Abstract: The present application includes a computer-implemented method for detecting a tamper event. The method includes a step of receiving, from one or more sensors on an integrated module, data indicating one or more of light, acceleration, magnetic field, rotation, temperature, pressure, humidity, and audio. The method also includes a step of transmitting, to a microcontroller/evaluation engine coupled to the integrated module, the received data from the one or more sensors. The method further includes a step of determining, via the microcontroller, the received data exceeding one or more configurable thresholds of the tamper event. The method even further includes a step of assigning, via the microcontroller, a score associated with each of the one or more configurable thresholds being exceeded by the received data. The method yet even further includes a step of collecting, via the microcontroller, an aggregate total based on the assigning step.

Abstract: The invention is directed broadly to a method of preparing a texture modified starch-based food product, comprising the steps: (a) dehydrating a starch-based food to remove excess water; (b) grinding the dehydrated starch-based food to form a fine powder; (c) adding a carrier to coat the fine powder; (d) rehydrating the coated powder to form a paste; and (e) forming the paste into the texture modified starch-based food product shaped and textured to a generic serve of the starch-based food selected to form the paste.

Abstract: The present invention relates to methods for purifying bacterial polysaccharides, in particular for removing impurities from cellular lysates of bacteria producing polysaccharides.

Abstract: The invention is directed broadly to a method of preparing a texture modified food product, comprising the steps: (a) providing a partially cooked fruit or vegetable; (b) comminuting the partially cooked fruit or vegetable to form a paste; and (c) moulding the paste to form the texture modified food product which is shaped and/or textured into a generic shape of the fruit or vegetable selected to form the paste.

Abstract: According to one aspect of the disclosure, packaging for a sterile syringe having a nominal size of less than 1 mL may include a flexible tray having a cavity for containing the syringe. The cavity may include an opening, one or more sidewalls, and a base. A lip may surround the opening, may extend radially outward from the cavity, and may define a periphery of the tray. A removable cover may have a periphery that is adhered to the lip, and the removable cover may be permeable to a gaseous sterilant, including one or more of vaporized hydrogen peroxide or ethylene oxide. A projection may be associated with the base of the cavity and may extend away from the base of the cavity in a direction opposite to the opening of the cavity.

Abstract: The present application describes an integrated module. The integrated module includes a microcontroller, an inertial measurement unit (IMU), a low-power accelerometer, and an environmental sensor. A noise target between the IMU and low-power accelerometer is less than a noise target be the IMU and microcontroller. The present application also describes a method of using an integrated module.

Abstract: A method includes, responsive to receiving a user login, displaying a user interface on a display screen of a computing device. The user interface includes a menu listing multiple pills that are associated with different performance topics. The user interface includes a large work space and multiple small work spaces. The method includes receiving a first data visualization and a second data visualization from a visualization database remote from the computing device via a network. The first data visualization represents the performance topic associated with a first pill of the pills, and the second data visualization representing a performance topic associated with a second pill of the pills. The method also includes concurrently displaying the first data visualization within a first small work space of the small work spaces and the second data visualization within the large work space.

Abstract: A medical instrument can have an elongated shaft, at least three bending stiffness zones arranged along a length of the elongated shaft, and at least two transition zones that have a variable bending stiffness extending over a length thereof. Each bending stiffness zone can have a bending stiffness that extends over a length of the bending stiffness zone. The variable bending stiffness of each transition zone can vary from a first bending stiffness on a first side of the transition zone to a second bending stiffness on a second side of the transition zone.

Abstract: According to one aspect of the disclosure, packaging for a sterile syringe having a nominal size of less than 1 mL may include a flexible tray having a cavity for containing the syringe. The cavity may include an opening, one or more sidewalls, and a base. A lip may surround the opening, may extend radially outward from the cavity, and may define a periphery of the tray. A removable cover may have a periphery that is adhered to the lip, and the removable cover may be permeable to a gaseous sterilant, including one or more of vaporized hydrogen peroxide or ethylene oxide. A projection may be associated with the base of the cavity and may extend away from the base of the cavity in a direction opposite to the opening of the cavity.

Abstract: The present application describes an integrated module. The integrated module includes a microcontroller, an inertial measurement unit (IMU), a low-power accelerometer, and an environmental sensor. A distance between the environmental sensor and the IMU is greater than a distance between the IMU and the low-power accelerometer. The present application also describes a method of making an integrated module. The present application also describes a tamper detection system.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The invention is directed broadly to a method of preparing a texture modified food product for consumption by a dysphagic consumer, comprising the steps: (a) providing a cooked fish or meat; (b) comminuting the cooked fish or meat to form a paste; and (c) forming the paste into the texture modified food product shaped and textured to a generic serve of the fish or meat selected to form the paste.

Abstract: An oxygen transporter device configured to transport O2 from an ambient air location into or toward a subcutaneous site. The device includes an absorption component, a cannula, and a discharge component configured to be implanted in a subcutaneous location while the absorption component is not subcutaneous. The cannula can extend through or across the skin of a patient. The discharge component can includes one or more multi-layered, flexible mesh sheets, which are coupled to cells.

Abstract: A stator angle is determined to correct a value measured by a wheel force transducer. A mounting bracket is rigidly attached to a vehicle and supports a housing within which a rotary encoder is mounted. A stator rod retainer is aligned with a rotational axis of the rotary encoder and has a through-bore extending perpendicular to the rotational axis. The stator rod retainer rotates relative to a stationary portion of the rotary encoder using at least one bearing, and the stator rod retainer supports a first end of a stator rod for substantially free movement through the through-bore. A controller determines, when the second end of the stator rod is fixedly attached to an encoder stator attached to a wheel, a stator angle of the stator rod used for adjusting at least one value associated with the wheel that is measured using the encoder stator.

Abstract: Medical instruments with variable bending stiffness profiles are disclosed. A medical instrument can include a bending stiffness profile comprising a plurality of bending stiffness zones of substantially constant bending stiffness separated by transition zones. The bending stiffness profile can be achieved by modulating various modalities of the medical instrument along its length. A compound medical instrument can include a scope telescoping within a sheath. A variable bending stiffness profile of the compound medical instrument can be modulated by adjusting the relative position of the scope and the sheath.

Abstract: An improved three-dimensional structure and method and system of making same is provided, wherein the method for forming the three-dimensional structure comprises: coating a filament with a curable resin; directing a first portion of the coated filament around a plurality of pins fixed to and extending outwardly from a frame, the coated filament directed to intersect according to a pre-set pattern, the coated filament forming a first filament layer; directing a second portion of the coated filament about said pins forming one or more subsequent filament layers aligned and in contact with the first filament layer, the filament layers collectively forming a filament stack, the filament stack having a predetermined height and defining the intersecting panel elements; and curing the curable resin such that it hardens and retains the individual filament layers forming the filament stack in a three-dimensional shape.

Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.

Abstract: A wheel force transducer stator angle correction apparatus. The apparatus includes a stator rod retainer having a through-bore, the stator rod retainer being in mechanical communication with at least one bearing. The apparatus also includes a stator rod having a first portion rigidly attached to an encoder stator attached to a wheel and having a second portion disposed within the through-bore of the stator rod retainer. The apparatus also includes an encoder rigidly attached to a portion of a vehicle associated with the wheel, wherein the encoder is adapted to measure an angle of the stator rod and to adjust at least one value associated with a wheel speed of the wheel based on the measured angle of the stator rod.