Abstract: A controllable drug delivery device for delivering a liquid injectable drug, the device comprising a drug reservoir (22), a drug administration device (28), a displacement-generating battery (20), and a current-depletion circuit (85), wherein displacement generated by the battery as current is depleted from the battery by the current depletion circuit displaces a wall of the drug reservoir thereby causing the reservoir to expel liquid injectable drug contained therein via the drug administration device, and wherein the drug delivery device further includes a controller (78) that is responsive to a measured parameter indicative of displacement generated by the battery for applying a variable load (80) across the battery in order to provide a substantially constant-current depletion of the battery and thereby cause the drug delivery device to deliver a substantially constant drug delivery rate.

Abstract: A hypodermic drug delivery apparatus (10) for delivering a pressurized medication fluid (23) comprising a reservoir (14) containing at least one deliverable fluid (23) and a rupturing member (25) the reservoir (14) having at least one portion of at least one wall (22) rupturable by the rupturing member (25).

Abstract: A dry-powder, breath-powered inhaler device comprising at least one air inlet, a flow chamber and an air outlet leading to a mouthpiece, the flow chamber further comprising at least one drug-containing volume and at least one scraping means and a rotor assembly comprising an axis and at least one blade; wherein the inhalation action of the patient applied at the air outlet causes air to enter the at least one air inlet such that the air interacts with the at least one rotor blade causing the rotor to rotate and thus generate breath-driven, relative motion between the at least one drug-containing volume and the at least one scraping means, such that fine particles of powder are released from the drug-containing volume; the arrangement being such that the air exits the flow chamber via the periphery of the flow chamber, carrying out the fine particles to the outlet to be inhaled by the patient.

Abstract: An at least partially flexible sealed package comprises an opening assembly that includes a sliding component and a lifetime indicator for indicating an expiry status of a product within a storage compartment of the package. Movement of said sliding component relative to the lifetime indicator serving to open a seal of said package and activate the lifetime indicator.

Abstract: A device for measuring fluid flow rates over a wide range of flow rates. The invention is particularly adapted for use in micro-fluidic systems including fluids administration to a body of a patient. The device operates by producing characteristics variations in the fluid, or pulses, that are subsequently sensed by more than one detector spaced apart from the point of creation of the mark to derive a flow rate. Each pulse comprises a small fluid volume, whose characteristics are different from the mean characteristics of the fluid, such as by composition variations created by electrochemical means, such as by electrolysis of a solvent, electrolysis of a dissolved species, or electrodialysis of a dissolved ionic species, or a thermal variation created by focused electromagnetic radiation.

Abstract: The invention provides a liquid dispenser 2 comprising a mostly rigid body including two spaced-apart major surfaces 8 and 10 having interconnected peripheral edges 12 to delimit there between a closed dispensing body having a liquid to be dispensed contained therein, a pumping chamber 5 having an inlet valves 6 and a non-return product dispensing valve 7 and actuated by a pumping button 9 provided along one of the major surfaces 10 and displaceable between a first normal position and a second expressed position, the arrangement being such that the dispenser is formed as a compact, self-contained unitary container and pump, wherein said pumping button 9 is formed as an integral part of one of said major surfaces 10 and serves as a wall of said pumping chamber 5, and depression of the pumping button 9 to its displaced position causes liquid contained in the pumping chamber 5 to be expelled via the product dispensing valve 7, and return of the button to its first normal position causes liquid to enter the pumpi

Abstract: A controllable drug delivery device for delivering a liquid injectable drug, said device comprising a drug reservoir (22), a drug administration device (28), a displacement-generating battery (20), and a current-depletion circuit (85), wherein displacement generated by said battery as current is depleted from the battery by the current depletion circuit displaces a wall of the drug reservoir thereby causing the reservoir to expel liquid injectable drug contained therein via said drug administration device, and wherein the drug delivery device further includes a controller (78) that is responsive to a measured parameter indicative of displacement generated by the battery for applying a variable load (80) across the battery in order to provide a substantially constant-current depletion of said battery and thereby cause said drug delivery device to deliver a substantially constant drug delivery rate.

Abstract: The invention provides a dry-powder inhaler device 10 comprising at least one air inlet 13, a flow chamber 11 and an air outlet 16 leading to a mouthpiece 12, the flow chamber 11 further comprising at least one compressed-powder volumes 19 and a multiplicity of scraping surfaces 18; wherein the inhalation action of the patient applied at the air outlet 16 causes air to flow from the at least one air inlet 13 through the flow chamber 11, the air flow generating relative motion between the compressed-powder volume 19 and the scraping surfaces 18 such that fine particles of powder are scraped from the compressed-powder volume 19 and inhaled by the patient.

Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.

Abstract: An at least partially flexible sealed package having an opening assembly, said opening assembly further comprising a sliding component and a lifetime indicator; the movement of said sliding component serving to open a seal of said package; the arrangement being such that the movement of said sliding component activates said lifetime indicator due to the relative motion between said sliding component and at least part of said lifetime indicator; such that said lifetime indicator can thereby providing a visual indication of the expiry status of the product within said package from the time of opening onwards.

