Abstract: The present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding molecule that specifically binds human PSMA. In certain embodiments, the bispecific antigen- binding molecules of the present invention are capable of inhibiting the growth of tumors expressing PSMA, such as prostate tumors. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an up-regulated or induced targeted immune response is desired and/or therapeutically beneficial.

Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A method of forming a coating of an Al—Zn—Si—Mg alloy on a steel strip to form an Al—Zn—Mg—Si coated steel strip is disclosed. The method includes the steps of dipping steel strip into a bath of molten Al—Zn—Si—Mg alloy and forming a coating of the alloy on exposed surfaces of the steel strip and cooling the coated strip with cooling water. The cooling step includes controlling the pH of cooling water to be in a range of pH 5-9. Particular embodiments focus on Al—Zn—Si—Mg alloys that contain the following elements in % by weight: Zn: 2 to 19, Si: 0.01 to 2, Mg: 1 to 10, and Balance Al and unavoidable impurities.

Abstract: A seating assembly for a vehicle includes a backrest extending between a first surface and a second surface. The second surface opposes the first surface. A first seat base operably couples with the backrest to form a first seat of the seating assembly. The backrest is pivotable between a first use position and a second use position. A second seat base is operably coupled via a connection interface with the backrest. The second seat base and the backrest form a second seat of the seating assembly in the second use position. The second seat faces away from the first seat in the second use position. A cross-sectional plane intersecting each of the first surface and the second surface defines a cross-sectional area of the backrest that remains constant between the first use position and the second use position of the backrest.

Abstract: A vehicle includes a first seat. A seat base is selectively coupled to the first seat via an engaging member extending from a proximal end of the seat base. The seat base has an attached configuration and a detached configuration. The seat base couples with the first seat and forms a second seat facing away from the first seat in the attached configuration. The seat base is decoupled from the first seat in the detached configuration. A backrest is common to the first and second seats in the attached configuration. A frame structure operably couples the first seat with the vehicle. The frame structure includes a receiving member interfacing with the seat base. The engaging member engages the receiving member to couple the seat base with the backrest.

Abstract: A vehicle includes a passenger compartment. A wall is positioned within the passenger compartment. A support structure is positioned on the wall. The support structure defines a series of slots. A seating assembly engages at least one of the slots of the series of slots such that the seating assembly is suspended above a floor of the passenger compartment.

Abstract: A seating assembly for a vehicle includes a first seat including a first seat base coupled with a backrest. A second seat includes a seat back and a second seat base pivotably coupled with the seat back and moveable between a stowed position and a deployed position. A locking feature between the second seat base and the seat back is moveable between a locked position and an unlocked position. The locking feature engages the second seat base in the locked position. The locking feature is disengaged from the second seat base in the unlocked position. A connection interface between the backrest and the seat back includes an engaging member and a receiving member. The engaging member selectively engages the receiving member to secure the second seat to the first seat in an attached configuration.

Abstract: A seating system for a vehicle includes a first sidewall and a second sidewall. A second sidewall opposes the first sidewall. The first sidewall and the second sidewall at least partially define a cargo space. A first seating assembly is coupled to the first sidewall. A second seating assembly is coupled to the first sidewall. A bench seat is configured to be selectively adjustable between an adjacent support position and a cross support position. The bench seat is coupled to the first seating assembly and the second seating assembly when in the adjacent support position. The bench seat is coupled to the first sidewall and the second sidewall in the cross support position.

Abstract: A vehicle seating system includes a support feature coupled to a sidewall within a cargo space of a vehicle. A seating assembly is coupled to the support feature. The seating assembly is rotatable between a stowed position and a deployed position. The seating assembly includes a seat base having a proximal end coupled to the support feature and a distal end. The distal end of the seat base is disposed adjacent to the sidewall in the stowed position. The seating assembly also includes a leg support coupled to the distal end of the seat base. The leg support is operable between a storage position and a support position.

Abstract: The present application relates generally to filter media useful for manufacturing air filters for residential and commercial office's Heating, Ventilation, and Air Conditioning (HVAC), particularly to filters and filter media comprising soybean-based materials. The present invention provides an inexpensive, effective, environmentally friendly, and sustainable media for manufacturing HVAC air filters for residential and commercial buildings.

Abstract: Techniques for ensuring content output to a user conforms to a quality of the user's speech, even when a speechlet or skill ignores the speech's quality, are described. When a system receives speech, the system determines an indicator of the speech's quality (e.g., whispered, shouted, fast, slow, etc.) and persists the indicator in memory. When the system receives output content from a speechlet or skill, the system checks whether the output content is in conformity with the speech quality indicator. If the content conforms to the speech quality indicator, the system may cause the content to be output to the user without further manipulation. But, if the content does not conform to the speech quality indicator, the system may manipulate the content to render it in conformity with the speech quality indicator and output the manipulated content to the user.

