Abstract: A surgical stapling device includes an end effector frame and a replaceable reload assembly. The reload assembly includes a reload frame, a cartridge assembly, and an anvil assembly. The reload frame includes a longitudinal portion and a transverse portion that supports the anvil assembly. The longitudinal portion of the reload frame is engaged with the cartridge assembly via interlocking structure that facilitates movement of the cartridge assembly in relation to the anvil assembly between spaced and clamped positions. The reload frame is configured to be received on the end effector frame to properly position the cartridge and anvil assemblies in relation to each other.

Abstract: A maintenance base station includes at least one function component, a man-machine interaction component and a controller. The man-machine interaction component is configured to receive a user input and determine a man-machine interaction signal based on the user input. The man-machine interaction signal indicates a device type and a device task type. A device indicated with the device type at least includes a cleaning robot or the function component of the maintenance base station. The controller electrically connecting the function component and the man-machine interaction component, and is configured to receive the man-machine interaction signal and call the corresponding device to work based on the man-machine intction signal.

Abstract: A conveying device and a medical device. The conveying device includes a catheter mechanism and a limiting body; wherein the catheter mechanism comprises an inner tube assembly and an outer tube, and the outer tube is sleeved on the inner tube assembly and is configured to be movable along an axial direction of the inner tube assembly; the limiting body is connected to a distal outer surface of the inner tube assembly and is configured to expand or contract along a radial direction of the inner tube assembly; the conveying device is configured such that the catheter mechanism is configured to load the medical stent and to release the medical stent when the outer tube moves from distal to proximal, and the limiting body is configured to expand when the medical stent is released so as to position the medical stent in a target position.

Abstract: The present invention discloses a highly reliable implantable device of an implantable biological sensor. Before use, the fixed seat cannot move relative to the slidable seat, achieving reliable transportation. In use, the lower end face of the slidable seat is pressed against the skin; the lower end face of the first snap-fit protrusion squeezes the upper end face of the vertical snap-fit plate; the first snap-fit protrusion is gradually away from the support of the vertical snap-fit plate, whereby the inside vertical face of the vertical snap-fit plate pushes the first snap-fit protrusion inward, and the fixed seat moves downward relative to the slidable seat, achieving good controllability.

Abstract: The present disclosure discloses a guided positioning structure for a sterile adapter and a back end of a surgical instrument. The sterile adapter includes a backboard perpendicular to an upper surface of a body structure of the sterile adapter, the backboard is coupled to the back end of the surgical instrument, and the backboard includes a portion for guiding the back end of the surgical instrument to move in a first direction and a portion for guiding the back end of the surgical instrument to move in a second direction. The guiding and positioning structure for the sterile adapter and the back end of the surgical instrument in the present disclosure limits the range of movement of the back end of the surgical instrument to a smaller width and amplitude when the back end of the surgical instrument is mounted to fit with the sterile adapter.

Abstract: The present disclosure provides a method for improving bioavailability of an NAD+ derivative. The method improves the bioavailability of the NAD+derivative by arranging a CD38 inhibitor and the NAD+ derivative in a same preparation, and controlling the CD38 inhibitor to release first rapidly, and then the NAD+ derivative releases after the CD38 inhibitor has taken effect, thereby increasing the level of NAD+ in vivo.

Abstract: The present disclosure relates to a combined pharmaceutical composition containing a CDK4/6 inhibitor and a use thereof, and specifically relates to a combined pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and fulvestrant. The present disclosure further relates to a use of the combined pharmaceutical composition in treating breast cancer. The combined pharmaceutical composition of the present disclosure produces better therapeutic effects in reducing tumor growth or even eliminating tumors.

Abstract: Described herein are compounds that can arrest mitotic cells and their use in the treatment of disorders such as cancers.

Abstract: Provided herein is a potassium-binding polymer prepared by polymerization reaction of a monomer and a crosslinking agent, wherein the monomer is the compound of formula (V), the crosslinking agent is the compound of formula (VI), and/or the compound of formula (VII), wherein the variables are as defined in the specification; to the use thereof for treating or preventing hyperkalemia.

Abstract: Methods of treating cancer, promoting antigen presentation, or increasing CD8+ T cell infiltration in tumors by inhibiting KDMA5 are provided.

Abstract: The present invention relates to the field of biomedicine, and in particular to a use of goji glycopeptide in the preparation of a drug for preventing and/or treating amyotrophic lateral sclerosis. Experimental results prove the use of goji glycopeptide in the preparation of a drug for preventing and/or treating amyotrophic lateral sclerosis.

