Abstract: The invention uses a PID controller engine to provide a desired distribution of targeted ad placements, including controlling campaign pace in realtime to precisely spend a campaign budget over a prescribed runtime, while producing optimum results in a cost efficient manner based on desired targeting parameters. Those parameters include one or more probabilities that a viewer associated with an ad impression opportunity: belongs to one or more targeted demographic categories; will convert with respect to a product or service being offered; has an intention to buy the product or service; or exhibits one or more defined behaviors. Probabilities are determined by a truth-based machine-learning modelling engine. Upon receiving an ad slot opportunity package, a DSP makes a bid decision and determines a bid price, and then sends a bid response to the supply-side partner, all within 200 mS of receiving the ad slot opportunity or the bid will be ignored.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: A computer-implemented method designs a distributed heterogeneous computing and control system, including both an application and a hardware context and configuring the application in the hardware context. The method is implemented by design software instructions executing in a computer node, associated with an interactive display, to establish an interactive environment utilizing computer processes. The computer processes provide access in the interactive environment to a set of functional modules and a set of primitive modules. The computer processes receive the interactive environment a selection of desired ones of the functional modules and the primitive modules and order them in a manner to characterize the distributed computing and control system as a schematic of a set of devices. The computer processes parse the schematic to produce a set of sub-schematics that each correspond to a distinct device in a set of devices in the distributed computing and control system.

Abstract: A method for fabricating a microelectromechanical system device. Submerging a microelectromechanical system device in water. The microelectromechanical system devices include a sacrificial layer deposited on the surface of a substrate between the portion of a structural layer to be freed for movement and a base. Anodically etching the sacrificial layer from the microelectromechanical device to free the portion of the structural layer for movement. A system comprising a solution of water, a microelectromechanical system device including a sacrificial layer of chromium deposited on the surface of a substrate between a portion of a structural layer and a base. The microelectromechanical system device is submerged in the solution of water. An electrode is submerged in the water. The electrode provides a negative bias. A voltage source provides a positive bias to the sacrificial layer of chromium, anodically etching the sacrificial layer of chromium and freeing the portion of the structural layer.

Abstract: A method for fabricating a microelectromechanical system device. Submerging a microelectromechanical system device in water. The microelectromechanical system devices include a sacrificial layer deposited on the surface of a substrate between the portion of a structural layer to be freed for movement and a base. Anodically etching the sacrificial layer from the microelectromechanical device to free the portion of the structural layer for movement. A system comprising a solution of water, a microelectromechanical system device including a sacrificial layer of chromium deposited on the surface of a substrate between a portion of a structural layer and a base. The microelectromechanical system device is submerged in the solution of water. An electrode is submerged in the water. The electrode provides a negative bias. A voltage source provides a positive bias to the sacrificial layer of chromium, anodically etching the sacrificial layer of chromium and freeing the portion of the structural layer.

Abstract: Systems and methods described herein are directed to an adjustable steering wheel. According to one aspect, a steering wheel includes a center post, a plurality of arc segments, a plurality of telescoping arms, and a plurality of modular segments. The plurality of arc segments have a fixed arc length relative to a center post axis defined by the center post. Each arm of the plurality of telescoping arms has a first end portion affixed to the center post and a second end portion non-removably affixed to an arc segment of the plurality of arc segments. The plurality of modular segments have adjustable arc lengths relative to the center post axis. Together the plurality of arc segments and the plurality of modular segments cooperate to define a circumference of the steering wheel that is orthogonal to the center post axis.

Abstract: A computer-implemented method designs a distributed heterogeneous computing and control system, including both an application and a hardware context and configuring the application in the hardware context. The method is implemented by design software instructions executing in a computer node, associated with an interactive display, to establish an interactive environment utilizing computer processes. The computer processes provide access in the interactive environment to a set of functional modules and a set of primitive modules. The computer processes receive the interactive environment a selection of desired ones of the functional modules and the primitive modules and order them in a manner to characterize the distributed computing and control system as a schematic of a set of devices. The computer processes parse the schematic to produce a set of sub-schematics that each correspond to a distinct device in a set of devices in the distributed computing and control system.

Abstract: A method and system involves vacuum sealing a semi-enclosure at room temperature without requiring mechanical actions within the vacuum chamber. The semi-enclosure has an inlet channel that extends inwardly into the vacuum chamber from an exterior opening (entryway) into the semi-enclosure. An uncured entryway vacuum sealant is provided at the entryway for the semi-enclosure. A vacuum is established in the vacuum chamber until the vacuum pressure reaches a desired vacuum pressure that causes the uncured entryway sealant to be provided to the entryway for the semi-enclosure. The uncured entryway vacuum sealant is cured under vacuum pressure in the semi-enclosure in the vacuum chamber.

Abstract: Disclosed herein are antigen-capturing nanoparticles. Specifically, the subject matter contained herein pertains to novel nanoparticles that can capture a multitude of tumor antigens that are released from tumor cells. Also, provided herein are methods for preparing the antigen-capturing nanoparticles and methods for the treatment of disease in a subject comprising administering the antigen-capturing nanoparticles.

