Abstract: The present disclosure pertains to methods for producing aflibercept from a host cell cultured in a chemically defined medium (CDM) including purification of aflibercept, wherein aflibercept following purification includes aflibercept variants that have at least one oxidized amino acid residue selected from the group consisting of tryptophan, histidine and a combination thereof.

Abstract: Aspects of a storage device including a memory and a controller are provided. The controller may determine to perform garbage collection on a superblock. During the garbage collection process, the controller will typically move the superblock into an erase pool for erasing the superblock. However, aspects of the disclosure are directed to a method of measuring a raw bit error rate (RBER) of the superblock prior to erasure. The measured RBER may be used to estimate a data retention time of the storage device and provide the customer with an early warning notification if a health metric of the storage devices reaches a threshold retention time.

Abstract: The disclosed technologies include a robotic selling assistant that receives an item from a seller, automatically generates a posting describing the item for sale, stores the item until it is sold, and delivers or sends the item out for delivery. The item is placed in a compartment that uses one or more sensors to identify the item, retrieve supplemental information about the item, and take pictures of the item for inclusion in the posting. A seller-supplied description of the item may be verified based on the retrieved supplemental information, preventing mislabeled items from being sold.

Abstract: Various methods of making low-tortuosity electrodes are disclosed. In some embodiments, the low-tortuosity electrodes have a tortuosity of less than 2.0 or 1.4 and include battery-active material and solid electrolyte with the solid electrolyte having channels therein that are vertically aligned. A solid-state lithium-ion battery electrode is also disclosed.

Abstract: In some aspects, the described systems and methods provide for validating performance of a model trained on a plurality of annotated pathology images. A pathology image is accessed. Frames are generated using the pathology image. Each frame in the set includes a distinct portion of the pathology image. Reference annotations are received from one or more users. The reference annotations describe at least one of a plurality of tissue or cellular characteristic categories for one or more frames in the set. Each frame in the set is processed using the trained model to generate model predictions. The model predictions describe at least one of the tissue or cellular characteristic categories for the processed frame. Performance of the trained model is validated based on determining a degree of association between the reference annotations and the model predictions for each frame and/or across all frames in the set of frames.

Abstract: Systems, methods, and storage media for pre-approving onboarding to a payment platform, executing on a processing device are disclosed. Exemplary implementations may: access a node network; determine a first entity associated with a first node of the plurality of nodes is not a member of a payment platform; determine a total strength of connections of the first node to one or more nodes of the plurality of nodes exceeds a predetermined threshold value; and flag the first node of the plurality of nodes for an offer of onboarding to the payment platform consequent to determining the total strength of connections of the first node to the one or more nodes of the plurality of nodes exceeds the predetermined threshold value.

Abstract: A system and method for extracting data from an electronic health record to provide provider and patient data similarity scoring includes: encoding a problem list for a plurality of patients with concepts from a common electronic health record ontology. In one aspect, the patients have electronic health records maintained by a plurality of providers. The system and method then may parse the concepts into a plurality of clusters or categories and determining, for each of the providers, a total number of patients that have at least one problem in a cluster or category or determining, for each patient, which of the plurality of clusters or categories correspond to at least one concept encoded in the patient's problem list. The system and method then may calculate for each pair of providers or patients, a distance between the providers or patients.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: A computer-implemented method of monitoring security of a set of computing devices in a distributed system, the distributed system having a plurality of computing devices, in communication with one another over a network, by a security software running in a computer node. The method includes comparing an app signature of the application running in a selected one of the set of computing devices to a reference app signatures generated from a respective functional replica of the application.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: Under Backend Application Session Management (“BASM”), a DBMS not only creates an application session but also the respective adjunct security context to which to attach the adjunct security context. The middle tier does not need to create the application session or its adjunct security context. Instead, the middle tier sends an end-user token that the middle tier piggybacks to database requests that are sent through database connections. The end-user token identifies an end user and has been authenticated by the middle tier. The generation of the end-user token is concomitant to the process of the middle tier authenticating the end user. The DBMS invokes a user-defined function to generate an adjunct security context. The user-defined function generates the adjunct security context based on the end-user token. Application developers can customize the user-defined function to customize backend security for their needs.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least one first targeting agent which binds a first target on an NK cell surface, and at least one second targeting agent which binds a second target on a cancer cell surface, wherein the second targeting agent is different from the first targeting agent.

Abstract: Disclosed herein are antigen-capturing nanoparticles. Specifically, the subject matter contained herein pertains to novel nanoparticles that can capture a multitude of tumor antigens that are released from tumor cells. Also, provided herein are methods for preparing the antigen-capturing nanoparticles and methods for the treatment of disease in a subject comprising administering the antigen-capturing nanoparticles.

Abstract: In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Abstract: The disclosure includes compounds of Formula (I): wherein R1, R2, and R3, are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: A computer-implemented method of monitoring security of a set of computing devices in a distributed system, the distributed system having a plurality of computing devices, in communication with one another over a network, by a security software running in a computer node. The method includes comparing an app signature of the application running in a selected one of the set of computing devices to a reference app signatures generated from a respective functional replica of the application.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: A control device to provide control of electrical devices based on timing information. The control device stores device operational information which indicates an association between timing information and a plurality of operational modes for each of a set of electrical devices associated with a physical space. The control device detects a presence of a user within the physical space. The user is associated with an electronic apparatus. The control device further compares other timing information captured at a time of the detection of the presence of the user with the timing information. The control device determines an operational mode from the plurality of operational modes for each of the set of electrical devices based on the comparison. The control device further controls each of the set of electrical devices based on the determined operational mode.

Abstract: The present invention provides compositions and methods for reducing inflammation. In one aspect, the present invention provides a protein inhibitor comprising an ectodomain of at least one TREM or TREML protein. The invention also relates to inhibiting the interaction between a TREM or TREML protein and mitochondria released or derived from necroptotic cells; or between a TREM or TREML protein and cardiolipin.