface. The hollow drum is rotatably connected to a first and a second support structure. An internal gear assembly is disposed inside of the hollow drum and operably connected to the internal surface of the hollow drum. The second support structure is adapted to permit a rotor of a motor located outside of the hollow drum to releasably couple to the internal gear assembly through the second support structure, so that when the rotor is coupled to the internal gear assembly, through the second support structure, rotation of the rotor is transmitted by the internal gear assembly to the hollow drum to cause rotation of the hollow drum about the first and second support structures.