Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Abstract: The present disclosure describes a high-throughput methodology for rapid and highly personalized screenings to identify efficacious anti-tumor immunotherapy regiments. In one embodiment, therapeutic agents or a combination thereof are screened by co-culturing tumor shaped organoid extrudates with a population of immune cells taken from the same patient. Reduced tumor cell functions or increased immune cell functions in the presence of the therapeutic agents or combination thereof would identify the therapeutic agents or combination thereof for treating the tumor in the patient.

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Abstract: A computer system is configured to receiving a data set from a data provider and automatically save the data set in a quarantine database where copying, moving, and sharing of the data set are restricted until the data set is released by a data provider. The data set is parsed to find and mark portions with potentially sensitive information. At least those parts are reviewed by a data governor, who can confirm, add, edit, or remove markers. Those parts can be visually indicated to the data governor, along with a preview of, metadata about, and analysis of the data set. After reviewing at least the automatically marked portions, the data governor can release the data set to a non-quarantine database where another user can use the data set. The user is restricted from accessing the quarantine database.

Abstract: The various implementations described herein include methods and devices for media discovery. In one aspect, a method includes obtaining a pre-trained recommender model that has been trained using contrastive learning with feature-level augmentation and instance-level augmentation. The method further includes generating, via the model, a user embedding based on features of the user and generating, via the model, a respective episode embedding for each episode of a plurality of episodes, each respective episode embedding based on features of the corresponding episode. The method also includes generating, via the model, a respective similarity score (corresponding to a latent similarity between the user embedding and each respective episode embedding) for each episode, the respective similarity score, and ranking the episodes in accordance with the respective similarity scores. The method further includes recommending the highest ranked episode to the user.

Abstract: Methods and apparatuses for providing a permissions-aware search and knowledge management system that incorporates user suggested results, document verification, and intelligent user activity tracking across group hierarchies to improve the quality and relevance of search results are described. The permissions-aware search and knowledge management system may enable content stored across a variety of local and cloud-based data stores to be indexed, searched, and displayed to authorized users. The identification and ranking of relevant documents corresponding with a user's search query may take into account user suggested results from the user and others assigned to the same group as the user, whether the underlying content of a search result was verified by a content owner as being up-to-date, the amount of time that has passed since the underlying content was verified by the content owner, and the recent activity of the user and related group members.

Abstract: Techniques described herein are directed to, among other things, wireless payment readers configured to transition between multiple different power states. In some instances, these power states include one or more relatively low-power states such that an overall battery life of the wireless payment readers are lengthened. Further, in some instances, a point-of-sale (POS) application operating on a POS device that wirelessly couples to an example wireless payment reader may cause the wireless payment reader to transition from one state to another, such as from a first, lower-power state to a second, higher-power state in response to the POS application determining that a payment is to be processed using the wireless payment reader.

Abstract: Methods and apparatuses for providing a permissions-aware search and knowledge management system that incorporates user suggested results, document verification, and intelligent user activity tracking across group hierarchies to improve the quality and relevance of search results are described. The permissions-aware search and knowledge management system may enable content stored across a variety of local and cloud-based data stores to be indexed, searched, and displayed to authorized users. The identification and ranking of relevant documents corresponding with a user's search query may take into account user suggested results from the user and others assigned to the same group as the user, whether the underlying content of a search result was verified by a content owner as being up-to-date, the amount of time that has passed since the underlying content was verified by the content owner, and the recent activity of the user and related group members.

Abstract: The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis.

Abstract: The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis.

Abstract: A method of detecting and preventing over current induced system failure is provided. An OC protect controller monitors a CPU total power consumption based on received CPU activity information. In response to the monitoring, if the CPU power consumption is over a threshold, then the OC protect controller outputs a frequency dithering control signal to reduce the CPU clock frequency such that the CPU does not reach an OC limit. The OC protect controller also outputs a PLL frequency control signal to reduce the PLL clock frequency to improve system efficiency.

