Abstract: The present disclosure provides, among other things, methods of drying porcine thyroid gland material and manufacturing DTE comprising vacuum drying porcine thyroid gland material in a way such that the temperature of the porcine thyroid gland material is maintained above a threshold temperature. Since applying vacuum, or reducing pressure, has a cooling effect on the porcine thyroid gland material, maintaining the porcine thyroid gland material above a threshold temperature can be achieved by gradually reducing pressure while simultaneously increasing the heat applied to the porcine thyroid gland material during the period of gradual pressure change. Such methods are advantageous in reducing bioburden (killing and impeding the growth of microorganisms) while maintaining therapeutic levels of thyroid hormones, as compared to certain methods of drying porcine thyroid gland material and/or manufacturing DTE known in the art.

Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.

Abstract: Techniques are disclosed relate to systems, methods, and non-transitory computer readable media for implementing a browser extension for cyber threat intelligence and response. One system to perform operations comprising: scanning, in a sandbox of a browser by a browser extension, at least part of a web page to produce a set of items of interests; transmitting the set of items of interests to a cloud-based enrichment and analysis of cybersecurity threat intelligence system to request information on the set of items; receiving a response from the cloud-based enrichment and analysis of cybersecurity threat intelligence system, the response including a scan result based on the transmitted set of items of interests, and the scan result including at least one of an indicator of compromise of the at least scanned part of the web page; and displaying the scan results including the at least one of an indicator of compromise.

Abstract: A method of modeling that allows for kinetic parameters to be extracted from DCE-MRIs performed with the temporal resolutions commonly used in the clinical setting is described herein. The kinetic parameters can be combined with analytic models of cancers to create predictors of disease recurrence.

Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.

Abstract: Apparatuses, methods, and systems for automated testing and selection of multiple templates of a form. One method includes receiving, by a server, a first input text message from a user, displaying, by the server, the first input text message to an agent, displaying, by the server, a configurable menu of responses to the first input text message to the agent, receiving, by the server, a selection of one of the configurable menu of responses from the agent, facilitating, by the server, sending of the selected of one of the configurable menu of responses to the user, and associating and recording the selected one of the configurable menu of responses with the first input text message.

Abstract: Apparatuses, methods, and systems for implicitly annotating textual data in conversational messaging are disclosed. One method includes receiving, by a server, a first input text message from a user (customer), displaying, by the server, the first input text message to an agent (merchant), displaying, by the server, a configurable menu of responses to the first input text message to the agent (merchant), receiving, by the server, a selection of one of the configurable menu of responses from the agent (merchant), facilitating, by the server, sending of the selected of one of the configurable menu of responses to the user (customer); and associating and recording the selected one of the configurable menu of responses with the first input text message.

Abstract: In some examples, one or more processors configured by executable instructions may receive an audio signal and data to embed in the audio signal. For example, the data may be received dynamically from one or more data sources. The one or more processors may embed the received data in real time into the audio signal as embedded data based at least in part on controlling a phase angle of a selected frequency component of the audio signal. For instance, the embedded data may include at least one of text, a bar code, a quick response code, an image, a uniform resource locator (URL), or multimedia content. Additionally, the one or more processors may send the audio signal with the embedded data over a network to a plurality of electronic devices that include respective decoders for extracting the embedded data from the audio signal.

Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.

Abstract: A cassette for a drug delivery device is described that includes a sleeve, a syringe having a barrel disposed in the sleeve, and a plunger-stopper slidably disposed within the barrel. The cassette further includes a spacer that is configured to be coupled to the sleeve. The cassette can form a part of an apparatus for injection of a therapeutic product along with a drug delivery device.

Abstract: An electronic material sensor for a container, such as a dispenser for paper or liquid materials, or a waste receptacle, in a facility such as a restroom. The material sensor may be adapted to fit inside an existing material dispenser. The material sensor provides wireless data transmission of the level of liquid or paper material in the container. A traffic sensor senses presence of people in the facility. An electronic beacon assigned to a user, such as a cleaning staff, tracks location of the user in the facility. In a system employing one or more sensors, including material sensors, traffic sensors, and beacons, the sensors send real-time data to a base station running a software application, to give details about levels of the materials and facility usage, and the location of cleaning staff.

Abstract: Apparatuses, methods, and systems for implicitly associating user intents to agent selected responses. One method includes receiving, by a server, a first input text message from a user, displaying, by the server, the first input text message to an agent, receiving, by the server, a first response to the first input text message from the agent, computing a first intent with the first input text message, prompting, by the server, the agent whether to associate the first response with the computed first intent of the first input text message, and recording the first response with the computed first intent of the first input message when the agent indicates an association between the first response with the computed first intent of the first input message.

Abstract: Apparatuses, methods, and systems for implicitly annotating textual data in conversational messaging are disclosed. One method includes receiving, by a server, a first input text message from a user (customer), displaying, by the server, the first input text message to an agent (merchant), displaying, by the server, a configurable menu of responses to the first input text message to the agent (merchant), receiving, by the server, a selection of one of the configurable menu of responses from the agent (merchant), facilitating, by the server, sending of the selected of one of the configurable menu of responses to the user (customer); and associating and recording the selected one of the configurable menu of responses with the first input text message.

Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.

Abstract: A method of constructing and handling a request for a desired data file relating to a broadcast segment of a broadcast signal is described. The method comprises receiving an information signal at a receiving device. The information signal comprises at least a data element, and the data element relates to a segment of the broadcast signal. The method also comprises presenting the data element to a user interface of the receiving device, obtaining a user selection of the data element from the user interface, and constructing and transmitting a request for the desired data file relating to the selected data element, the request including an identifier relating to the desired data file.

Abstract: This disclosure describes a drug delivery device with communication functionality for purposes of transferring information to a user device, such as a smartphone, while maintaining power-efficient operation. The drug delivery device comprises a controller configured to, while operating in the active mode, use one or more sensors to detect that the injection mechanism has performed an injection. The controller is also configured to generate in memory a data entry indicative of the injection and/or a state of the drug delivery device, and switch into the low-power mode subsequent to or contemporaneous with detecting that the injection mechanism has performed the injection. The drug delivery device also comprises a wireless communication module powered by the power source and configured to establish a wireless connection with and transfer a message to a user device while the controller is operating in the low-power mode.

Abstract: An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection can cause the autoinjector to stop an extrusion process.

Abstract: An electronic material sensor for a container, such as a dispenser for paper or liquid materials, or a waste receptacle, in a facility such as a restroom. The material sensor may be adapted to fit inside an existing material dispenser. The material sensor provides wireless data transmission of the level of liquid or paper material in the container. A traffic sensor senses presence of people in the facility. An electronic beacon assigned to a user, such as a cleaning staff, tracks location of the user in the facility. In a system employing one or more sensors, including material sensors, traffic sensors, and beacons, the sensors send real-time data to a base station running a software application, to give details about levels of the materials and facility usage, and the location of cleaning staff.

Abstract: A cassette for a drug delivery device is described that includes a sleeve, a syringe having a barrel disposed in the sleeve, and a plunger-stopper slidably disposed within the barrel. An end cap is adapted to couple to the sleeve to secure the syringe in the sleeve. The cassette further includes a spacer that is sized to be slidably moved within the barrel and the spacer is disposed distal to the plunger-stopper to be engaged by a plunger rod to slide within the barrel and engage the plunger-stopper. In some forms, the spacer can be coupled to the end cap.