Abstract: A device for measuring fluid flow rates over a wide range of flow rates. The invention is particularly adapted for use in micro-fluidic systems including fluids administration to a body of a patient. The device operates by producing characteristics variations in the fluid, or pulses, that are subsequently sensed by more than one detector spaced apart from the point of creation of the mark to derive a flow rate. Each pulse comprises a small fluid volume, whose characteristics are different from the mean characteristics of the fluid, such as by composition variations created by electrochemical means, such as by electrolysis of a solvent, electrolysis of a dissolved species, or electrodialysis of a dissolved ionic species, or a thermal variation created by focused electromagnetic radiation.

Abstract: A dispensing device comprises a sealed package including a collapsible compartment and an administration assembly. The administration assembly includes a delivery device in fluid communication with a substance within the sealed package. A compression panel collapses the compartment to dispense a substance through the delivery device. Embodiments for a single use dispenser for hypodermic administration of a unit dose of a therapeutic fluid, as well as therapeutic packages and methods for administering therapeutic substances to subjects, are also provided.

Abstract: The invention provides a drug delivery infusion device comprising an injection means (18) in fluid connection with a drug reservoir chamber (12) and pressure-generation means (10) coupled to both the drug reservoir (12) and to a liquid-filled control chamber (13), wherein the coupling is such that the liquid-filled control chamber (13) serves to constrain the motion of the pressure-generation means (10), thereby controlling the drug infusion rate, wherein the liquid-filled control chamber (13) is associated with means for controlled depletion of the liquid therein whereby depletion of the volume of liquid in the control chamber enables the pressure-generation means to drive the drug in the reservoir chamber therefrom for infusion thereof.

Abstract: The present invention provides a drug delivery device comprising a drug reservoir chamber (15) containing a substance (16) to be delivered in fluid connection with a drug administration means (17) and (18), and a hydraulic control chamber (9) containing an electrically controlled, non-gassing, volume changing means (13), a coupling means (14) coupling said hydraulic control chamber (9) to said drug chamber (15), the arrangement being such that a change in the electrical control means (11) causes a change in the volume of the volume changing means (13), the volume change being conveyed by the coupling means (14) to the drug chamber (15) such that the substance (16) is expelled from the drug chamber (15) towards the drug administration means (17) and (18).

Abstract: An at least partially flexible sealed package having an opening assembly, said opening assembly further comprising a sliding component and a lifetime indicator; the movement of said sliding component serving to open a seal of said package; the arrangement being such that the movement of said sliding component activates said lifetime indicator due to the relative motion between said sliding component and at least part of said lifetime indicator; such that said lifetime indicator can thereby providing a visual indication of the expiry status of the product within said package from the time of opening onwards.

Abstract: The invention provides a container (10) having a dispensing outlet (19). A section of the container (10) adjacent to the outlet is provided with a pumping assembly (17) sized to be insertable into the section via the outlet and includes a pumping button (12). The button (12) is a section of the container wall (14) and depression of the button (12) actuates the pumping assembly (17).

Abstract: The present invention provides a liquid dispensing package (10) comprising a flexible film package formed with at least two spaced apart major surfaces joined to each other along their peripheral edges (12) and delimiting therebetween a liquid containing chamber, said package further comprising an integral dosing pump and at least one button (16) to operate the pump. The at least one button (16) is located adjacent to an edge (12) of the package (10).

Abstract: The invention provides a drug delivery infusion device comprising an injection means (18) in fluid connection with a drug reservoir chamber (12) and pressure-generation means (10) coupled to both the drug reservoir (12) and to a liquid filled controlled chamber (13), wherein the coupling is such that the liquid filled control chamber (13) serves to constrain the motion of the pressure-generation means (10), thereby controlling the drug infusion rate, wherein the liquid filled control chamber (13) is associated with means for controlled depletion of the liquid therein whereby depletion of the volume of liquid in the control chamber enables the pressure-generation means to drive the drug in the reservoir chamber therefrom for infusion thereof.

Abstract: The invention provides a liquid dispenser 2 comprising a mostly rigid body including tow spaced-apart major surfaces 8 and 10 having interconnected peripheral edges 12 to delimit there between a closed dispensing body having a liquid to be dispensed contained therein, a pumping chamber 5 having an inlet valves 6 and a non-return product dispensing valve 7 and actuated by a pumping button 9 provided along one of the major surfaces 10 and dispaceable between a first normal position and a second expressed position, the arrangement being such that the dispenser is formed as a compact, self-contained unitary container and pump, wherein said pumping button 9 is formed as an integral part of one of said major surfaces 10 and serves as a wall of said pumping chamber 5, and depression of the pumping button 9 to its displaced position causes liquid contained in the pumping chamber 5 to be expelled via the product dispensing valve 7, and return of the button to its first normal position causes liquid to enter the pumpin