Abstract: A gas turbine engine includes a ceramic wall for bounding an engine core gas path. The ceramic wall has a ceramic wall first side that faces the engine core gas path and a ceramic wall second side that faces away from the engine core gas path. There is a metallic wall adjacent the ceramic wall second side. The metallic wall has a metallic wall first side that faces the ceramic wall and a metallic wall second side that faces away from the ceramic wall. The metallic wall and the ceramic wall are spaced apart such that there is a channel there between. There is a seal on the ceramic wall second side, and the metallic wall has at least one cooling hole adjacent the seal for emitting cooling air to cool the seal.

Abstract: In one exemplary embodiment, a flow path component assembly includes a support structure having an axial portion and a radial portion and an outer portion arranged between the support structure. The outer portion defines a gap between the outer portion and the axial portion of the support structure. A flange is positioned relative to the gap.

Abstract: Fast, efficient, and robust compression-based methods for detecting boundaries in arbitrary datasets, including sequences (1D datasets), are desired. The methods, each employing three simple algorithms, approximate the information distance between two adjacent sliding windows within a dataset. One of the algorithms calculates an initial ordered list of subsequences; while a second algorithm updates the ordered list of subsequences by dropping a first entry and appending a last entry rather than calculating completely new ordered lists with each iteration. Large values in the distance metric are indicative of boundary locations. A smoothed z-score or a wavelet-based algorithm may then be used to locate peaks in the distance metric, thereby identifying boundary locations. An adaptive version of the method employs a collection of window sizes and corresponding weighting functions, making it more amenable to real datasets with unknown, complex, and changing structures.

Abstract: Provided are a computer program product, system, and method for using a machine learning module to rank technical solutions to user described technical problems to provide to a user. A solutions database is searched to determine a result set of answer files having keywords related to keywords of a technical problem in a user description. The result set of answer files, the user description of the technical problem, user profile information, and technical specifications of the computing system are provided as input to a machine learning module. The machine learning module outputs ranks of the answer files in the result set. A subset of answer files in the result set is selected based on ranks of the answer files in the result set and returned to the user.

Abstract: An airfoil vane assembly according to an exemplary embodiment of this disclosure, among other possible things includes a vane piece having a first vane platform, a second vane platform, and a hollow airfoil section joining the first vane platform and the second vane platform, a spar piece having a spar platform and a spar extending from the spar platform into the hollow airfoil section, and at least one seal arranged at a sealing surface of the spar platform and sealing between the spar platform and the first vane platform. The airfoil vane assembly also includes a thermal barrier coating disposed on the spar piece. The sealing surface is free from the thermal barrier coating. A gas turbine engine and a method of making a spar piece for an airfoil vane assembly are also disclosed.

Abstract: Spring energized seal assemblies each with one or two sealing elements and a canted coil spring located in a spring cavity of the sealing element or of the two sealing elements to bias an inner flange and an outer flange of the respective spring cavity away from one another. The canted coil springs can have un-conventional coil shapes with one or more straight coil segments and/or with curved connecting ends. The coils can have dimples to provide multiple biasing points. The coils can have loops. The canted coil springs with un-conventional coil shapes can be used to improve spring loading on a sealing element.

Abstract: A process and system for producing an inoculum for downstream cell production is disclosed. The inoculum is produced in a perfusion bioreactor in which the nutrient media feed is increased as the biomass concentration increases within the bioreactor. A biomass sensor can be used to periodically or continuously monitor biomass concentration. This information can be fed to a controller for automatically increasing nutrient media feed rates in a manner that is directly proportional to producing an inoculum with an increase cell density. The process and system can also include an automated subsystem for maintaining constant volume levels within the perfusion bioreactor during the process.

Abstract: A manifold for control of fluid and/or vapor flow between a container and a pump cartridge for a compounder system is provided. One or more manifolds may be disposed in a magazine configured to secure and align the manifolds with a plurality of ports in the cartridge. Each manifold may include a needle having forward and rear openings to a central bore. A needle housing may include a slot configured to receive a push rod for actuating the needle forward and backward. In a forward, engaged position, the openings in the needle may be disposed on opposite sides of a sealing member of the manifold to form a fluid pathway through the manifold. In a rearward, disengaged position, both the forward and rear openings in the needle may be disposed on the same side of the sealing member to prevent fluid and vapor from flowing through the manifold.

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Abstract: Examples of the disclosed systems and methods may provide for improved and more realistic rendering of virtual characters and a more realistic interaction between a user and virtual characters. For example, the systems and methods describe techniques for mathematically generating a map used for animating facial expressions in a multidimensional animation blendspace. As another example, the systems and methods describe a transition system for dynamically transitioning facial expressions across a face of the virtual character. As another example, realistic physical movements can be added to a virtual character's facial expressions to provide interactivity with other virtual characters.

