Abstract: The present disclosure provides an antibody (or antigen binding protein) comprising at least one, preferably two, antigen binding domains that binds to human IL-6 receptor, wherein said antibody inhibits IL-6 trans signalling through the human soluble IL-6 receptor while maintaining IL-6 classical signalling through the human membrane-bound IL-6 receptor, and wherein said antibody can bind to human soluble IL-6 receptor and human membrane-bound IL-6 receptor. Compositions comprising said antibodies or antigen binding proteins are also provided, together with encoding nucleic acid molecules and expression vectors.

Abstract: A mobile system for a robotic drive includes a tray configured to support the robotic drive, a cart configured to support the tray in a substantially horizontal position, one or more wheels coupled to the cart, and an assembly coupled to the cart. The assembly is configured to allow the tray to move from the substantially horizontal position to a second position which is less horizontal than the substantially horizontal position, and is configured to resist movement of the tray from the substantially horizontal position to the second position.

Abstract: An apparatus includes a drive module having a drive module base component and a load-sensed component. An elongated medical device (EMD) is removably coupled to an isolated component. The isolated component is isolated from an external load other than an actual load acting on the EMD. The isolated component is removably coupled to the load-sensed component. A load sensor is secured to the drive module base component and the load-sensed component sensing the actual load acting on the EMD.

Abstract: Systems and methods are disclosed herein for synchronous music streaming. The systems and methods can determine that a first user computing device is connected to a first music streaming service and access data associated with the first music streaming service. The systems and methods can identify a playback position of a song playing in the first music streaming service based on the data and synchronize the song to the atomic clock based on the playback position. The systems and methods can determine that a second user computing device is connected to a second music streaming service and start the song in the second music streaming service at the playback position of the song based on the synchronization. The song can thereby play in sync via both music streaming services on both user computing device, regardless of the music streaming service provider and user computing device operating system.

Abstract: A modular bioprocessing system having a plurality of bioprocessing modules, each independently receiving a biological handling container and performing one or more unit operations on the biological handling container and/or its contents; and a robot that moves the biological handling container between each of the bioprocessing modules.

Abstract: The present invention provides a semiconductor structure comprising: a silicon substrate in [100] orientation; a scandium oxide layer over the substrate, in [111] orientation; and a scandium-rare earth-oxide layer over the scandium oxide layer. The scandium-rare earth-oxide layer can have a graded composition to transition lattice constant to match to a subsequent layer, such as an indium nitride layer having very high electron drift velocity. InN over Si (100) offers transistors, photonics and passive electronics that operate in the terahertz frequency range.

Abstract: A system for controlling a robotic drive including a plurality of cassettes, each of the plurality of cassettes to support and move a respective elongated medical device. The system includes a housing, one or more first controls integrated with the housing and manipulable to select at least two of the one or more elongated medical devices, and a second control integrated with the housing and manipulable to input, while the at least two of the one or more elongated medical devices are selected, an instruction to rotate the at least two selected elongated medical devices. In response to the instruction, the system is to transmit a first signal to the robotic drive to rotate a first one of the at least two selected elongated medical devices, and not transmit a second signal to the robotic drive to rotate a second one of the at least two selected elongated medical devices.

Abstract: A controller includes at least one processor and memory coupled to the at least one processor. The memory stores computer-executable instructions. The at least one processor is configured to execute the computer-executable instructions to cause the controller to determine a clinical driving scenario associated with a percutaneous device, and set driving characteristics associated with the percutaneous device based on the clinical driving scenario and information included in a driving profile, wherein the information included in the driving profile includes information associating particular clinical driving scenarios with particular driving characteristics.

Abstract: An optical interference filter includes one or more sets of layers. Each set of layers includes a first layer that includes at least aluminum and nitrogen (e.g., an aluminum nitride (AlN) material), a second layer that includes at least silicon and oxygen (e.g., a silicon dioxide (SiO2) material), and a third layer that includes at least hydrogen and silicon (e.g., a hydrogenated silicon (Si:H) material). The second layer is disposed between the first layer and the third layer.

Abstract: A system for a robotic drive including a plurality of device modules configured to control motion of one or more elongated medical devices includes display of a respective icon representing each of the plurality of device modules, a position of each icon corresponding to a physical position of a device module represented by the icon, detection of a change in the physical position of one of the plurality of device modules to a new physical position, and, in response to detection of the change, changing of the position of the icon representing the one of the plurality of device modules to correspond to the new physical position.

