Patents by Inventor Andrea Leone-Bay

Andrea Leone-Bay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RAPID AND CONTROLLED DELIVERY OF COMPOSITIONS WITH RESTORED ENTOURAGE EFFECTS
    Publication number: 20200101034
    Abstract: Fast-acting oral formulations with restored entourage effects are described. The formulations include beneficial combinations of plant-derived molecules to provide restored entourage effects, and one or more carriers. The carriers can include N-acylated fatty amino acids, absorption enhancers, and/or various other beneficial carriers. The fast-acting oral formulations can create administration benefits.
    Type: Application
    Filed: March 23, 2018
    Publication date: April 2, 2020
    Applicant: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Fast-acting plant-based medicinal compounds and nutritional supplements
    Patent number: 10588974
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 17, 2020
    Assignee: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • FAST-ACTING PLANT-BASED MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS
    Publication number: 20200078332
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: October 6, 2017
    Publication date: March 12, 2020
    Applicant: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Diketopiperazine salts for drug delivery and related methods
    Patent number: 10583176
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: March 10, 2020
    Assignee: Mannkind corporation
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • HEAT-STABLE DRY POWDER PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20190358163
    Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.
    Type: Application
    Filed: August 1, 2019
    Publication date: November 28, 2019
    Inventors: Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay
  • MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS
    Publication number: 20190336472
    Abstract: Synthetic cannabinoid medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The synthetic cannabinoid composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: January 3, 2018
    Publication date: November 7, 2019
    Applicant: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Heat-stable dry powder pharmaceutical compositions and methods
    Patent number: 10413513
    Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: September 17, 2019
    Assignee: Mannkind Corporation
    Inventors: Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay
  • Delivery of Active Agents
    Publication number: 20190167580
    Abstract: A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.
    Type: Application
    Filed: February 4, 2019
    Publication date: June 6, 2019
    Inventors: Peter Richardson, Robert A. Baughman, Andrea Leone-Bay, Donald Costello
  • FAST-ACTING PLANT-BASED MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS
    Publication number: 20190117778
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: April 21, 2017
    Publication date: April 25, 2019
    Applicant: RECEPTOR LIFE SCIENCES, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Methods and compositions for treating pain
    Patent number: 10258664
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 16, 2019
    Assignee: MannKind Corporation
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • DIKETOPIPERAZINE SALTS FOR DRUG DELIVERY AND RELATED METHODS
    Publication number: 20190030133
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Application
    Filed: October 4, 2018
    Publication date: January 31, 2019
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • Inhalable vaccine compositions and methods
    Patent number: 10159644
    Abstract: Dry powder inhalable compositions and methods for using and making the compositions are disclosed for vaccinating a subject against disease. In particular, the compositions are inhalable dry powders useful for preventing and/or treating diseases caused by microorganisms, for example, microorganisms such as viral or bacterial pathogens, including, the influenza virus. In particular, the method comprises the administration of an inhalable composition comprising virus-like particles and/or specific protein/s or antigenic peptides, peptide fragments and/or derivatives thereof using a dry powder drug delivery system.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: December 25, 2018
    Assignees: MannKind Corporation, Technovax, Inc.
    Inventors: Chad C. Smutney, Andrea Leone-Bay, Jose M. Galarza, Hector Munoz, George R. Martin, Marshall L. Grant
  • Diketopiperazine salts for drug delivery and related methods
    Patent number: 10130685
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: November 20, 2018
    Assignee: MannKind Corporation
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • HEAT-STABLE DRY POWDER PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20180221280
    Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.
    Type: Application
    Filed: January 31, 2018
    Publication date: August 9, 2018
    Inventors: Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay
  • Heat-stable dry powder pharmaceutical compositions and methods
    Patent number: 9925144
    Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: March 27, 2018
    Assignee: MannKind Corporation
    Inventors: Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay
  • Diketopiperazine salts for drug delivery and related methods
    Publication number: 20170274050
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • METHOD AND COMPOSITION FOR TREATING MIGRAINES
    Publication number: 20170232001
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Application
    Filed: February 28, 2017
    Publication date: August 17, 2017
    Inventors: Andrea Leone-Bay, Grayson W. Stowell, Joseph J. Guarneri, Dawn M. Carlson, Marshall Grant, Chad C. Smutney
  • METHODS AND COMPOSITIONS FOR TREATING PAIN
    Publication number: 20170209525
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Application
    Filed: February 22, 2017
    Publication date: July 27, 2017
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • Diketopiperazine salts for drug delivery and related methods
    Patent number: 9675674
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: June 13, 2017
    Assignee: MannKind Corporation
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • Methods and compositions for treating pain
    Patent number: 9610351
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: April 4, 2017
    Assignees: MannKind Corporation, TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell