Abstract: An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.

Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described and the compositions having enhanced active component permeation properties are described as being administered with specific residence times.

Abstract: The present disclosure relates generally to methods of treating, preventing, or reducing nausea, vomiting, or a combination thereof, hyperemesis gravidarum (HG), nausea and vomiting of pregnancy (NVP), or sequelae thereof in a human subject in need thereof, the method comprising administering to the human subject a therapeutically effective amount of an antibody that specifically binds to human glial cell line-derived neurotrophic factor family receptor alpha-like (GFRAL).

Abstract: A sole for an article of footwear includes an outsole that has longitudinal ribs and a midsole that is disposed above the outsole and that defines notches. The longitudinal ribs arc disposed in the notches.

Abstract: An example method of enforcing granular access policy for embedded artifacts comprises: detecting an association of an embedded artifact with a resource container; associating the embedded artifact with at least a subset of an access control policy associated with the resource container; and responsive to receiving an access request to access the embedded artifact, applying the access control policy associated with the resource container for determining whether the access request is grantable.

Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.

Abstract: The present invention provides a computer-implemented method for estimating the cancer cell fraction (CCF) of at least one tumour-specific mutation in a subject. Also provided are related methods for monitoring the clonal dynamics of a tumour, monitoring a treatment of the tumour and methods for treating a subject having a cancer, as well as systems for implementing the methods of the invention.

Abstract: A sole for an article of footwear includes an outsole that has longitudinal ribs and a midsole that is disposed above the outsole and that defines notches. The longitudinal ribs are disposed in the notches.

Abstract: The present disclosure relates to systems and methods for tracking content across multiple content outlets. Content items, characterized by first metadata, and content slots, characterized by second metadata, can be received. Third metadata for digital content slots can be generated. Fourth metadata can be received. A recommended content item package can be provided based on a comparison between a combination of the first metadata, the second metadata, and the third metadata and the fourth metadata. The recommended content item package can include a content file and a metadata file. A performance and a measurement of the recommended content item package can be determined by executing the metadata file to track the content file across one or more of the content slots and the potential digital content slots. The performance and the measurement can be provided.

Abstract: Sleep conditions such as sleep apnea can be assessed using a multi-night assessments. A respiration signal (e.g., acquired from a sensor strip) can be processed via a computing device. The respiration signal can be segmented and the segments can be classified to identify one or more apnea/hypopnea events. In some examples, some of the segments can be normalized such that each segment input for classification can be of the same size. The identified one or more apnea/hypopnea events can be used to estimate a nightly parameter indicative of a severity of (or presence of) sleep apnea. The nightly parameters from a multi-night period can be used to estimate a multi-night parameter indicative of the severity of (or presence of) sleep apnea. In some examples, quality checks can be performed to filter out some data (e.g., to exclude data from entire nights or exclude a portion of data from individual nights).

Abstract: An example method of enforcing granular access policy for embedded artifacts comprises: detecting an association of an embedded artifact with a resource container; associating the embedded artifact with at least a subset of an access control policy associated with the resource container; and responsive to receiving an access request to access the embedded artifact, applying the access control policy associated with the resource container for determining whether the access request is grantable.

Abstract: The present disclosure relates to systems and methods for tracking content across multiple content outlets. Content items, characterized by first metadata, and content slots, characterized by second metadata, can be received. Third metadata for digital content slots can be generated. Fourth metadata can be received. A recommended content item package can be provided based on a comparison between a combination of the first metadata, the second metadata, and the third metadata and the fourth metadata. The recommended content item package can include a content file and a metadata file. A performance and a measurement of the recommended content item package can be determined by executing the metadata file to track the content file across one or more of the content slots and the potential digital content slots. The performance and the measurement can be provided.

Abstract: Pharmaceutical compositions having enhanced active component permeation properties are described.

Abstract: The present disclosure relates to systems and methods for tracking content across multiple content outlets. Content items, characterized by first metadata, and content slots, characterized by second metadata, can be received. Third metadata for digital content slots can be generated. Fourth metadata can be received. A recommended content item package can be provided based on a comparison between a combination of the first metadata, the second metadata, and the third metadata and the fourth metadata. The recommended content item package can include a content file and a metadata file. A performance and a measurement of the recommended content item package can be determined by executing the metadata file to track the content file across one or more of the content slots and the potential digital content slots. The performance and the measurement can be provided.

Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described, the prodrugs having a half-life of less than one minute, and the compositions having enhanced active component permeation properties are described.

Abstract: Sleep conditions such as moderate-to-severe sleep apnea can be assessed using a multi-night assessments. A respiration signal (e.g., acquired from a sensor strip) can be processed via a computing device. The respiration signal can be segmented and the segments can be classified to identify one or more apnea/hypopnea events. In some examples, some of the segments can be normalized such that each segment input for classification can be of the same size. The identified one or more apnea/hypopnea events can be used to estimate a nightly parameter indicative of a severity of (or presence of) sleep apnea. The nightly parameters from a multi-night period can be used to estimate a multi-night parameter indicative of the severity of (or presence of) sleep apnea. In some examples, quality checks can be performed to filter out some data (e.g., to exclude data from entire nights or exclude a portion of data from individual nights).

Abstract: The present disclosure relates to systems and methods for enhancing data from disjunctive sources using a weighted interaction graph. First data about first entities can be received from a first data source. Second data about second entities at least partially different than the first entities can be received from a second data source. Relationships between each entity of the first entities and second entities can be determined, and a set of classes can be inferred from the first data and from the second data. A weighted interaction graph can be generated. The weighted interaction graph can indicate a likelihood of each entity interacting with a corresponding class. An extended set of data can be generated using the weighted interaction graph. The extended set of data can be output to facilitate communication with third entities that include the first entities and the second entities.

Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.

Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described and the compositions having enhanced active component permeation properties are described as being administered with specific residence times.

Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.