Abstract: An instrument driving and transmission mechanism for a surgical robot and an instrument driving and assembly mechanism for the surgical robot are provided. The instrument driving and transmission mechanism includes an instrument drive, a sterile adapter, and a surgical instrument. Adapter transmission members of the sterile adapter and drive transmission members of the instrument drive mesh with each other by means of several teeth that are evenly spaced on surfaces of the adapter transmission members and the drive transmission members, and the adapter transmission members of the sterile adapter cooperate with instrument transmission members of the surgical instrument by means of transmission bosses.

Abstract: The present disclosure provides an MABR-based method for treating rare earth mine tailwater, comprising: introducing rare earth mine tailwater into a sedimentation pond and simultaneously injecting pig farm breeding tailwater into the sedimentation pond, and fully mixing the two in the sedimentation pond for solid particulate sedimentation; performing pH adjustment, MABR enhancement treatment, percolation treatment with a percolation dam, and ecological purification with an ecological purification pond; and overflowing and discharging the rare earth mine tailwater purified by the ecological purification pond to a natural water body.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may determine a new beam ready time that indicates a time at which a beam is to be ready for use in communicating with a base station. The beam may be activated by a downlink control information based beam activation command received by the UE. The UE may communicate with the base station using the beam after the new beam ready time. Numerous other aspects are provided.

Abstract: An example method includes: delivering one or more electrical stimulation pulses to one or more nerves of a patient via one or more inserted electrodes on a lead or formed on an evaluation needle and prior to implantation of an implantable medical device, the one or more nerves being associated with stimulation therapy; sensing an evoked signal generated by one or more signal sources in response to delivery of the one or more electrical stimulation pulses; determining, based at least in part on the evoked signal, a therapy response group of a plurality of therapy response groups for the patient, wherein the therapy response group indicates whether implantation of the implantable medical device is recommended; and outputting information indicative of the determined therapy response group.

Abstract: The present disclosure relates to a power tool and a control method thereof. The power tool includes a drive assembly, a first output portion, a second output portion, a switching assembly to be operated by a user, an identification unit, a control unit, and a control assembly to be triggered by the user. The switching assembly switches one of the first output portion and the second output portion to be connected to the drive assembly, and the identification assembly identifies a working mode of the power tool. In response to a first working mode, the control unit controls the first control assembly to be in an effective state, and the control unit controls an operating state of the first output portion according to a signal input by the first control assembly; in response to a second working mode, the control unit controls the first control assembly to be in an ineffective state.

Abstract: The present disclosure provides a method for photo-curing 4D printing of a multi-layer structure with an adjustable shape recovery speed, and a multi-layer structure printed thereby. The multi-layer structure printed by the method for photo-curing 4D printing of the multi-layer structure with the adjustable shape recovery speed includes a plurality of deformation units sequentially connected in series, and each of the plurality of the deformation units includes two slow layers, a fast layer, and a transition layer; and the fast layer is arranged between the two slow layers, and the transition layer is arranged between at least one of the two slow layers and the fast layer. In the present disclosure, a low cross-linking layer is doped with a nanocarbon light-absorbing material to solve the problem that the low cross-linking layer is prone to over-curing when a high cross-linking layer is printed on the low cross-linking layer.

Abstract: Disclosed is a method for preparing an environmentally-friendly high-strength wood composite material, which includes the following steps: S1. pulverizing wood into a wood flour, adding the wood flour to an acid solution to obtain a first mixture, ball milling the first mixture to obtain a ball milled mixture, and filtering the ball milled mixture, to obtain a dually-treated wood flour; S2. adding the dually-treated wood flour to a first alkaline solution, and performing a neutralization reaction, to obtain a second mixture; S3. adding an alkaline solution to the second mixture to remove part of lignin, to obtain a lignin-partially removed wood flour; S4. washing the lignin-partially removed wood flour with anhydrous ethanol and drying, to obtain a dried lignin-partially removed wood flour; S5. subjecting the dried lignin-partially removed wood flour to hot pressing, followed by cooling, to obtain the environmentally-friendly high-strength wood composite material.

Abstract: The present disclosure relates to a method for treating a cancer and/or cancer metastasis in a subject comprising administering to the subject irinotecan loaded in a mesoporous silica nanoparticle. The present disclosure also provides a conjugate comprising an agent loaded in a mesoporous silica nanoparticle (MSN) defining at least one pore and having at least one functional group on a sidewall of the at least one pore.

Abstract: An example of a neurostimulation system may include a storage device for storing data representing physiological signals and a user interface including a user input, a display screen, and a presentation control circuit. The user input may be configured to receive a selection of signal(s) from the physiological signals and a selection of viewing mode from viewing modes including a metric mode and/or a presence mode. The metric mode allows for visualization of a signal property indicated by a parameter measured from the selected signal(s). The presence mode allows for viewing presence of a feature in the selected signal(s). The presentation control circuit may be configured to allow for the selection of the signal(s) and the viewing mode, to determine a segment of each of the selected signal(s) for presentation according to the selected viewing mode, and to present the determined segment on the display screen.