Patents by Inventor Andrea Leone-Bay

Andrea Leone-Bay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and compositions for delivering active agents
    Publication number: 20050272638
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: June 30, 2005
    Publication date: December 8, 2005
    Applicant: Emisphere Technologies, Inc.
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, Lynn Errigo, Koc-Kan Ho, Jeffrey Press, Nai Wang, Pingwah Tang
  • Compounds and compositions for delivering active agents
    Publication number: 20050272815
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
    Type: Application
    Filed: June 29, 2005
    Publication date: December 8, 2005
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald Sarubbi, Sam Milstein
  • Compounds and compositions for delivering active agents
    Patent number: 6972300
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: December 6, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Active agent transport systems
    Publication number: 20050255138
    Abstract: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety.
    Type: Application
    Filed: January 24, 2005
    Publication date: November 17, 2005
    Inventors: Sam Milstein, Evgueni Barantsevitch, Andrea Leone-Bay, Nai Wang, Donald Sarubbi, Noemi Santiago
  • Compounds and compositions for delivering active agents
    Patent number: 6960355
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: November 1, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Sam J. Milstein, Donald J. Sarrubi, Harry Leipold
  • Compounds and compositions for delivering active agents
    Publication number: 20050186176
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: April 11, 2005
    Publication date: August 25, 2005
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Sam Milstein, Donald Sarrubi, Harry Leipold
  • Active agent transport systems
    Patent number: 6916489
    Abstract: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: July 12, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni Barantsevitch, Andrea Leone-Bay, Nai Fang Wang, Donald J. Sarubbi, Noemi B Santiago
  • Compounds and compositions for delivering active agents
    Publication number: 20050101671
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
    Type: Application
    Filed: July 9, 2003
    Publication date: May 12, 2005
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald Sarubbi, Sam Milstein
  • Compounds and compositions for delivering active agents
    Publication number: 20050042274
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: December 31, 2003
    Publication date: February 24, 2005
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, John Freeman, Doris O'Toole, Lynn Shields
  • Compounds and compositions for delivering active agents
    Publication number: 20040110839
    Abstract: Modified, amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Application
    Filed: July 18, 2003
    Publication date: June 10, 2004
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compounds and compositions for delivering active agents
    Publication number: 20040068013
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 8, 2004
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compositions for the delivery of antigens
    Publication number: 20040062773
    Abstract: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
    Type: Application
    Filed: June 19, 2003
    Publication date: April 1, 2004
    Applicant: Emisphere Technologies Inc.
    Inventors: Noemi B. Santiago, Susan Haas, Andrea Leone-Bay, Sam J. Milstein, Evgueni Barantsevitch
  • Compounds and compositions for delivering active agents
    Patent number: 6699467
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: March 2, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compounds and compositions for delivering active agents
    Patent number: 6693208
    Abstract: Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: February 17, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gscheidner, Andrea Leone-Bay, Eric Wang, John J. Freeman, Doris C. O'Toole, Lynn Shields
  • Pulmonary delivery of active agents
    Patent number: 6693073
    Abstract: The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: February 17, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, John E. Smart, Donald J. Sarubbi, Monica Leipold, Elizabeth Flanders, Doris O'Toole, Andrea Leone-Bay, David Gschneidner
  • Compounds and compositions for delivering active agents
    Publication number: 20030235612
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: February 24, 2003
    Publication date: December 25, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, David Gschneidner, Koc-Kan Ho
  • Compounds and compositions for delivering active agents
    Patent number: 6663887
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: December 16, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compounds and compositions for delivering active agents
    Publication number: 20030225300
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: June 20, 2003
    Publication date: December 4, 2003
    Applicant: Emisphere Technologies Inc.
    Inventors: Andrea Leone-Bay, Doris O'Toole
  • Compounds and compositions for delivering active agents
    Publication number: 20030216589
    Abstract: Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
    Type: Application
    Filed: July 15, 2002
    Publication date: November 20, 2003
    Inventors: David Gschneidner, Andrea Leone-Bay, Eric Wang, John J. Freeman, Doris C. O'Toole, Lynn Shields
  • Compounds and compositions for delivering active agents
    Patent number: 6646162
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: November 11, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Pingwah Tang, Andrea Leone-Bay, David Gschneidner