Patents by Inventor Alireza Rezania

Alireza Rezania has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Defined media for expansion and maintenance of pluripotent stem cells
    Patent number: 9434920
    Abstract: The present invention provides methods to promote the proliferation of undifferentiated pluripotent stem cells in defined media. Specifically, the invention provides a defined cell culture formulation for the culture, maintenance, and expansion of pluripotent stem cells, wherein culturing stem cells in the defined cell culture formulation maintains the pluripotency and karyotypic stability of the cells for at least 10 passages. Further disclosed is a cell population grown under defined media conditions that express OCT4, SOX2, NANOG, and FOXA2.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: September 6, 2016
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • DEFINED MEDIA FOR EXPANSION AND MAINTENANCE OF PLURIPOTENT STEM CELLS
    Publication number: 20160251615
    Abstract: The present invention provides methods to promote the proliferation of undifferentiated pluripotent stem cells in defined media. Specifically, the invention provides a defined cell culture formulation for the culture, maintenance, and expansion of pluripotent stem cells, wherein culturing stem cells in the defined cell culture formulation maintains the pluripotency and karyotypic stability of the cells for at least 10 passages. Further disclosed is a cell population, grown under defined media conditions, that expresses OCT4, SOX2, NANOG, and FOXA2.
    Type: Application
    Filed: May 9, 2016
    Publication date: September 1, 2016
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Differentiation of human embryonic stem cells into single hormonal insulin positive cells
    Patent number: 9388386
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides methods to produce a population of cells, wherein greater than 10% of the cells in the population express markers characteristic of single hormonal pancreatic beta cells.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: July 12, 2016
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Differentiation of human embryonic stem cells
    Patent number: 9388387
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: July 12, 2016
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Differentiation of Human Pluripotent Stem Cells
    Publication number: 20160160182
    Abstract: The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of MAFA.
    Type: Application
    Filed: December 9, 2015
    Publication date: June 9, 2016
    Applicant: Janssen Biotech, Inc.
    Inventors: Alireza Rezania, Benjamin Fryer
  • DIFFERENTIATION OF PLURIPOTENT STEM CELLS
    Publication number: 20160040130
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method utilizing a CYP26A inhibitor to produce a population of pancreatic endocrine precursor cells.
    Type: Application
    Filed: October 14, 2015
    Publication date: February 11, 2016
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Differentiation of human pluripotent stem cells
    Patent number: 9234178
    Abstract: The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause an increase in expression of MAFA.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: January 12, 2016
    Assignee: Janssen Biotech, Inc.
    Inventors: Alireza Rezania, Benjamin Fryer
  • Differentiation of Human Embryonic Stem Cells into Single Hormonal Insulin Positive Cells
    Publication number: 20150353895
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides methods to produce a population of cells, wherein greater than 10% of the cells in the population express markers characteristic of single hormonal pancreatic beta cells.
    Type: Application
    Filed: August 20, 2015
    Publication date: December 10, 2015
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Use of Small Molecules to Enhance Mafa Expression in Pancreatic Endocrine Cells
    Publication number: 20150329828
    Abstract: The present invention provides methods, cell cultures and differentiation media to promote differentiation of pluripotent stem cells to pancreatic endocrine cells of a mature phenotype. The resulting pancreatic endocrine cells express single hormonal insulin, PDX1, NKX6.1, and MAFA. In one or more differentiation stages, culturing may be carried out in a culture vessel at the air-liquid interface.
    Type: Application
    Filed: May 7, 2015
    Publication date: November 19, 2015
    Applicant: JANSSEN BIOTECH, INC.
    Inventor: Alireza Rezania
  • Differentiation of pluripotent stem cells
    Patent number: 9181528
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method utilizing a CYP26A inhibitor to produce a population of pancreatic endocrine precursor cells.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: November 10, 2015
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
    Publication number: 20150252327
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In particular, the present invention provides an improved method for the formation of pancreatic hormone expressing cells and pancreatic hormone secreting cells. In addition, the present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer and the products related to or resulting from such methods. The present invention also provides methods to promote glucose-stimulated insulin secretion in insulin-producing cells derived from pluripotent stem cells.
    Type: Application
    Filed: May 21, 2015
    Publication date: September 10, 2015
    Applicant: LifeScan, Inc.
    Inventor: Alireza Rezania
  • Differentiation of Human Embryonic Stem Cells
    Publication number: 20150191700
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage.
    Type: Application
    Filed: March 18, 2015
    Publication date: July 9, 2015
    Applicant: JANSSEN BIOTECH, INC.
    Inventor: Alireza Rezania
  • Differentiation of human embryonic stem cells
    Patent number: 9062290
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In particular, the present invention provides an improved method for the formation of pancreatic hormone expressing cells and pancreatic hormone secreting cells. In addition, the present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer and the products related to or resulting from such methods. The present invention also provides methods to promote glucose-stimulated insulin secretion in insulin-producing cells derived from pluripotent stem cells.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: June 23, 2015
    Assignee: LifeScan, Inc.
    Inventor: Alireza Rezania
  • Differentiation of Human Embryonic Stem Cells
    Publication number: 20150159139
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Application
    Filed: March 18, 2014
    Publication date: June 11, 2015
    Applicant: LIFESCAN, INC.
    Inventors: Alireza Rezania, Jean Xu
  • Differentiation of human embryonic stem cells
    Patent number: 9012218
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: April 21, 2015
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Seeding cells on porous supports
    Patent number: 8778673
    Abstract: The present invention generally relates to a method for seeding cells on to a support. In particular, the method relates to a method for seeding cells onto a porous hydrophobic support. The method utilizes centrifugal forces to uniformly guide cell seeding into the support with no loss in viability.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: July 15, 2014
    Assignee: Lifescan, Inc.
    Inventors: Alireza Rezania, Ragae Ghabrial
  • Differentiation of Human Embryonic Stem Cells Into Pancreatic Endocrine Cells Using HB9 Regulators
    Publication number: 20140186953
    Abstract: The present invention provides methods to promote differentiation of pluripotent stem cells to pancreatic endoderm cells expressing PDX1, NKX6.1, and HB9. In particular, the methods encompass culturing Stage 4 to Stage 6 cells with a thyroid hormone (e.g. T3), an ALK5 inhibitor, or both.
    Type: Application
    Filed: December 18, 2013
    Publication date: July 3, 2014
    Applicant: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Differentiation of pluripotent stem cells to definitive endoderm lineage
    Patent number: 8741643
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: June 3, 2014
    Assignee: LifeScan, Inc.
    Inventors: Alireza Rezania, Jean Xu
  • Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
    Patent number: 8691259
    Abstract: A biocompatible tissue repair stimulating implant or “scaffold” device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: April 8, 2014
    Assignee: DePuy Mitek, LLC
    Inventors: Steven M. Bowman, Izi Bruker, Alireza Rezania, Mora Carolynne Melican, Francois Binette, Julia Hwang
  • Differentiation of Human Embryonic Stem Cells into Pancreatic Endocrine Cells
    Publication number: 20130330823
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 12, 2013
    Inventor: Alireza Rezania