Abstract: Soluble drug delivery films can exhibit an enhanced stability.

Abstract: The present disclosure relates generally to methods of treating (i) a tumor (e.g., a solid tumor, an advanced solid tumor, a cancer), (ii) tumor-related weight loss, or (iii) tumor-related cachexia in a human patient, the method comprising administering to the human patient an anti-GDNF family receptor alpha-like (GFRAL) antibody, wherein the antibody inhibits GFRAL binding to Ret proto-oncogene (RET). The present disclosure also relates generally to methods of treating pancreatic cancer (e.g., an advanced pancreatic cancer, a metastatic pancreatic cancer, a pancreatic adenocarcinoma, a metastatic pancreatic adenocarcinoma, an MSI-H pancreatic cancer, a pancreatic ductal adenocarcinoma, a metastatic pancreatic ductal adenocarcinoma) in a human patient, comprising administering to the human patient (i) an anti-GFRAL antibody, wherein the antibody inhibits GFRAL binding to RET; (ii) paclitaxel; and (iii) gemcitabine.

Abstract: An example method of enforcing granular access policy for embedded artifacts comprises: detecting an association of an embedded artifact with a resource container; associating the embedded artifact with at least a subset of an access control policy associated with the resource container; and responsive to receiving an access request to access the embedded artifact, applying the access control policy associated with the resource container for determining whether the access request is grantable.

Abstract: Systems, methods, and non-transitory computer readable media may provide a view of geospatial information. A user's selection of a location may be obtained. Characteristic information describing characteristics of the location may be obtained. Activities information describing activities of the location may be obtained. An interface (e.g., user interface, API) enabling presentation of a geospatial view of the activities of the location with respect to the characteristics of the location may be provided.

Abstract: A sole for an article of footwear includes an outsole that has longitudinal ribs and a midsole that is disposed above the outsole and that defines notches. The longitudinal ribs are disposed in the notches.

Abstract: The present invention relates to a seed coating composition comprising at least: (a) a polyvinyl acetate binder, (b) activated carbon powder, and (c) at least two minerals from the group of calcium carbonate, micro-mica, vermiculite or a silicon-comprising clay. The present invention is furthermore related to the method for producing seed pellets, comprising blending the components (a) to (c), water and seeds to be coated in a pelletizer such that the seeds are coated, and, and drying the coated seeds to obtain seed pellets, and, optionally, sieving the thus obtained seed pellets.

Abstract: An example method of enforcing granular access policy for embedded artifacts comprises: detecting an association of an embedded artifact with a resource container; associating the embedded artifact with at least a subset of an access control policy associated with the resource container; and responsive to receiving an access request to access the embedded artifact, applying the access control policy associated with the resource container for determining whether the access request is grantable.

Abstract: A toothpaste dispensing pen style toothbrush including a toothbrush head assembly, a housing assembly, and an electrical assembly is disclosed. These assemblies in conjunction with one another provide a simple solution to brushing your teeth. The housing assembly includes toothpaste stored therein. A screw rod is longitudinally mounted within the housing assembly. At a bottom portion of the screw rod is a screw cup. The screw cup travels the length of the screw rod when a button is pressed to actuate a battery powered motor that spins the screw rod. The screw cup then pushes the toothpaste out of the housing and into the toothbrush head assembly along a channel. The channel ends at an outlet on a toothbrush head. Thereby dispensing toothpaste onto toothbrush bristles. A user can place a cap over the toothbrush head assembly that resembles a pen cap.

Abstract: An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.

Abstract: Self-supporting film unit dosage forms for oral transmucosal delivery are disclosed herein containing an active. These film dosage forms for oral transmucosal delivery have a substantially equivalent pharmacokinetic profile to dosage forms administered by another route or in another dosage form (e.g., tablet, patch) and yet have a different amount of active contained therein.

Abstract: A bioreactor system includes a vessel having a bottom floor, a flexible bioprocessing bag disposed within the vessel, and a flexible bladder positioned intermediate the bottom floor of the vessel and the bioprocessing bag. The flexible bladder is selectively inflatable to vary at least one of a geometry or configuration of the bioprocessing bag to provide for improved drainability or an increased turndown ratio for the bioreactor system.

Abstract: Systems and methods of delivering a drug product by inhalation can include a prodrug composition.

Abstract: A bioreactor vessel includes a bottom, a peripheral sidewall, the bottom and the peripheral sidewall defining an interior space for receiving a flexible bioprocessing bag, a recess in the bottom for receiving a base plate of the flexible bioprocessing bag, and a locking mechanism configured to retain the base plate in the recess.

Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described, the prodrugs having a half-life of less than one minute, and the compositions having enhanced active component permeation properties are described.

Abstract: Pharmaceutical compositions having enhanced active component permeation properties are described.

Abstract: Provided herein are methods of using 7?-hydroxy-4-cholesten-3-one (C4) in predicting the clinical sensitivity to treatment of bile acid-related and associated disorders with treatment peptides, such as variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics).

Abstract: A surgical tool having a compact design is disclosed. The tool has a first set of prongs disposed along a first axis, a second set of prongs disposed along a second axis different from the first, and an asymmetric gear set. The gear set includes a rotatable first drive gear disposed on one of the first set of prongs and a rotatable first actuator gear disposed on one of the second set of prongs. The first drive gear is configured to drive the first actuator gear, forming a first gear pair. The gear set also includes a rotatable second drive gear disposed on one of the first set of prongs and a rotatable second actuator gear disposed on one of the second set of prongs. The second drive gear is configured to drive the second actuator gear, forming a second gear pair. The first gear pair and the second gear pair have different diameters.

Abstract: The present disclosure provides dye compounds for use in dyeing textiles.

Abstract: The present disclosure provides dye compounds for use in dyeing textiles.

Abstract: Systems and methods are provided for collaborating with different object models. Data corresponding to one or more source objects is received. The source objects is stored in a first object model, and each of the source objects is associated with information describing an entity. Matches between the respective information associated with the one or more source objects and respective information associated with one or more target objects are determined based on a query. The target objects are stored in a second object model. The one or more source objects are ranked based at least in part on the matches. A list of the ranked source objects are provided through an interface, the interface indicating a number of matching target objects for each of the source objects.