Abstract: The present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding molecule that specifically binds human MUC16. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing MUC16, such as ovarian tumors. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an up-regulated or induced targeted immune response is desired and/or therapeutically beneficial.

Abstract: A system for categorizing, visualizing, and recommending cannabis products based on objective data of the chemical composition of products is described. This system allows cannabis products to be visualized and compared based on their chemical composition, even by laypeople with little or no knowledge of the underlying objective data. A recommendation system is built upon this which can recommend products for consumption, including a user interface for receiving user input, which includes at least one of demographic data, desired level of psychoactivity, or prior experience with the product, a merchant interface for receiving merchant input, including at least one of general data descriptive of the regulated product, lab data descriptive of the regulated products chemical composition, and user data descriptive of subjective effects of the regulated product on a user; and a decision engine making a recommendation of product according to correlation of the lab data with the user data.

Abstract: The present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding molecule that specifically binds human PSMA. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing PSMA, such as prostate tumors. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an up-regulated or induced targeted immune response is desired and/or therapeutically beneficial.

Abstract: The present disclosure provides for a wrist arthroplasty system and method that enable an expedient surgical procedure, maintain wrist motion, and reduce the likelihood of implant loosening. The system includes a capitate implant, a radial implant, and a resection instrument. The capitate implant includes a convex head formed to interface with a concave socket of the radial implant. The capitate implant includes a single stem formed to be secured within a patient's capitate bone. The radial implant includes lips formed to increase wrist joint motion and to help prevent dislocation of the capitate implant from the radial implant. The resection instrument may be used in combination as a measurement tool for determining the proper implant size, a guide for properly positioning the implants, and a trial tool for testing trial implant components before securing the final radial and capitate implants.

Abstract: Disclosed herein are various embodiments for a media device upgrading system with a native user interface. An embodiment operates by displaying a native user interface of a media device configured to operate in both a normal mode without an upgrader device and an upgrader mode when an upgrader device is connected to an input port of the media device. It is determined that the upgrader device is connected a command is received via the native user interface. It is determined that the command operates a software component, and the command is provided to the upgrader device. A response to executing the command is received from the upgrader device, and a response is displayed on the native user interface.

Abstract: In the context of a co-browse session, one of the participants elects to include a screenshare task in which a screenshare of a browser window displaying a website will be provided to other participants of the co-browse session. When the screenshare task is started, a location of an address bar of the web browser is identified, optional pre-processing is applied to the image of the address bar, and a character recognition process, is used to determine the characters of the URL in the browser's address bar. The URL is compared with a list of allowed website URLs, and the screenshare session is selectively allowed only if the URL is contained in the list of allowed URLs. Once the URL has been approved, a slice of pixels the address bar is obtained and monitored for changes to the pixels that may indicate a change to the URL.

Abstract: A ventilation system for an appliance that generates an exhaust fluid when used. The appliance being provided within an interior of environment. The ventilation system being fluidly coupled to a ventilator operably coupled to the environment. The ventilation system can include a suction source in fluid communication with the appliance and the exhaust fluid, and a duct fluidly coupling the suction source to the ventilator.

Abstract: A packaging comprising a tray having an opening, a cavity including at least three cavity portions, a plurality of sidewalls, and a base; and a sterile syringe contained within the cavity, wherein the sterile syringe is pre-filled with a medicament or other fluid; wherein a first cavity portion comprises a plunger rod of the sterile syringe, a second cavity portion comprises a barrel of the sterile syringe, and a third cavity portion comprises a needle attachment portion of the sterile syringe, wherein the at least three cavity portions are connected to one another by intermediate narrowed portions, and wherein each of the narrowed portions includes a first sidewall, a second sidewall, a base, and a plurality of geometric features projecting into the narrowed portions to position the sterile syringe away from the plurality of sidewalls.

Abstract: A method of improving surface roughness of ceramic matrix composites (CMCs) is provided. The method includes completing a formation of the CMCs and a chemical vapor infiltration (CVI) process to initially coat the CMCs, inspecting a CMC surface, identifying, from a result of the inspecting, a defect in the CMC surface that negatively impacts a surface roughness characteristic thereof, locally targeting and ablating the defect and re-inspecting the CMC surface to ensure that the defect is correct.