Abstract: In some examples, one or more processors configured by executable instructions may receive an audio signal and data to embed in the audio signal. For example, the data may be received dynamically from one or more data sources. The one or more processors may embed the received data in real time into the audio signal as embedded data based at least in part on controlling a phase angle of a selected frequency component of the audio signal. For instance, the embedded data may include at least one of text, a bar code, a quick response code, an image, a uniform resource locator (URL), or multimedia content. Additionally, the one or more processors may send the audio signal with the embedded data over a network to a plurality of electronic devices that include respective decoders for extracting the embedded data from the audio signal.

Abstract: An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection causes the autoinjector to stop an extrusion process.

Abstract: In some examples, an audio signal is received and divided into a plurality of frames. Frequency domain data of the audio signal may be generated for an individual frame of the plurality of frames. For example, the frequency domain data may include a plurality of frequency waveform components. Data may be embedded into a selected frequency waveform component having a lower frequency, selected from the frequency domain data of the individual frames, by controlling a phase value of the frequency waveform component to represent a selected bit of the data. For instance, a first range of the phase value may represent a first type of bit and a second range of the phase value may represent a second type of bit.

Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a cassette, a door coupled to the housing, a drive mechanism, and a latching assembly. The cassette is removably disposed within the inner volume and is adapted to contain a drug to be administered to a user. The door at least partially encloses the inner volume of the housing and includes a first end defining a latching portion. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the drug out the cassette. The latching assembly is coupled to the drive mechanism and includes a first end and a second end. Upon actuating the drive mechanism, the drive mechanism causes the latching assembly to engage the latching portion of the door to secure the door to the housing.

Abstract: A cable tie is provided with a wedge disposed within a passage extending through a head. The wedge is compressed within the passage when tension is applied to the strap. As a result, the wedge compresses the strap against an inner surface of the passage to restrain the strap.

Abstract: Methods, devices, and computer programs are presented for consolidating overlapping data provided by multiple sources. One method includes operations for associating a plurality of devices to a user, each device operable to capture data associated with the user, and for receiving, from the plurality of devices, captured data about a first activity associated with a first period of time. Additionally, the method includes operations for detecting that the received captured data from two or more devices provide overlapping information about the first activity, and for evaluating one or more rules for consolidating the overlapping information to produce consolidated data. The consolidated data provides a unified view of the first activity during the first period of time. The consolidated data is stored in permanent storage and made available for presentation to the user.

Abstract: In some examples, an audio signal is received and divided into a plurality of frames. Frequency domain data of the audio signal may be generated for an individual frame of the plurality of frames. For example, the frequency domain data may include a plurality of frequency waveform components. Data may be embedded into a selected frequency waveform component having a lower frequency, selected from the frequency domain data of the individual frames, by controlling a phase value of the frequency waveform component to represent a selected bit of the data. For instance, a first range of the phase value may represent a first type of bit and a second range of the phase value may represent a second type of bit.

Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.

Abstract: An electronic material sensor for a container, such as a dispenser for paper or liquid materials, or a waste receptacle, in a facility such as a restroom. The material sensor may be adapted to fit inside an existing material dispenser. The material sensor provides wireless data transmission of the level of liquid or paper material in the container. A traffic sensor senses presence of people in the facility. An electronic beacon assigned to a user, such as a cleaning staff, tracks location of the user in the facility. In a system employing one or more sensors, including material sensors, traffic sensors, and beacons, the sensors send real-time data to a base station running a software application, to give details about levels of the materials and facility usage, and the location of cleaning staff.

Abstract: In some examples, an audio signal is received and divided into a plurality of frames. Frequency domain data of the audio signal may be generated for an individual frame of the plurality of frames. For example, the frequency domain data may include a plurality of sinusoidal components. Data may be embedded into a selected sinusoidal component selected from the frequency domain data of the individual frame by controlling a phase angle of the selected sinusoidal component to represent a selected bit of the data. For instance, a first range of the phase angle may represent a first type of bit and a second range of the phase angle may represent a second type of bit.

Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.

Abstract: In some examples, an audio signal is received and divided into a plurality of frames. Frequency domain data of the audio signal may be generated for an individual frame of the plurality of frames. For example, the frequency domain data may include a plurality of sinusoidal components. Data may be embedded into a selected sinusoidal component selected from the frequency domain data of the individual frame by controlling a phase angle of the selected sinusoidal component to represent a selected bit of the data. For instance, a first range of the phase angle may represent a first type of bit and a second range of the phase angle may represent a second type of bit.

Abstract: The disclosure provides BMDs that have multiple device modes depending on operational conditions of the devices, e.g., motion intensity, device placement, and/or activity type. The device modes are associated with various data processing algorithms. In some embodiments, the BMD is implemented as a wrist-worn or arm-worn device. In some embodiments, methods for tracking physiological metrics using the BMDs are provided. In some embodiments, the process or the BMD applies a time domain analysis on data provided by a sensor of the BMD when the data has a high signal (e.g., high signal-to-noise ratio), and applies a frequency domain analysis on the data when the data has a low signal, which contributes to improved accuracy and speed of biometric data.

Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.

Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a cassette, a door coupled to the housing, a drive mechanism, and a latching assembly. The cassette is removably disposed within the inner volume and is adapted to contain a drug to be administered to a user. The door at least partially encloses the inner volume of the housing and includes a first end defining a latching portion. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the drug out the cassette. The latching assembly is coupled to the drive mechanism and includes a first end and a second end. Upon actuating the drive mechanism, the drive mechanism causes the latching assembly to engage the latching portion of the door to secure the door to the housing.

Abstract: An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection causes the autoinjector to stop an extrusion process.

Abstract: In some examples, an interactive audio system includes a receiver for receiving a broadcasted radio frequency (RF) carrier signal. The system may demodulate a portion of the RF carrier signal to receive a demodulated output signal. For example, the demodulated output signal may include a demodulated audio program having embedded data contained within the demodulated audio signal. The system may extract the embedded data from the demodulated audio program. The system may present information related to the extracted embedded data on a display and/or may send at least a portion of the extracted embedded data to another device.

Abstract: An activity monitoring device, methods and computer readable media are provided. The activity monitoring device includes a housing configured for attachment to a body part of a user and a display screen attached to the housing. Further included is a first sensor disposed in the housing for capturing motion of the activity monitoring device when attached to the body part of the user and a second sensor disposed in the housing for sampling a heart rate of the user. Memory is disposed in the housing for storing the motion captured by the first sensor and the heart rate sampled by the second sensor. A processor is disposed in the housing and is configured to determine a physical state of the user during a period of time. For motion that is below a threshold the processor identifies the physical state to be a sedentary state and for motion that is at or above the threshold the processor identifies the physical state to be an active state.

Abstract: The disclosure provides BMDs that have multiple device modes depending on operational conditions of the devices, e.g., motion intensity, device placement, and/or activity type, the device modes are associated with various data processing algorithms. In some embodiments, the BMD is implemented as a wrist-worn or arm-worn device. In some embodiments, methods for tracking physiological metrics using the BMDs are provided. In some embodiments, the process and the BMD applies a time domain analysis on data provided by a sensor of the BMD when the data has a high signal (e.g., high signal-to-noise ratio), and applies a frequency domain analysis on the data when the data has a low signal, which contributes to improved accuracy and speed of biometric data.

Abstract: The disclosure provides BMDs that have multiple device modes depending on operational conditions of the devices, e.g., motion intensity, device placement, and/or activity type, the device modes are associated with various data processing algorithms. In some embodiments, the BMD is implemented as a wrist-worn or arm-worn device. In some embodiments, methods for tracking physiological metrics using the BMDs are provided. In some embodiments, the process and the BMD applies a time domain analysis on data provided by a sensor of the BMD when the data has a high signal (e.g., high signal-to-noise ratio), and applies a frequency domain analysis on the data when the data has a low signal, which contributes to improved accuracy and speed of biometric data.