Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.

Abstract: A hanger for suspending tiles or panels from a ceiling or roof, and a ceiling system incorporating the hanger, is provided. The hanger comprises a suspension member securable to the ceiling, having a longitudinal axis, and a panel mount coupled to the suspension member and releasably securable to each of a multiple panels to hold the multiple panels in a spaced relation from the ceiling on a common plane.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A hanger and a ceiling suspension system incorporating the hanger, for suspending a suspension rail from a ceiling are provided, where the suspension rail is configured to support an object. The hanger includes a first suspension member and a second suspension member positioned adjacent to one another. The first and second suspension members each have an upper portion, a lower portion, and a coupling component situated between the upper and lower portions. The upper portions are configured to be releasably suspended from the ceiling. The lower portions are configured to releasably engage the suspension rail. The coupling components are engageable to form a hinge connection between the first and second suspension members. Separation of the upper portions from one another biases the lower portions towards one another to releasably engage the suspension rail between the suspension members.

Abstract: According to one aspect of the disclosure, packaging for a sterile syringe having a nominal size of less than 1 mL may include a flexible tray having a cavity for containing the syringe. The cavity may include an opening, one or more sidewalls, and a base. A lip may surround the opening, may extend radially outward from the cavity, and may define a periphery of the tray. A removable cover may have a periphery that is adhered to the lip, and the removable cover may be permeable to a gaseous sterilant, including one or more of vaporized hydrogen peroxide or ethylene oxide. A projection may be associated with the base of the cavity and may extend away from the base of the cavity in a direction opposite to the opening of the cavity.

Abstract: Access to attachments of electronic messages and information associated with the electronic messages to applications external to a messaging application is provided. A message including an attachment is received via a messaging application, and a relationship connecting the message to the attachment is stored in a graph database. When a request is made to display a file list, an API is used to interact with the graph database. Attachments that meet a criterion associated with the file list and associated metadata are included in the list. Responsive to a selection to open an attachment, a productivity application communicates with the messaging application to retrieve the attachment and associated messages, and displays the attachment in a content display region and associated messages and messaging application functionalities in a communications pane in a single productivity application user interface.

Abstract: A hanger and a ceiling suspension system incorporating the hanger, for suspending a suspension rail from a ceiling are provided, where the suspension rail is configured to support an object. The hanger includes a first suspension member and a second suspension member positioned adjacent to one another. The first and second suspension members each have an upper portion, a lower portion, and a coupling component situated between the upper and lower portions. The upper portions are configured to be releasably suspended from the ceiling. The lower portions are configured to releasably engage the suspension rail. The coupling components are engageable to form a hinge connection between the first and second suspension members. Separation of the upper portions from one another biases the lower portions towards one another to releasably engage the suspension rail between the suspension members.

Abstract: An eyewear fit visualization system and method enable a user to visualize the fit and look of eyewear on the user's face without physically wearing the eyewear. An image of a user's face is converted to a three-dimensional map that is used to determine contact points of the eyewear to the user's face. Using these contact points, the system and method displays the eyewear precisely in place on a reflected or displayed image of the user's face to accurately simulate the look and fit of the eyewear.

Abstract: An eyewear fit visualization system and method enable a user to visualize the fit and look of eyewear on the user's face without physically wearing the eyewear. An image of a user's face is converted to a three-dimensional map that is used to determine contact points of the eyewear to the user's face. Using these contact points, the system and method displays the eyewear precisely in place on a reflected or displayed image of the user's face to accurately simulate the look and fit of the eyewear.

Abstract: An oceanographic sensor mooring section for use with standard oceanographic moorings comprising: mooring oceanographic equipment, such as floatation devices and sensors; and a subsurface power generation unit connected to the mooring oceanographic equipment, wherein the mooring section has connective swivels at opposing ends thereof for attachment of the mooring section to standard oceanographic moorings, mooring lines, or mooring anchors, to allow the mooring section to independently orient in the direction of current flow. The subsurface power generation unit comprises a battery and power management/tracking electronics and a rim turbine generating unit that harnesses the power of underwater currents to power any sensors and related electronics equipment.

Abstract: A method includes, responsive to receiving a user login, displaying a user interface on a display screen of a computing device. The user interface includes a menu listing multiple pills that are associated with different performance topics. The user interface includes a large work space and multiple small work spaces. The method includes receiving a first data visualization and a second data visualization from a visualization database remote from the computing device via a network. The first data visualization represents the performance topic associated with a first pill of the pills, and the second data visualization representing a performance topic associated with a second pill of the pills. The method also includes concurrently displaying the first data visualization within a first small work space of the small work spaces and the second data visualization within the large work space.

Abstract: A hanger for suspending tiles or panels from a ceiling or roof, and a ceiling system incorporating the hanger, is provided. The hanger comprises a suspension member securable to the ceiling, having a longitudinal axis, and a panel mount coupled to the suspension member and releasably securable to each of a multiple panels to hold the multiple panels in a spaced relation from the ceiling on a common plane.

Abstract: The present application describes a machine learning method for detecting tamper. The method includes a step of training a model using one or more values obtained from one or more different sensors on an integrated module. The one or more values act as training data with respect to one or more of light, acceleration, magnetic field, rotation, temperature, pressure, humidity, and audio. The method also includes a step of predicting, via the trained model, tampering of the of the integrated module. The present application also describes a system for detecting tamper.

Abstract: The present application describes an integrated module. The integrated module includes a microcontroller, an inertial measurement unit (IMU), a low-power accelerometer, and an environmental sensor. A distance between the environmental sensor and the IMU is greater than a distance between the IMU and the low-power accelerometer. The present application also describes a method of making an integrated module. The present application also describes a tamper detection system.

Abstract: The present application includes a computer-implemented method for detecting a tamper event. The method includes a step of receiving, from one or more sensors on an integrated module, data indicating one or more of light, acceleration, magnetic field, rotation, temperature, pressure, humidity, and audio. The method also includes a step of transmitting, to a microcontroller/evaluation engine coupled to the integrated module, the received data from the one or more sensors. The method further includes a step of determining, via the microcontroller, the received data exceeding one or more configurable thresholds of the tamper event. The method even further includes a step of assigning, via the microcontroller, a score associated with each of the one or more configurable thresholds being exceeded by the received data. The method yet even further includes a step of collecting, via the microcontroller, an aggregate total based on the assigning step.

Abstract: A wheel force transducer stator angle correction apparatus. The apparatus includes a stator rod retainer having a through-bore, the stator rod retainer being in mechanical communication with at least one bearing. The apparatus also includes a stator rod having a first portion rigidly attached to an encoder stator attached to a wheel and having a second portion disposed within the through-bore of the stator rod retainer. The apparatus also includes an encoder rigidly attached to a portion of a vehicle associated with the wheel, wherein the encoder is adapted to measure an angle of the stator rod and to adjust at least one value associated with a wheel speed of the wheel based on the measured angle of the stator rod.

Abstract: A system and method for providing a user of communications services with free market based pricing may include providing for communications over one of multiple network paths serviced by multiple respective communications service providers via at least one communications network. One of the network paths over which to communicate based on current pricing from the multiple communications service providers may be selected and communications may be performed over the selected network path.

Abstract: Medical instruments with variable bending stiffness profiles are disclosed. A medical instrument can include a bending stiffness profile comprising a plurality of bending stiffness zones of substantially constant bending stiffness separated by transition zones. The bending stiffness profile can be achieved by modulating various modalities of the medical instrument along its length. A compound medical instrument can include a scope telescoping within a sheath. A variable bending stiffness profile of the compound medical instrument can be modulated by adjusting the relative position of the scope and the sheath.