Abstract: The disclosed technology provides techniques, systems, and apparatus for proactively detecting, containing, and recovering from uncorrectable memory errors in distributed computing environment. An aspect of the disclosed technology includes scanning, by a scanner of a host machine, memory of the host machine for errors. After the scanner detects an error, the scanner may generate an error notification. The scanner may transmit the error notification to one or more processors of the host machine to implement mitigation techniques.

Abstract: In a handrail including a carcass, a stretch inhibitor within the carcass, and a sliding layer bonded to the carcass, at least a portion of the carcass has a gas phase dispersed in a solid polymer matrix. The gas phase can reduce a density of the carcass by at least 5% or 10%, or about 15%, as compared to a density of the polymer matrix. The carcass can have a generally uniform distribution of gas bubbles in the polymer matrix, which can define a generally closed cell structure in the polymer matrix. The gas phase can be formed of particles of a syntactic foam dispersed in the polymer matrix. The handrail can further include a cover. The carcass and the cover can be formed of thermoplastic materials, and the cover can represent between 10 and 30% of the overall TPU required for the handrail.

Abstract: Disclosed are devices for determining an analyte concentration. The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and an electronics unit operatively connected to the sensor. The electronics unit may be engaged with a housing that may secure the device to a host's skin. In this regard, in one embodiment, the housing may be attached to an adhesive patch that is fastened to the skin of the host.

Abstract: A notched filter includes a multilayer having alternating first and second polymer layers, the first polymer layers each including an isotropic polymer thin film having in-plane refractive indices n1x and n1y, and the second polymer layers each including an isotropic or anisotropic polymer thin film having in-plane refractive indices n2x and n2y, where a thickness of each successive first polymer layer decreases with increasing distance from a centerline of the multilayer, and a thickness of each successive second polymer layer increases with increasing distance from the centerline. Such a filter may be configured to reflect incident light having a desired polarization state within a predetermined and relatively narrow band.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: The present disclosure generally relates to underwater user interfaces.

Abstract: This disclosure pertains to compounds, the preparation thereof, and the use of these compounds in the treatment of prostate cancer, including metastatic and/or castrate-resistant prostate cancer, in subjects in need thereof.

Abstract: Described herein are compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof. Also disclosed are compositions containing the compounds, methods of inhibiting activity of DYRK1A in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: Described are systems and methods for monitoring, detecting, and/or protecting various systems of an aerial vehicle, such as an unmanned aerial vehicle (UAV). Embodiments of the present disclosure can provide a multi-tiered system to provide monitoring, detection, and/or initiation of protection protocols in response to detected faults in connection with the electronics associated with UAV systems, such as the motor drive and/or control systems that may drive the propulsion systems of the UAV.

Abstract: The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: An electronic device can include a housing, an audio component, and a gasket. The housing can define a first internal volume and the audio component can define a second internal volume. The audio component can include membrane and a venting element having a fluid impermeable layer. The venting element can define a fluid path placing the first internal volume and the second internal volume in fluid communication. At least a portion of the fluid path can extend parallel to the fluid impermeable layer. The gasket can define a seal between the first internal volume and an ambient environment adjacent the housing.

Abstract: Disclosed herein are systems (e.g., moving bed redox systems) and methods for supplying thermal energy to an endothermic chemical process.

Abstract: A method of imaging a turbine engine test component with a first surface and a second surface that is spaced from the first surface. The turbine engine test component includes a plurality of film holes with inlets formed in the second surface or interior that are fluidly coupled to outlets formed in the first surface or exterior. The method includes flowing airflow through the plurality of film holes of the turbine engine test component, obtaining thermographic data, determining a test dataset, and calculating a performance score.

Abstract: The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

Abstract: The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3K?) and are useful in the treatment of diseases related to the activity of PI3K? including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract: An integrated circuit apparatus includes a substrate and a well contact that is disposed on the substrate. The well contact includes first and second source/drain structures that are disposed on the substrate; a metal vertical portion that contacts the substrate immediately between the first and second source/drain structures; inner spacers that electrically insulate the vertical portion from the adjacent source/drain structures; bottom dielectric isolation that electrically insulates the source/drain structures from the substrate; and a well portion that is embedded into the substrate in registry with the vertical portion. The well portion is doped differently than the substrate.

Abstract: A catheter assembly is provided having a working lumen and a guide. The guide is configured to position a fragmentizing device within the working lumen. The guide is configured to prevent or minimize any unintended movement of a distal section of the fragmentizing device within the working lumen when the distal section of the fragmentizing device is positioned at a distal end of the working lumen.

Abstract: Described herein are functionalized cells comprising an immune checkpoint molecule covalently attached to the cell surface or to a nanoparticle attached to the cell surface, and compositions comprising the functionalized cells. Also described are acellular pancreatic extracellular matrices comprising a functionalized cell(s) and decellularized pancreatic-derived protein(s). Also described are methods of treating disease by administering to subjects the functionalized cells and acellular pancreatic extracellular matrices. Also described are methods of making the functionalized cells and acellular pancreatic extracellular matrices described herein.