Abstract: A pressure vessel with an interior adapted to contain a pressurized substance is provided. The pressure vessel includes a membrane including an interior surface exposed to the interior of the pressure vessel, the membrane adapted to hermetically seal the pressure vessel in an intact state and to release the pressurized substance in a ruptured state. The pressure vessel further includes an actuating rod coupled to and extending from an exterior surface of the membrane on an opposite side of the membrane relative to the interior surface, the actuating rod adapted to transition the membrane from the intact state to the ruptured state in response to receiving a transverse force.

Abstract: A small bore medical device connector is provided. The small bore medical device connector includes a female connector comprising a fluid path and a receptacle configured to accept a male Luer lock connector protrusion extending from a male Luer lock connector. The female connector is configured for threaded engagement to the male Luer lock connector. The male Luer lock connector protrusion includes a standard Luer tapered protrusion and a flow channel therewithin. The male Luer lock connector terminates at a tip disposed at the distal portion. The tip includes an opening to the flow channel. When the female connector is engaged with the male Luer lock connector, a distal aspect of the tip contactingly engages a distal engagement surface in the receptacle to establish a fluid-tight seal and to establish fluid communication through a combined fluid pathway including the fluid path and the flow channel.

Abstract: A package arrangement is provided. The package arrangement includes a package including a compartment defined by a wall. The wall includes a flexible portion. The compartment stores a beneficial agent. The compartment at least partially collapses in response to applied pressure. The compartment is hermetically sealed in a storage configuration. The package includes a rigid insert including a conduit in fluid communication with the compartment. The rigid insert is positioned inside the compartment and includes an insert coupling portion. The package arrangement further includes a rigid frame containing part of the compartment within the rigid frame. The rigid frame includes a frame coupling portion. The insert coupling portion exerts pressure on the frame coupling portion through the flexible portion to restrict motion of the rigid insert relative to the rigid frame. The flexible portion hermetically seals a proximal portion of the conduit in the storage configuration.

Abstract: A beneficial agent dispensing device system is provided. The beneficial dispensing device system includes a dispensing device containing a beneficial agent, an indicium coupled to and selectively decouplable from the dispensing device, the indicium indicating information related to the beneficial agent, and a securing mechanism coupled to the indicium and configurable to secure the indicium to a securable feature.

Abstract: A closed transfer system for transferring metered dose of a beneficial agent from a flexible primary container to a second reservoir or to a patient. The system can be configured to transfer multiple doses.

Abstract: An auto-injector operable in a single activation step. The auto-injector is automatically armed when removed from its carrying receptacle. The auto-injector may be prefilled with more than one constituent of a beneficial agent, stored in separated compartments, in such an arrangement that the compartments will automatically merge when the auto-injector is removed from its carrying receptacle.

Abstract: The disclosure provides a packaging system to store a beneficial agent including a primary package with a molded component. The molded component may have a compartment with a flexible wall enclosing a storage volume and a rigid section configured to connect to a secondary package such that the compartment is contained therewithin. The flexible wall may collapse to deplete a beneficial agent from the storage volume through a dispensing port. The flexible wall may be a web material including a monolayer web or multilayer web, and may incorporate a film, a foil, an adhesive, a polymer layer, a metallic layer, and/or a metal oxide layer. The molded component may be a co-molded component formed of a first material and a second material, the first material being molded into a form and joined to a second material. The molded component may be a unitary molded component which consists of one material.

Abstract: An auto-injector operable to deliver a drug to a patient. The auto-injector may include a storage assembly with a first compartment and second compartment arranged to transition from an initial state in which the first compartment and the second compartment are separated to a merged state. The auto-injector may include a merging trigger configured for actuation responsive to manipulation and a merging mechanism comprising a compression element. Actuation of the merging trigger may cause movement of the merging mechanism such that the compression element compresses the first compartment.

Abstract: A beneficial agent dispensing device comprises a dispenser body comprising a pressure chamber and at least one dispensing port. A flexible primary container stores the beneficial agent contained within the body. The arrangement is such that pressure in the pressure chamber depress the flexible primary container to expel the beneficial agent through the dispensing port. The beneficial agent dispenser can be configured to deliver the beneficial agent intranasally.

Abstract: A cartridge for use with a beneficial agent delivery device having a tillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the tillable reservoir.

Abstract: A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

Abstract: Concentrated tranexamic acid compositions suitable for intramuscular administration via auto-injector are provided. Methods of treating non-compressible hemorrhage are also provided. Kits and auto-injectors comprising the tranexamic acid compositions are further provided.

Abstract: Disclosed is an administration device able to transition between a static state and an advancing state. The administration device includes a stopper and an actuator with a post, both disposed within a hollow body that has a sidewall disposed radially within along its longitudinal length. The actuator and post can move axially within the hollow body. The stopper has a primary wall configured to exert a pressure to seal against the sidewall when the post is in a first position. This seal can provide an aseptic barrier and prevent communication of contaminating particles such as pathogens, pyrogens, viruses, bacteria, and across the seal.

Abstract: A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

Abstract: A beneficial agent dispensing device comprises a dispenser body comprising a pressure chamber and at least one dispensing port. A flexible primary container stores the beneficial agent contained within the body. The arrangement is such that pressure in the pressure chamber depress the flexible primary container to expel the beneficial agent through the dispensing port. The beneficial agent dispenser can be configured to deliver the beneficial agent intranasally.

Abstract: A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Abstract: A dispensing device for use with a beneficial agent has a dispensing package, a dispenser disposed on an end portion of the dispensing package, and an actuator movably disposed along at least a portion of the package between a pre-dispensing state and a dispensing state. One arrangement also provides a beneficial agent dispenser having a dispensing port, an elongate portion and a plunger that is movably disposed relative to a tubular wall of the elongate portion during a dispensing stroke to partially penetrate a separable barrier and expel the beneficial agent through the dispensing port.

Abstract: A dispensing device for use with a beneficial agent has a dispensing package, a dispenser disposed on an end portion of the dispensing package, and an actuator movably disposed along at least a portion of the package between a pre-dispensing state and a dispensing state. One arrangement also provides a beneficial agent dispenser having a dispensing port, an elongate portion and a plunger that is movably disposed relative to a tubular wall of the elongate portion during a dispensing stroke to partially penetrate a separable barrier and expel the beneficial agent through the dispensing port.

Abstract: A package for use with a beneficial agent delivery device. The package includes at least one filling chamber having a sealed penetrable access region, at least one compartment configured to hold a content, wherein the content includes at least one of a beneficial agent or a constituent of a beneficial agent, and at least one channel connecting the at least one filling chamber in fluid communication with the at least one compartment. At least a portion of the package is resealable to contain the content.