Abstract: Methods for monitoring efficacy of cancer therapies, e.g., radiation therapy, using circulating tumor cell kinetics as a predictive marker are described.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: A lateral flow assay device that is defined by multiple loading zones, wherein a sample pad is located before and upstream from a conjugate pad and another sample pad is located after and downstream from the conjugate pad. This configuration allows for increased sensitivity for detecting an analyte in a specimen. The device may employ multiple collection pads or a single collection pad and the collection pads may be engaged with the sample pads in several manners, including but not limited to, pressing down on a cassette with collection pads onto a cassette with the test strips, or by sliding the collection pads along the cassette with the test strips and sample pads.

Abstract: A system includes a circular oscillator suspended by a flexible support structure to a support frame, a drive mechanism configured to induce the circular oscillator into a two-dimensional drive oscillation, where the drive oscillation is modified responsive to a sense oscillation of the circular oscillator caused by an angular rotation of the support frame and the circular oscillator, and a plurality of digital proximity switches disposed around a perimeter of the circular oscillator. During the modified drive oscillation a plurality of the digital proximity switches are configured to switch between an open state and a closed state and generate a time and position output to allow for a determination of each of a plurality of variable oscillation parameters for each oscillation of the modified drive oscillation.

Abstract: A ground fault detection system based on capacitive sensing suitable for use in detecting a ground fault condition in electronic equipment (such as a PCBA) with a circuit ground electrically isolated from an isolation ground (such as chassis ground). The capacitive sensing system includes a capacitive sensor capacitively coupled to the system isolation ground, and a capacitance/data converter that captures sensor capacitance measurements for conversion to sensor data representative of a ground short. In one embodiment, the capacitive sensor includes a sensor electrode capacitively coupled to the system isolation ground by one of projected capacitance and a floating capacitor (such as 33 pf), and the CDC unit further includes sensor excitation circuitry configured to drive the sensor electrode, such that a sensor capacitance (projected or floating capacitance) is representative of an electrical condition of the system isolation ground.

Abstract: A device includes two electrically isolated metalized posts attached in close proximity to each other on a bendable substrate. When the bendable substrate bends concavely with respect to the surface onto which the posts are mounted, the distance between the tops of the two posts decreases. At a fixed bending curvature, the two posts will meet and complete an electrical circuit. The posts comprise a flexible material so that the meeting of the posts has minimal effect on the spring constant or damping coefficient of the harmonic oscillation.

Abstract: A method of treating neoplasia in a subject in need of treatment is provided by administering to the subject an amount of a prodrug of mitomycin C that yields a therapeutically effective amount of mitomycin C, in combination with radiation therapy. In one embodiment, the prodrug of mitomycin C is a liposomal-prodrug of mitomycin C. Together, the prodrug of mitomycin C and radiation therapy provide a synergistic antineoplastic effect.

Abstract: A device includes two electrically isolated metalized posts attached in close proximity to each other on a bendable substrate. When the bendable substrate bends concavely with respect to the surface onto which the posts are mounted, the distance between the tops of the two posts decreases. At a fixed bending curvature, the two posts will meet and complete an electrical circuit. The posts comprise a flexible material so that the meeting of the posts has minimal effect on the spring constant or damping coefficient of the harmonic oscillation.

Abstract: The present invention provides new compositions containing nearly monodisperse colloidal core/shell semiconductor nanocrystals with high photoluminescence quantum yields (PL QY), as well as other complex structured semiconductor nanocrystals. This invention also provides new synthetic methods for preparing these nanocrystals, and new devices comprising these compositions. In addition to core/shell semiconductor nanocrystals, this patent application also provides complex semiconductor nanostructures, quantum shells, quantum wells, doped nanocrystals, and other multiple-shelled semiconductor nanocrystals.

Abstract: A method and system involves vacuum sealing a semi-enclosure at room temperature without requiring mechanical actions within the vacuum chamber. The semi-enclosure has an inlet channel that extends inwardly into the vacuum chamber from an exterior opening (entryway) into the semi-enclosure. An uncured entryway vacuum sealant is provided at the entryway for the semi-enclosure. A vacuum is established in the vacuum chamber until the vacuum pressure reaches a desired vacuum pressure that causes the uncured entryway sealant to be provided to the entryway for the semi-enclosure. The uncured entryway vacuum sealant is cured under vacuum pressure in the semi-enclosure in the vacuum chamber.

Abstract: A lateral flow assay device that is defined by multiple loading zones, wherein a sample pad is located before and upstream from a conjugate pad and another sample pad is located after and downstream from the conjugate pad. This configuration allows for increased sensitivity for detecting an analyte in a specimen. The device may employ multiple collection pads or a single collection pad and the collection pads may be engaged with the sample pads in several manners, including but not limited to, pressing down on a cassette with collection pads onto a cassette with the test strips, or by sliding the collection pads along the cassette with the test strips and sample pads.