Abstract: A system for extended time scale event detection includes a data storage device and a processor. The data storage device is configured to store sensor data associated with a vehicle. The processor is configured to analyze an extended time period of the sensor data to identify minor events. The minor events are detected using a minor event threshold. The processor is further configured to determine whether there are more than a threshold number of the minor events and, in the event there are more than a threshold number of the minor events, flag the minor events.

Abstract: Disclosed herein are antigenic peptide-MHC complexes, termed comPACT polypeptides and comPACT polynucleotides, and methods of producing such complexes. Also discloses herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells with high accuracy. Dual particle detection approaches for detection of neoantigen specific T cells with improved sensitivity and specificity are provided. Signal to noise ratio analysis of isolated T cells for detection of neoantigen-specific T cells with improved T cells is also provided.

Abstract: An assembly for a gas turbine engine includes, among other things, an end wall including a main body extending between a first end portion and a second end portion to establish a seal face. The end wall includes a first attachment portion dimensioned to fixedly attach the main body to a static structure at a first attachment point. An airfoil extends radially inwardly from the end wall relative to an assembly axis. The airfoil includes an inner cavity extending between a first end portion and a second end portion, the first end portion adjacent the end wall of the airfoil. A spar member includes a spar body extending between a first end portion and a second end portion. The spar body extends at least partially through the inner cavity. The first end portion of the end wall is cantilevered from the first attachment point.

Abstract: A geo-containment system includes at least one unmanned vehicle and an enforcement system that is onboard the unmanned vehicle and configured to limit travel of the unmanned vehicle based, at least in part, on predefined geospatial operational boundaries. Such boundaries may include a primary boundary and at least one secondary boundary that is spaced apart from the primary boundary a minimum safe distance. The minimum safe distance is determined while the unmanned vehicle is traveling. The minimum safe distance is determined using state information of the unmanned vehicle and/or dynamics of the unmanned vehicle. The state information includes at least position and velocity of the unmanned vehicle. The enforcement system is configured to alter and/or terminate operation of the unmanned vehicle if the unmanned vehicle violates the primary geospatial operational boundary and/or the secondary geospatial boundary.

Abstract: A gas turbine engine includes a ceramic wall for bounding an engine core gas path. The ceramic wall has a ceramic wall first side that faces the engine core gas path and a ceramic wall second side that faces away from the engine core gas path. There is a metallic wall adjacent the ceramic wall second side. The metallic wall has a metallic wall first side that faces the ceramic wall and a metallic wall second side that faces away from the ceramic wall. The metallic wall and the ceramic wall are spaced apart such that there is a channel there between. There is a seal on the ceramic wall second side, and the metallic wall has at least one cooling hole adjacent the seal for emitting cooling air to cool the seal.

Abstract: A gas turbine engine includes a blade outer air seal, a ceramic vane, and a cooling passage circuit that extends through a first internal passage in the blade outer air seal and a second internal passage in the ceramic vane.

Abstract: A vane arc segment includes an airfoil piece that defines first and second platforms and a hollow airfoil section that has an internal cavity and extends between the first and second platforms. The first platform defines a gaspath side, a non-gaspath side, and a flange that projects from the non-gaspath side. Support hardware supports the airfoil piece via the flange. There is a conformal thermal insulation blanket disposed on the flange.

Abstract: The present invention provides methods of treating metabolic diseases including obesity, insulin resistance and type 2 diabetes with inhibitors of COX-2 or VEGFR and lipid prodrugs of COX-2 inhibitors, in particular celecoxib lipid prodrugs, that promote transport of the pharmaceutical agent to the lymphatic system and which enhance release of the parent agent.

Abstract: An airfoil includes a ceramic airfoil that defines a leading edge, a trailing edge, a pressure side, a suction side, a first radial end, and a second radial end. The ceramic airfoil section has an internal cavity and a rib that divides the internal cavity into a first radial passage and a second radial passage. The first radial passage is open at both the first radial end and the second radial end, and the second radial passage is open at least at the second radial end. A cooling passage circuit includes a first radial leg through the first radial passage, a second radial leg though the second radial passage, and a turn leg outside of the internal cavity at the second radial end. The turn leg connects the first radial leg and the second radial leg.

Abstract: An airfoil vane assembly according to an exemplary embodiment of this disclosure, among other possible things includes a vane piece having a first vane platform, a second vane platform, and a hollow airfoil section joining the first vane platform and the second vane platform, a spar piece having a spar platform and a spar extending from the spar platform into the hollow airfoil section, and at least one seal arranged at a sealing surface of the spar platform and sealing between the spar platform and the first vane platform. The airfoil vane assembly also includes a thermal barrier coating disposed on the spar piece. The sealing surface is free from the thermal barrier coating. A gas turbine engine and a method of making a spar piece for an airfoil vane assembly are also disclosed.