Patents by Inventor Andrea Leone-Bay

Andrea Leone-Bay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and compositions for delivering active agents
    Patent number: 6642411
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: November 4, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Doris O'Toole
  • Compounds and compositions for delivering active agents
    Patent number: 6623731
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: September 23, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compositions for the delivery of antigens
    Patent number: 6610329
    Abstract: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: August 26, 2003
    Assignee: Emisphere Technologies Inc.
    Inventors: Noemi B. Santiago, Susan Haas, Andrea Leone-Bay, Sam J. Milstein, Evgueni Barantsevitch
  • Compounds and compositions for delivering active agents
    Publication number: 20030149296
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: August 5, 2002
    Publication date: August 7, 2003
    Inventors: Maria Aurora P. Boyd, Andrea Leone-Bay, Doris C. O'Toole
  • Active agent transport systems
    Publication number: 20030133953
    Abstract: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer.
    Type: Application
    Filed: September 25, 2002
    Publication date: July 17, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni Barantsevitch, Andrea Leone-Bay, Nai Fang Wang, Donald J. Sarubbi, Noemi B. Santiago
  • Compounds and compositions for delivering active agents
    Publication number: 20030078302
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
    Type: Application
    Filed: May 8, 2002
    Publication date: April 24, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Pulmonary delivery of active agents
    Publication number: 20030072740
    Abstract: The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.
    Type: Application
    Filed: June 14, 2002
    Publication date: April 17, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, John E. Smart, Donald J. Sarubbi, Monica Leipold, Elizabeth Flanders, Doris O'Toole, Andrea Leone-Bay, David Gschneidner
  • Compounds and compositions for delivering active agents
    Publication number: 20030045579
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Application
    Filed: October 19, 2001
    Publication date: March 6, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compounds and compositions for delivering active agents
    Patent number: 6525020
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: February 25, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, Koc-Kan Ho, David Gschneidner
  • Oral drug delivery compositions and methods
    Publication number: 20030012817
    Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form drug containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
    Type: Application
    Filed: August 20, 2002
    Publication date: January 16, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni N. Barantsevitch, Donald J. Sarubbi, Andrea Leone-Bay, Duncan R. Paton
  • Compounds and compositions for delivering active agents
    Publication number: 20030008900
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: October 31, 2001
    Publication date: January 9, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, Koc-Kan Ho, David Gschneidner
  • Oral drug delivery compositions and methods
    Patent number: 6461643
    Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: October 8, 2002
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni N. Barantsevitch, Donald J. Sarubbi, Andrea Leone-Bay, Duncan R. Paton
  • Compounds and compositions for delivering active agents
    Publication number: 20020127202
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: November 7, 2001
    Publication date: September 12, 2002
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Sam J. Milstein, Donald J. Sarrubi, Harry Leipold
  • Compounds and compositions for delivering active agents
    Publication number: 20020119910
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: December 19, 2000
    Publication date: August 29, 2002
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, Koc-Kan Ho, David Gschneidner, Eugene N. Barantsevich
  • Compounds and compositions for delivering active agents
    Publication number: 20020120009
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: February 21, 2002
    Publication date: August 29, 2002
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Pulmonary delivery of active agents
    Patent number: 6440929
    Abstract: The present invention relates to pulmonary delivery of active agents. Acylated or sufonated amino acids are used as carriers to facilitate pulmonary delivery of active agents to a target.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: August 27, 2002
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, John E. Smart, Donald J. Sarubbi, Monica Leipold, Elizabeth Flanders, Doris O'Toole, Andrea Leone-Bay, David Gschneidner
  • Compounds and compositions for delivering active agents
    Patent number: 6428780
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: August 6, 2002
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein, Nai Fang Wang
  • Oral drug delivery compositions and methods
    Publication number: 20020052422
    Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
    Type: Application
    Filed: May 21, 2001
    Publication date: May 2, 2002
    Applicant: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni N. Barantsevitch, Donald J. Sarubbi, Andrea Leone-Bay, Duncan R. Paton
  • Compounds and compositions for delivering active agents
    Publication number: 20020040061
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: August 24, 2001
    Publication date: April 4, 2002
    Applicant: EMISPHERE TECHNOLOGIES, INC
    Inventors: Pingwah Tang, Andrea Leone-Bay, David Gschneidner
  • Compounds and compositions for delivering active agents
    Patent number: 6358504
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: March 19, 2002
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, Koc-Kan Ho, David Gschneidner