Abstract: A robotic drive system for driving one or more elongated medical devices, the robotic drive can include a linear member and at least four device modules coupled to the linear member. Each device module may be independently controllable. The plurality of device modules may be switched between a first configuration where each device module is populated with an elongated medical device and a second configuration where a subset of the at least four device modules is populated with an elongated medical device.

Abstract: A system for controlling a robotic drive configured to move one or more elongated medical devices. The system may include a housing comprising a first surface and a second surface not co-planar with the first surface, a first control integrated with the first surface and manipulable by a first digit of a first hand of a user to select one of the one or more elongated medical devices, and a second control integrated with the second surface and manipulable by a second digit of the first hand of the user to instruct the robotic drive to move the selected elongated medical device in a first degree of freedom, wherein the first control and the second control are simultaneously manipulable by the first digit and the second digit.

Abstract: A robotic drive system for driving one or more elongated medical devices, the robotic drive can include a linear member and at least four device modules coupled to the linear member. Each device module may be independently controllable. The plurality of device modules may be switched between a first configuration where each device module is populated with an elongated medical device and a second configuration where a subset of the at least four device modules is populated with an elongated medical device.

Abstract: A system for controlling a catheter-based procedure system that includes a robotic drive configured to control rotational motion and axial motion of one or more elongated medical devices may include a body, a first control coupled to the body, and a second control coupled to the body. First control is configured to instruct the robotic drive to axially move one of the one or more elongated medical devices in response to manipulation of the first control by a user, and the second control is configured to instruct the robotic drive to rotate one of the one or more elongated medical devices in response to manipulation of the second control by the user, wherein the first control and the second control are positioned on the body so the first control and the second control can be simultaneously manipulated by a first digit and a second digit on a hand of the user.

Abstract: An optical interference filter includes one or more sets of layers. Each set of layers includes a first layer that includes at least aluminum and nitrogen (e.g., an aluminum nitride (AlN) material), a second layer that includes at least silicon and oxygen (e.g., a silicon dioxide (SiO2) material), and a third layer that includes at least hydrogen and silicon (e.g., a hydrogenated silicon (Si:H) material). The second layer is disposed between the first layer and the third layer.

Abstract: A layered structure including a substrate in [100] crystal orientation, a crystalline bixbyite oxide layer in [111] orientation, and a metal-containing layer crystallographically matched to the crystalline bixbyite oxide layer. Also a method of fabricating a layered structure comprising steps to: epitaxially deposit a crystalline bixbyite oxide in [111] orientation on a substrate in [100] crystal orientation; and deposit a metal-containing layer on the crystalline bixbyite oxide layer.

Abstract: A sputtering system may include a substrate. The sputtering system may include at least one target. The at least one target may include at least one coating material to coat at least one layer onto the substrate. The at least one coating material may be sputtered onto the substrate in a presence of an inert gas. The inert gas may include argon gas and helium gas.

Abstract: A mobile system for a robotic drive includes a tray configured to support the robotic drive, a cart configured to support the tray in a substantially horizontal position, one or more wheels coupled to the cart, and an assembly coupled to the cart. The assembly is configured to allow the tray to move from the substantially horizontal position to a second position which is less horizontal than the substantially horizontal position, and is configured to resist movement of the tray from the substantially horizontal position to the second position.

Abstract: A cassette for use in a robotic drive of a catheter-based procedure system includes a housing configured to support a hemostasis valve having a base and a side port. The housing has a longitudinal device axis associated with an elongated medical device. The cassette also includes a first tube connection point positioned on the housing and above the longitudinal device axis. The first tube connection point is configured to receive a first tube. The cassette further includes a second tube connection point positioned proximate to a top edge of the housing and above the first tube connection point and the longitudinal device axis. The second tube connection point is configured to receive a second tube.

Abstract: A user interface for managing a robotic drive to control one or more elongated medical devices (EMDs) supported by respective two or more cassettes of the robotic drive includes a first area to indicate a first two or more cassettes of the robotic drive which are selected to simultaneously manipulate a first two or more EMDs supported thereby in response to actuation of a first control, and a second area to indicate a second one or more cassettes of the robotic drive which are selected to simultaneously manipulate a second one or more EMDs supported thereby in response to actuation of a second control.