Patents by Inventor Andrea Leone-Bay

Andrea Leone-Bay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diketopiperazine salts for drug delivery and related methods
    Patent number: 7820676
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: October 26, 2010
    Assignee: MannKind Corporation
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • Compounds and compositions for delivering active agents
    Patent number: 7744910
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: June 29, 2010
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, Lynn Errigo, Koc-Kan Ho, Jeffrey Bruce Press, Nai Fang Wang, Pingwah Tang
  • Delivery of Active Agents
    Publication number: 20090111749
    Abstract: A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.
    Type: Application
    Filed: October 24, 2008
    Publication date: April 30, 2009
    Inventors: Peter Richardson, Robert A. Baughman, Andrea Leone-Bay, Donald Costello
  • GLUCAGON-LIKE PEPTIDE 1 (GLP-1) PHARMACEUTICAL FORMULATIONS
    Publication number: 20080260838
    Abstract: A composition is disclosed comprising glucagon-like peptide 1 (GLP-1) particles in combination with diketopiperazine (DKP) that is stable both in vitro and in vivo. The composition has utility as a pharmaceutical formulation for treating diseases such as diabetes, cancers, and obesity but is not limited to such diseases or conditions. In particularly, the composition has utility as a pharmaceutical formulation for pulmonary delivery.
    Type: Application
    Filed: April 16, 2007
    Publication date: October 23, 2008
    Applicant: MANNKIND CORPORATION
    Inventors: Mark J. Hokenson, David Brandt, Mark King, Stephanie Greene, Mary Faris, Keith Oberg, Wayman Wendell Cheatham, Cohava Gelber, Andrea Leone-Bay
  • Compounds and Compositions for Delivering Active Agents
    Publication number: 20080255250
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: May 16, 2005
    Publication date: October 16, 2008
    Applicant: Emisphere Technologies, Inc.
    Inventors: Maria Isabel Gomez-Orellana, David Gschneidner, Andrea Leone-Bay, Destardi Moye-Sherman, Stephen V. Pusztay, Parshuram Rath, Pingwah Tang, John J. Weidner, Jianfeng Song
  • Compounds and compositions for delivering active agents
    Patent number: 7417022
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: April 11, 2005
    Date of Patent: August 26, 2008
    Assignee: MHR Institutional Partners IIA LP
    Inventors: Andrea Leone-Bay, Sam J. Milstein, Donald J. Sarubbi, Harry Leipold
  • Phenyl amine carboxylic acid compounds and compositions for delivering active agents
    Patent number: 7279597
    Abstract: Phenyl amine carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: October 9, 2007
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Kelly Kraft, Maria A. P. Boyd
  • COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
    Publication number: 20070087958
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: November 8, 2006
    Publication date: April 19, 2007
    Applicant: Emisphere Technologies, Inc.
    Inventors: Maria Boyd, Andrea Leone-Bay, Doris O'Toole
  • Compounds and compositions for delivering active agents
    Patent number: 7186414
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: March 6, 2007
    Assignee: Emisphere Technologies, Inc
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, Lynn Errigo, Koc-Kan Ho, Jeffrey Bruce Press, Nai Fang Wang, Pingwah Tang
  • COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
    Publication number: 20070010422
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: September 13, 2006
    Publication date: January 11, 2007
    Applicant: Emisphere Technologies, Inc.
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, Lynn Errigo, Koc-Kan Ho, Jeffrey Press, Nai Wang, Pingwah Tang
  • Compounds and compositions for delivering active agents
    Patent number: 7151191
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: December 19, 2006
    Assignee: Emisphere Technologies, Inc.
    Inventors: Maria Aurora P. Boyd, Andrea Leone-Bay, Doris C. O'Toole
  • PHENOXY CARBOXYLIC ACID COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
    Publication number: 20060264513
    Abstract: Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: July 18, 2006
    Publication date: November 23, 2006
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Kelly Kraft, Destardi Moye-Sherman, David Gschneidner, Maria Boyd, Puchun Liu, Pingwah Tang, Jun Liao, John Smart, John Freeman
  • Phenoxy carboxylic acid compounds and compositions for delivering active agents
    Patent number: 7129274
    Abstract: Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: October 31, 2006
    Assignee: Emisphere Technologies Inc.
    Inventors: Andrea Leone-Bay, Kelly Kraft, Destardi Moye-Sherman, David Gschneidner, Maria A. P. Boyd, Puchun Liu, Pingwah Tang, Jun Liao, John J. Freeman, Jr., John E. Smart
  • Compounds and compositions for delivering active agents
    Patent number: 7125910
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: October 24, 2006
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, David Gschneidner, Koc-Kan Ho
  • Compounds and compositions for delivering active agents
    Patent number: 7067119
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: June 27, 2006
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Oral drug delivery compositions and methods
    Publication number: 20060134130
    Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
    Type: Application
    Filed: November 1, 2005
    Publication date: June 22, 2006
    Applicant: Emisphere Technologies, Inc.
    Inventors: Sam Milstein, Evgueni Barantsevitch, Donald Sarubbi, Andrea Leone-Bay, Duncan Paton
  • Pulmonary delivery of inhibitors of phosphodiesterase type 5
    Publication number: 20060099269
    Abstract: Provided herein are compositions of 1) diketopiperazine salts of PDE5 inhibitors, and 2) DKP microparticles having a PDE5 inhibitors thereon, as well as methods for the pulmonary delivery of these compositions for the treatment of pulmonary hypertension and sexual dysfunction(s).
    Type: Application
    Filed: August 23, 2005
    Publication date: May 11, 2006
    Applicant: MannKind Corporation
    Inventors: Wayman Cheatham, Andrea Leone-Bay, Marshall Grant, Per Fog, David Diamond
  • Oral drug delivery compositions and methods
    Patent number: 7005141
    Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form drug containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: February 28, 2006
    Assignee: Emisphere Technologies Inc.
    Inventors: Sam J. Milstein, Evgueni N. Barantsevitch, Donald J. Sarubbi, Andrea Leone-Bay, Duncan R. Paton
  • Diketopiperazine salts for drug delivery and related methods
    Publication number: 20060040953
    Abstract: Biologically active agent delivery compositions, which comprise diketopiperazine carboxylate salts are provided. Related methods for making and using the biologically active agent delivery compositions are also provided.
    Type: Application
    Filed: August 23, 2005
    Publication date: February 23, 2006
    Applicant: MannKind Corporation
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan Wilson
  • Compounds and compositions for delivering active agents
    Patent number: 6991798
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: January 31, 2006
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, Lynn Errigo, Koc-Kan Ho, Jeffrey Bruce Press, Nai Fang Wang, Pingwah Tang