Abstract: Apparatus and methodologies are provided to improve the refrigeration system by precisely controlling refrigerator compartment and heat exchanger temperatures through continuous modulation of device speeds or positions to match capacity with instantaneous load. A controller in a refrigerator is configured to provide a plurality of control loops to control various operational aspects of selected components in the refrigerator. A first loop controls the operating speed of a compressor based on temperature of the evaporator or based on the desired speed of an evaporator fan. A second control loop controls speed of an evaporator fan to maintain a prescribed freezer compartment temperature. A third control loop maintains a prescribed temperature in a fresh food compartment. In certain embodiments selected of the control loops may be thermodynamically coupled by way of thermal interaction between the various cooled compartments rather than being electrically coupled.

Abstract: Apparatus and methodologies are provided to monitor temperature from at least two locations on an evaporator in a refrigeration system. Operational characteristics of one or more of the compressor, condenser and evaporator cooling fans are adjusted based on the difference in temperature between the two locations on the evaporator. In some systems a second evaporator may be provided along with a refrigerant control valve. Cooling air flow across the second evaporator and refrigerant distribution between the plural evaporators may also be control.

Abstract: A consumer refrigeration appliance, such as a refrigerator, includes a refrigeration system charged with a refrigerant and further having a compressor, a condenser, an expansion device, and an evaporator. At least one of the evaporator or condenser is a spine fin heat exchanger having a defined length of tube with a spine fine material configured around at least a portion of tube. The tube has a reduced refrigerant side diameter that provides a reduced refrigerant side area defined by the tube length and refrigerant side diameter. The refrigeration system has a reduced refrigerant charge mass.

Abstract: A refrigerator and a method of operating a refrigerator to determine the time at which to initiate a defrost cycle is provided. Changes in the voltage provided to an evaporator fan are used to determine and/or predict when to initiate a defrost cycle. Adjustments to the timing of the defrost cycle can be made based on known periods of peak energy demand and/or the increased costs associated with operating the defrost cycle during such peak energy demand periods.

Abstract: In controlling an engine, an amount of an intake charge provided, during operation of the engine, to a combustion chamber of the engine is determined. The intake charge includes an air component, a fuel component and a diluent component. An amount of the air component of the intake charge is determined. An amount of the diluent component of the intake charge is determined utilizing the amount of the intake charge, the amount of the air component and, in some instances, the amount of the fuel component. An amount of a diluent supplied to the intake charge is adjusted based at least in part on the determined amount of diluent component of the intake charge.

Abstract: An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.

Abstract: An SBS-formatted microfluidic device where the geometry of the plate defines an array of interrogation areas, and where each interrogation area encompasses at least one reaction site.

Abstract: An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.

Abstract: The invention provides microfluidic devices and methods for carrying out sequential binary reactions.

Abstract: A microfluidic device adapted to perform many simultaneous binding assays including but not limited to immunological experiments, such as ELISA assays, with minimal cross-talk between primary and secondary antibodies.

Abstract: In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines.

Abstract: An SBS-formatted microfluidic device where the geometry of the plate defines an array of interrogation areas, and where each interrogation area encompasses at least one reaction site.

Abstract: In controlling an engine, an amount of an intake charge provided, during operation of the engine, to a combustion chamber of the engine is determined. The intake charge includes an air component, a fuel component and a diluent component. An amount of the air component of the intake charge is determined. An amount of the diluent component of the intake charge is determined utilizing the amount of the intake charge, the amount of the air component and, in some instances, the amount of the fuel component. An amount of a diluent supplied to the intake charge is adjusted based at least in part on the determined amount of diluent component of the intake charge.

Abstract: The present invention provides methods of and systems for translating conditions from a small-volume experiment to a larger-volume experiment.

Abstract: An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.

Abstract: An ultrasound system for inspecting an object is provided. The ultrasound system includes an electromagnetic acoustic transducer (EMAT) and a pulser-receiver system. The EMAT is configured to generate acoustic signals representative of the area being inspected and comprises a flux concentrating non-conductive pole piece separating a radio frequency (RF) coil and a magnet. The pulser-receiver system is coupled to the EMAT and configured to receive the acoustic signals and convert the acoustic signal to electrical signals.

Abstract: New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.

Abstract: A pulsed eddy current pipeline inspection device is provided. The pulsed eddy current pipeline inspection device comprises a plurality of stages longitudinally spaced apart from each other and adapted to move between a contracted position and an expanded position, and a plurality of sensors disposed around at least a portion of a circumference of each of the plurality of stages in the contracted position with at least one gap between sensors in each of the plurality of stages in the expanded position, the plurality of sensors being arranged such that the at least one gap in a first one of the plurality of stages is aligned with a portion of a second one of the plurality of stages that has sensors disposed thereon.

Abstract: A pulsed eddy current pipeline inspection device is provided. The pulsed eddy current pipeline inspection device comprises a plurality of stages longitudinally spaced apart from each other and adapted to move between a contracted position and an expanded position, and a plurality of sensors disposed around at least a portion of a circumference of each of the plurality of stages in the contracted position with at least one gap between sensors in each of the plurality of stages in the expanded position, the plurality of sensors being arranged such that the at least one gap in a first one of the plurality of stages is aligned with a portion of a second one of the plurality of stages that has sensors disposed thereon.

Abstract: A microfluidic device adapted to perform many simultaneous binding assays including but not limited to immunological experiments, such as ELISA assays, with minimal cross-talk between primary and secondary antibodies.