Abstract: A portable device is provided. A first processor performs an initial procedure according to an operation clock with a first frequency value and an operation voltage with a first voltage value, and performs a calibration procedure according to the operation clock with a second frequency value and the operation voltage with a second voltage value when the initial procedure has been performed and a self-calibration event is present. A second processor detects whether a specific function of the calibration procedure is being performed by the first processor. The second processor stores the second frequency value and the second voltage value into a storage unit after the calibration procedure is performed. The second voltage value is lower than the first voltage value, and the second frequency value is lower than the first frequency value.

Abstract: Systems and methods of low power docking of sleep mode radios are disclosed herein. In an example embodiment, a crystal oscillator is purposefully mistuned to achieve lower power consumption, and then synchronized using a high frequency crystal oscillator. In an alternative embodiment, the input offset voltages of the comparator in an RC oscillator are cancelled, which allows low power operation and high accuracy performance when tuned to the high frequency crystal. A lower power comparator may be used with higher input offset voltages but still achieve higher accuracy. The RC circuit is switched back and forth on opposite phases of the output, cancelling the offset voltage on the inputs of the comparator.

Abstract: Systems and methods of low power clocking of sleep mode radios are disclosed herein. In an example embodiment, a crystal oscillator is purposefully mistuned to achieve lower power consumption, and then synchronized using a high frequency crystal oscillator. In an alternative embodiment, the input offset voltages of the comparator in an RC oscillator are cancelled, which allows low power operation and high accuracy performance when tuned to the high frequency crystal. A lower power comparator may be used with higher input offset voltages but still achieve higher accuracy. The RC circuit is switched back and forth on opposite phases of the output, cancelling the offset voltage on the inputs of the comparator.

Abstract: Systems and methods of low power docking of sleep mode radios are disclosed herein. In an example embodiment, a crystal oscillator is purposefully mistuned to achieve lower power consumption, and then synchronized using a high frequency crystal oscillator. In an alternative embodiment, the input offset voltages of the comparator in an RC oscillator are cancelled, which allows low power operation and high accuracy performance when tuned to the high frequency crystal. A lower power comparator may be used with higher input offset voltages but still achieve higher accuracy. The RC circuit is switched back and forth on opposite phases of the output, cancelling the offset voltage on the inputs of the comparator.

Abstract: A control method for a clock signal for a CPU contained in a CMOS circuit includes: when a load current for the CMOS circuit is enabled, generating a first clock signal; in a first period, selectively gating certain cycles of the first clock signal to generate a second clock signal which has a clock rate less than a clock rate of the first clock signal; and in a second period, dithering in the gated cycles to increase the clock rate of the second clock signal to be equal to that of the first clock signal. The second clock signal is continuously input to the CMOS circuit during the first period and the second period.

Abstract: A method of detecting and preventing over current induced system failure is provided. An OC protect controller monitors a CPU total power consumption based on received CPU activity information. In response to the monitoring, if the CPU power consumption is over a threshold, then the OC protect controller outputs a frequency dithering control signal to reduce the CPU clock frequency such that the CPU does not reach an OC limit. The OC protect controller also outputs a PLL frequency control signal to reduce the PLL clock frequency to improve system efficiency.

Abstract: A portable device is provided. A first processor performs an initial procedure according to an operation clock with a first frequency value and an operation voltage with a first voltage value, and performs a calibration procedure according to the operation clock with a second frequency value and the operation voltage with a second voltage value when the initial procedure has been performed and a self-calibration event is present. A second processor detects whether a specific function of the calibration procedure is being performed by the first processor. The second processor stores the second frequency value and the second voltage value into a storage unit after the calibration procedure is performed. The second voltage value is lower than the first voltage value, and the second frequency value is lower than the first frequency value.

Abstract: The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis.

Abstract: The performance, thermal and power management system is configured to perform DVFS calibration, temperature compensation adjustment, aging calibration, and DC offset calibration in an IC. The initial voltage supplied to the IC maybe set to an initial value which takes chip-to-chip process variations into account and then dynamically adjusted according to temperature variations, DC offset and/or aging effects. Therefore, the performance, thermal and power management system may achieve optimized thermal and power performance of the IC.