Patents by Inventor Alireza Rezania

Alireza Rezania has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • UNIVERSAL DONOR CELLS
    Publication number: 20200080107
    Abstract: Genetically modified cells that are compatible with multiple subjects, e.g., universal donor cells, and methods of generating said genetic modified cells are provided herein. The universal donor cells comprise at least one genetic modification within or near at least one gene that encodes one or more MHC-I or MHC-II human leukocyte antigens or component or transcriptional regulator of the MHC-I or MHC-II complex, at least one genetic modification that increases the expression of at least one polynucleotide that encodes a tolerogenic factor, and optionally at least one genetic modification that increases or decreases the expression of at least one gene that encodes a survival factor.
    Type: Application
    Filed: September 6, 2019
    Publication date: March 12, 2020
    Inventor: Alireza Rezania
  • UNIVERSAL DONOR CELLS
    Publication number: 20200080114
    Abstract: Genetically modified cells that are compatible with multiple subjects, e.g., universal donor cells, and methods of generating said genetic modified cells are provided herein. The universal donor cells comprise at least one genetic modification within or near at least one gene that encodes one or more MHC-I or MHC-II human leukocyte antigens or component or transcriptional regulator of the MHC-I or MHC-II complex, at least one genetic modification that increases the expression of at least one polynucleotide that encodes a tolerogenic factor, and optionally at least one genetic modification that increases or decreases the expression of at least one gene that encodes a survival factor.
    Type: Application
    Filed: September 6, 2019
    Publication date: March 12, 2020
    Inventor: Alireza Rezania
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
    Publication number: 20200048614
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 13, 2020
    Applicant: Janssen Biotech, Inc.
    Inventors: Alireza Rezania, Jean Xu
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
    Publication number: 20200024578
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In particular, the present invention provides an improved method for the formation of pancreatic hormone expressing cells and pancreatic hormone secreting cells. In addition, the present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer and the products related to or resulting from such methods. The present invention also provides methods to promote glucose-stimulated insulin secretion in insulin-producing cells derived from pluripotent stem cells.
    Type: Application
    Filed: September 27, 2019
    Publication date: January 23, 2020
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Methods of enhancing expression of somatostatin in pancreatic endocrine cells
    Patent number: 10519424
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: December 31, 2019
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • ENCAPSULATED INTESTINAL MIDGUT ENDODERM CELLS
    Publication number: 20190365823
    Abstract: Cell populations of intestinal midgut endoderm cells and methods of generating the cells expressing markers characteristic of intestinal endoderm lineage are disclosed. Methods of treating conditions such as diabetes are also disclosed.
    Type: Application
    Filed: August 14, 2019
    Publication date: December 5, 2019
    Applicant: Janssen Biotech, Inc.
    Inventors: Sebastian Rieck, Alireza Rezania
  • Use of a TGF-?R-1 kinase to produce human pancreatic endocrine cells
    Patent number: 10494609
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In particular, the present invention provides an improved method for the formation of pancreatic hormone expressing cells and pancreatic hormone secreting cells. In addition, the present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer and the products related to or resulting from such methods. The present invention also provides methods to promote glucose-stimulated insulin secretion in insulin-producing cells derived from pluripotent stem cells.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: December 3, 2019
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO SINGLE HORMONAL INSULIN POSITIVE CELLS
    Publication number: 20190292523
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides methods to produce a population of cells, wherein greater than 10% of the cells in the population express markers characteristic of single hormonal pancreatic beta cells.
    Type: Application
    Filed: June 7, 2019
    Publication date: September 26, 2019
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
    Patent number: 10420803
    Abstract: Cell populations of intestinal midgut endoderm cells and methods of generating the cells expressing markers characteristic of intestinal endoderm lineage are disclosed. Methods of treating conditions such as diabetes are also disclosed.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: September 24, 2019
    Assignee: Janssen Biotech, Inc.
    Inventors: Sebastian Rieck, Alireza Rezania
  • Methods for making pancreatic endocrine cells
    Patent number: 10421948
    Abstract: The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of MAFA.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: September 24, 2019
    Assignee: Janssen Biotech, Inc.
    Inventors: Alireza Rezania, Benjamin Fryer
  • Differentiation of human embryonic stem cells into single hormonal insulin positive cells
    Patent number: 10358628
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides methods to produce a population of cells, wherein greater than 10% of the cells in the population express markers characteristic of single hormonal pancreatic beta cells.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: July 23, 2019
    Assignee: JANSSEN BIOTECH, INC.
    Inventor: Alireza Rezania
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO PANCREATIC ENDOCRINE CELLS USING HB9 REGULATORS
    Publication number: 20190211309
    Abstract: The present invention provides methods to promote differentiation of pluripotent stem cells to pancreatic endoderm cells expressing PDX1, NKX6.1, and HB9. In particular, the methods encompass culturing Stage 4 to Stage 6 cells with a thyroid hormone (e.g. T3), an ALK5 inhibitor, or both.
    Type: Application
    Filed: November 26, 2018
    Publication date: July 11, 2019
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
    Patent number: 10344264
    Abstract: The present invention provides methods, cell cultures and differentiation media to promote differentiation of pluripotent stem cells to pancreatic endocrine cells expressing PDX1, NKX6.1, and HB9 by culturing in a culture vessel at the air-liquid interface. The invention also provides for in vivo maturation of cells cultured at the air-liquid interface.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 9, 2019
    Assignee: JANSSEN BIOTECH, INC.
    Inventor: Alireza Rezania
  • Methods for purifying cells derived from pluripotent stem cells
    Patent number: 10329534
    Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention provides methods of characterization of cells differentiated into cells expressing markers characteristic of the pancreatic endocrine lineage utilizing unique surface markers. The present invention also provides methods to enrich or sort cells expressing markers characteristic of the pancreatic endocrine lineage. The present invention also provides methods to deplete cells that may contaminate populations of cells expressing markers characteristic of the pancreatic endocrine lineage formed by the methods of the present invention, thereby reducing the incidence of tumor formation in vivo following transplantation.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: June 25, 2019
    Assignee: Janssen Biotech, Inc.
    Inventors: Francis Karanu, Alireza Rezania
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20190169575
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: February 11, 2019
    Publication date: June 6, 2019
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler, Alireza Rezania, Benjamin Fryer
  • Differentiation of human embryonic stem cells into pancreatic endocrine cells
    Patent number: 10208288
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: February 19, 2019
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO PANCREATIC ENDOCRINE CELLS
    Publication number: 20190010465
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Application
    Filed: August 31, 2018
    Publication date: January 10, 2019
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO PANCREATIC ENDOCRINE CELLS
    Publication number: 20190010466
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Application
    Filed: August 31, 2018
    Publication date: January 10, 2019
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO PANCREATIC ENDOCRINE CELLS
    Publication number: 20180371420
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators
    Patent number: 10138465
    Abstract: The present invention provides methods to promote differentiation of pluripotent stem cells to pancreatic endoderm cells expressing PDX1, NKX6.1, and HB9. In particular, the methods encompass culturing Stage 4 to Stage 6 cells with a thyroid hormone (e.g. T3), an ALK5 inhibitor, or both.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: November 27, 2018
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania