Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.

Abstract: Apparatuses, methods, and systems for automated testing and selection of multiple templates of a form. One method includes receiving, by a server, a first input text message from a user, displaying, by the server, the first input text message to an agent, displaying, by the server, a configurable menu of responses to the first input text message to the agent, receiving, by the server, a selection of one of the configurable menu of responses from the agent, facilitating, by the server, sending of the selected of one of the configurable menu of responses to the user, and associating and recording the selected one of the configurable menu of responses with the first input text message.

Abstract: Apparatuses, methods, and systems for implicitly annotating textual data in conversational messaging are disclosed. One method includes receiving, by a server, a first input text message from a user (customer), displaying, by the server, the first input text message to an agent (merchant), displaying, by the server, a configurable menu of responses to the first input text message to the agent (merchant), receiving, by the server, a selection of one of the configurable menu of responses from the agent (merchant), facilitating, by the server, sending of the selected of one of the configurable menu of responses to the user (customer); and associating and recording the selected one of the configurable menu of responses with the first input text message.

Abstract: In some examples, one or more processors configured by executable instructions may receive an audio signal and data to embed in the audio signal. For example, the data may be received dynamically from one or more data sources. The one or more processors may embed the received data in real time into the audio signal as embedded data based at least in part on controlling a phase angle of a selected frequency component of the audio signal. For instance, the embedded data may include at least one of text, a bar code, a quick response code, an image, a uniform resource locator (URL), or multimedia content. Additionally, the one or more processors may send the audio signal with the embedded data over a network to a plurality of electronic devices that include respective decoders for extracting the embedded data from the audio signal.

Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.

Abstract: A cassette for a drug delivery device is described that includes a sleeve, a syringe having a barrel disposed in the sleeve, and a plunger-stopper slidably disposed within the barrel. The cassette further includes a spacer that is configured to be coupled to the sleeve. The cassette can form a part of an apparatus for injection of a therapeutic product along with a drug delivery device.

Abstract: An electronic material sensor for a container, such as a dispenser for paper or liquid materials, or a waste receptacle, in a facility such as a restroom. The material sensor may be adapted to fit inside an existing material dispenser. The material sensor provides wireless data transmission of the level of liquid or paper material in the container. A traffic sensor senses presence of people in the facility. An electronic beacon assigned to a user, such as a cleaning staff, tracks location of the user in the facility. In a system employing one or more sensors, including material sensors, traffic sensors, and beacons, the sensors send real-time data to a base station running a software application, to give details about levels of the materials and facility usage, and the location of cleaning staff.

Abstract: Apparatuses, methods, and systems for implicitly associating user intents to agent selected responses. One method includes receiving, by a server, a first input text message from a user, displaying, by the server, the first input text message to an agent, receiving, by the server, a first response to the first input text message from the agent, computing a first intent with the first input text message, prompting, by the server, the agent whether to associate the first response with the computed first intent of the first input text message, and recording the first response with the computed first intent of the first input message when the agent indicates an association between the first response with the computed first intent of the first input message.

Abstract: Apparatuses, methods, and systems for implicitly annotating textual data in conversational messaging are disclosed. One method includes receiving, by a server, a first input text message from a user (customer), displaying, by the server, the first input text message to an agent (merchant), displaying, by the server, a configurable menu of responses to the first input text message to the agent (merchant), receiving, by the server, a selection of one of the configurable menu of responses from the agent (merchant), facilitating, by the server, sending of the selected of one of the configurable menu of responses to the user (customer); and associating and recording the selected one of the configurable menu of responses with the first input text message.

Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.

Abstract: A method of constructing and handling a request for a desired data file relating to a broadcast segment of a broadcast signal is described. The method comprises receiving an information signal at a receiving device. The information signal comprises at least a data element, and the data element relates to a segment of the broadcast signal. The method also comprises presenting the data element to a user interface of the receiving device, obtaining a user selection of the data element from the user interface, and constructing and transmitting a request for the desired data file relating to the selected data element, the request including an identifier relating to the desired data file.

Abstract: This disclosure describes a drug delivery device with communication functionality for purposes of transferring information to a user device, such as a smartphone, while maintaining power-efficient operation. The drug delivery device comprises a controller configured to, while operating in the active mode, use one or more sensors to detect that the injection mechanism has performed an injection. The controller is also configured to generate in memory a data entry indicative of the injection and/or a state of the drug delivery device, and switch into the low-power mode subsequent to or contemporaneous with detecting that the injection mechanism has performed the injection. The drug delivery device also comprises a wireless communication module powered by the power source and configured to establish a wireless connection with and transfer a message to a user device while the controller is operating in the low-power mode.

Abstract: An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection can cause the autoinjector to stop an extrusion process.

Abstract: An electronic material sensor for a container, such as a dispenser for paper or liquid materials, or a waste receptacle, in a facility such as a restroom. The material sensor may be adapted to fit inside an existing material dispenser. The material sensor provides wireless data transmission of the level of liquid or paper material in the container. A traffic sensor senses presence of people in the facility. An electronic beacon assigned to a user, such as a cleaning staff, tracks location of the user in the facility. In a system employing one or more sensors, including material sensors, traffic sensors, and beacons, the sensors send real-time data to a base station running a software application, to give details about levels of the materials and facility usage, and the location of cleaning staff.

Abstract: A cassette for a drug delivery device is described that includes a sleeve, a syringe having a barrel disposed in the sleeve, and a plunger-stopper slidably disposed within the barrel. An end cap is adapted to couple to the sleeve to secure the syringe in the sleeve. The cassette further includes a spacer that is sized to be slidably moved within the barrel and the spacer is disposed distal to the plunger-stopper to be engaged by a plunger rod to slide within the barrel and engage the plunger-stopper. In some forms, the spacer can be coupled to the end cap.

Abstract: An electronic material sensor for a container, such as a dispenser for paper or liquid materials, or a waste receptacle, in a facility such as a restroom. The material sensor may be adapted to fit inside an existing material dispenser. The material sensor provides wireless data transmission of the level of liquid or paper material in the container. A traffic sensor senses presence of people in the facility. An electronic beacon assigned to a user, such as a cleaning staff, tracks location of the user in the facility. In a system employing one or more sensors, including material sensors, traffic sensors, and beacons, the sensors send real-time data to a base station running a software application, to give details about levels of the materials and facility usage, and the location of cleaning staff.

Abstract: In some examples, one or more processors configured by executable instructions may receive an audio signal and data to embed in the audio signal. For example, the data may be received dynamically from one or more data sources. The one or more processors may embed the received data in real time into the audio signal as embedded data based at least in part on controlling a phase angle of a selected frequency component of the audio signal. For instance, the embedded data may include at least one of text, a bar code, a quick response code, an image, a uniform resource locator (URL), or multimedia content. Additionally, the one or more processors may send the audio signal with the embedded data over a network to a plurality of electronic devices that include respective decoders for extracting the embedded data from the audio signal.

Abstract: An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection causes the autoinjector to stop an extrusion process.

Abstract: In some examples, an audio signal is received and divided into a plurality of frames. Frequency domain data of the audio signal may be generated for an individual frame of the plurality of frames. For example, the frequency domain data may include a plurality of frequency waveform components. Data may be embedded into a selected frequency waveform component having a lower frequency, selected from the frequency domain data of the individual frames, by controlling a phase value of the frequency waveform component to represent a selected bit of the data. For instance, a first range of the phase value may represent a first type of bit and a second range of the phase value may represent a second type of bit.

Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a cassette, a door coupled to the housing, a drive mechanism, and a latching assembly. The cassette is removably disposed within the inner volume and is adapted to contain a drug to be administered to a user. The door at least partially encloses the inner volume of the housing and includes a first end defining a latching portion. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the drug out the cassette. The latching assembly is coupled to the drive mechanism and includes a first end and a second end. Upon actuating the drive mechanism, the drive mechanism causes the latching assembly to engage the latching portion of the door to secure the door to the housing.