Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The presently disclosed subject matter relates to isolated compositions and methods for treating and/or preventing sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). In some embodiments, the presently disclosed subject matter relates to endothelial progenitor cell-derived exosomes to treat and/or prevent sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). The endothelial progenitor cell-derived exosomes can be modified to overexpress one or more miRNAs.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: The invention relates to a detection arrangement, a detection system comprising said arrangement, and a method of processing data from said arrangement. The detector arrangement disclosed comprises at least one array of detectors, wherein the detectors are configured to detect photons emitted from an object as a result of positron annihilation due to irradiation of the object with photons of a predetermined energy. Each detector in the array is linked to or associated with one or more other detector in the array to define a region of interest (RoI). The detector arrangement comprises or is communicatively coupled to a coincidence trigger unit which is configured to register or determine a coincidence in response to receiving detection signals from two different detectors forming part of the same RoI and indicating detection of substantially back-to-back co-linear and co-incident photons in the RoI.

Abstract: According to one aspect of the disclosure, packaging for a sterile syringe having a nominal size of less than 1 mL may include a flexible tray having a cavity for containing the syringe. The cavity may include an opening, one or more sidewalls, and a base. A lip may surround the opening, may extend radially outward from the cavity, and may define a periphery of the tray. A removable cover may have a periphery that is adhered to the lip, and the removable cover may be permeable to a gaseous sterilant, including one or more of vaporized hydrogen peroxide or ethylene oxide. A projection may be associated with the base of the cavity and may extend away from the base of the cavity in a direction opposite to the opening of the cavity.

Abstract: According to one aspect of the disclosure, packaging for a sterile syringe having a nominal size of less than 1 mL may include a flexible tray having a cavity for containing the syringe. The cavity may include an opening, one or more sidewalls, and a base. A lip may surround the opening, may extend radially outward from the cavity, and may define a periphery of the tray. A removable cover may have a periphery that is adhered to the lip, and the removable cover may be permeable to a gaseous sterilant, including one or more of vaporized hydrogen peroxide or ethylene oxide. A projection may be associated with the base of the cavity and may extend away from the base of the cavity in a direction opposite to the opening of the cavity.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: The present application describes an integrated module. The integrated module includes a microcontroller, an inertial measurement unit (IMU), a low-power accelerometer, and an environmental sensor. A noise target between the IMU and low-power accelerometer is less than a noise target be the IMU and microcontroller. The present application also describes a method of using an integrated module.

Abstract: A packaging comprising a tray having an opening, a cavity including at least three cavity portions, a plurality of sidewalls, and a base; and a sterile syringe contained within the cavity, wherein the sterile syringe is pre-filled with a medicament or other fluid; wherein a first cavity portion comprises a plunger rod of the sterile syringe, a second cavity portion comprises a barrel of the sterile syringe, and a third cavity portion comprises a needle attachment portion of the sterile syringe, wherein the at least three cavity portions are connected to one another by intermediate narrowed portions, and wherein each of the narrowed portions includes a first sidewall, a second sidewall, a base, and a plurality of geometric features projecting into the narrowed portions to position the sterile syringe away from the plurality of sidewalls.

Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: A stator angle is determined to correct a value measured by a wheel force transducer. A mounting bracket is rigidly attached to a vehicle and supports a housing within which a rotary encoder is mounted. A stator rod retainer is aligned with a rotational axis of the rotary encoder and has a through-bore extending perpendicular to the rotational axis. The stator rod retainer rotates relative to a stationary portion of the rotary encoder using at least one bearing, and the stator rod retainer supports a first end of a stator rod for substantially free movement through the through-bore. A controller determines, when the second end of the stator rod is fixedly attached to an encoder stator attached to a wheel, a stator angle of the stator rod used for adjusting at least one value associated with the wheel that is measured using the encoder stator.

Abstract: The present application describes a machine learning method for detecting tamper. The method includes a step of training a model using one or more values obtained from one or more different sensors on an integrated module. The one or more values act as training data with respect to one or more of light, acceleration, magnetic field, rotation, temperature, pressure, humidity, and audio. The method also includes a step of predicting, via the trained model, tampering of the of the integrated module. The present application also describes a system for detecting tamper.

Abstract: Methods of manufacture, devices, and systems are described for a nasal swab. The swab includes an elongated body having a distal end. The swab includes a collection layer proximate to the distal end of the elongated body. The collection layer has a first geometric layout and configured to collect samples in the nasal passageway. The swab includes a collection tip at the distal end of the elongated body, the collection tip having a second geometric layout and configured to collect samples in the nasal passageway. The first geometric layout is different from the second geometric layout.

Abstract: Disclosed herein are novel compounds of Formula (1) and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, and methods of using the same.

Abstract: A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Disclosed are devices and methods for measuring lung respiration volume including processor means for receiving a detected series of heart beats, measuring variability between a period of successive beats, identifying the start and finish of successive breaths by the maxima and minima in the period, identifying the amplitude of variability of period between successive breaths, and thereby determining a value for a measurement of an extent of lung respiration, and output means for generating the value for the measurement of the extent of lung respiration. The disclosed devices and methods have applications in different medical fields. The disclosed devices can be utilised as wearable devices, wherein the signals are generated and may be processed remotely or locally.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.