Abstract: A method of compressing a breast of a patient with a breast imaging system includes obtaining an x-ray area of the breast of the patient. The x-ray area of the breast is compared to a data set, and a target force is based at least in part on the comparison is identified. A compressive force is applied to the breast, and is based at least in part on the target force. The breast is imaged with the breast imaging system.

Abstract: Proto-antigen-presenting surfaces and related kits, methods, and uses are provided. The proto-antigen-presenting surface can comprise a plurality of primary activating molecular ligands comprising a major histocompatibility complex (MHC) molecule configured to bind to a T cell receptor (TCR) of a T cell and a plurality of co-activating molecular ligands each including a TCR co-activating molecule or an adjunct TCR activating molecule, wherein an exchange factor is bound to the MHC molecules. Exchange factors include, e.g., dipeptides such as GL, GF, GR, etc. Proto-antigen-presenting surfaces can be used to rapidly prepare antigen-presenting surfaces comprising one or more peptide antigens of interest by contacting the proto-antigen-presenting surface with one or more peptide antigens so as to displace the exchange factor. As such, the disclosure facilitates rapid evaluation of the immunogenicity of peptide antigens for activating T lymphocytes.

Abstract: Provided herein are biotechnology reagents provided with a poloxamer excipient. In particular, haloalkane-linked fluorophores are provided in solution or a lyophilized formulation with a poloxamer that allows for storage, accurate dispensing/measurement, reconstitution, and addition to complex biological samples without the requirement of organic solvents.

Abstract: The present invention concerns a method for preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.

Abstract: The present invention relates to a compound of the Formula: or a pharmaceutically acceptable salt thereof. The compound of the present invention inhibits Pol?. This novel therapeutic compound is therefore useful for the treatment and/or prevention of diseases and conditions in which Pol? activity is implicated, such as, for example but not limited to, the treatment and/or prevention of cancer. The present invention also relates to pharmaceutical compositions comprising the novel therapeutic compound defined herein, to processes for synthesising the compound and to their use for the treatment of diseases and/or conditions in which Pol? activity is implicated.

Abstract: Retractable stairs for mounting in an exterior doorway of a recreational vehicle are provided with a spaced apart stringers and a tread extending between the stringers. Spaced apart straps are connected to upper ends of the stringers and are pivotally mounted to a floor in an interior space of the recreational vehicle to allow movement of the stringers and the tread through the exterior doorway between a retracted position stowed within the recreational vehicle and a deployed position outside of the recreational vehicle. A threshold plate is positioned between the straps and is fixed against movement during the pivoting movement of the straps. Locking latches extend outwardly from the stringers and are positionable for engaging a jamb of the exterior doorway for releasably securing the stringers and the tread in the retracted position. Extensible support legs are mounted on the stringers and extendable downwardly below the stringers to engage a ground surface for supporting the retractable stairs.

Abstract: A time resolved reflectivity metrology device images structures underlying layers using a pulsed pump beam and pulsed probe beam with at least one time delay between the pulses. One or both beams are modulated. A camera with a multi-pixel array and independent phase locking for each pixel in the multi-pixel array receives and demodulates the reflected probe beam to generate images. The camera may record a change in reflectivity or surface deformation of the target sample at every pixel as a function of at least one time delay between the pump pulses and the probe pulses, with which at least one property of the target sample may be characterized.

Abstract: Methods and systems for managing operation of data processing systems are disclosed. The data processing systems may include a limited number of hardware components. To increase the usable number or types of hardware components, an add-in card or other device may be attached to the data processing system. When connected to the data processing system, these devices may consume power delivered by the data processing system. The devices may cooperate with the host data processing system so that power is consumed in a manner that is less likely to negatively impact operation of the devices and host system.

Abstract: An information handling system includes a printed circuit board, a surface mount connector including first and second surface mount connector portions, first and second different pairs, and a ground plane. The first and second surface mount connector portions are mounted on the printed circuit board. The first differential pair is located on the first surface mount connector portion, and the second differential pair is located on the second surface mount connector portion. The ground plane is located in between the first and second surface mount connector portions within the printed circuit board. The first ground via is in physical communication with the ground plane and a first ground pad on a surface of the printed circuit board. The second ground via is in physical communication with the ground plane and a second ground pad on the surface of the printed circuit board.

Abstract: The present invention relates to a compound of the Formula: or a pharmaceutically acceptable salt thereof. The compound of the present invention inhibits Pol?. This novel therapeutic compound is therefore useful for the treatment and/or prevention of diseases and conditions in which Pol? activity is implicated, such as, for example but not limited to, the treatment and/or prevention of cancer. The present invention also relates to pharmaceutical compositions comprising the novel therapeutic compound defined herein, to processes for synthesising the compound and to their use for the treatment of diseases and/or conditions in which Pol? activity is implicated.

Abstract: The present invention relates to a compound of the Formula: or a pharmaceutically acceptable salt thereof. The compound of the present invention inhibits Pol?. This novel therapeutic compound is therefore useful for the treatment and/or prevention of diseases and conditions in which Pol? activity is implicated, such as, for example but not limited to, the treatment and/or prevention of cancer. The present invention also relates to pharmaceutical compositions comprising the novel therapeutic compound defined herein, to processes for synthesising the compound and to their use for the treatment of diseases and/or conditions in which Pol? activity is implicated.

Abstract: An articulated machine is described. The articulated machine includes a leading frame portion and a trailing frame portion, each defining a first side and a second side. The articulated machine includes at least one first traction device provided on the first side, and at least one second traction device provided on the second side of the leading frame portion and the trailing frame portion. The articulated machine includes a system to selectively steer the articulated machine towards a first side direction and a second side direction. The system includes a controller to receive a steering input and alter motion parameter of one of the at least one first traction device and the at least one second traction device with respect to the other to turn one of the leading frame portion and the trailing frame portion with respect to the other.

Abstract: Provided herein are, inter alia, methods, compositions and kits for treating, preventing and diagnosing coronaviruses, specifically COVID-19. Also included herein are kits for treating, preventing and diagnosing coronaviruses, specifically COVID-19.

Abstract: Embodiments of the present disclosure provide a system and method for contingency wagering. The system provides a first user interface (UI) to create a plurality of user accounts and a second UI to establish connection between the plurality of user accounts. Further, the system provides display of a plurality of contingency wagers and enables each user to select at least one contingency wager of the plurality of contingency wagers. The system sends a notification to each user account of a set of users accounts of the plurality of user accounts, based on selection of the at least one contingency wager by at least one user account of the plurality of user accounts other than the set of user accounts. The notification includes a plurality of links, where a first link of the plurality of links corresponds to a copy operation on the at least one contingency wager.

Abstract: A chip brush assembly includes a main body defining longitudinal and transverse axes defining a plane. The body has a central portion extending in the plane and at least two slots extend therein. At least one central shaft passageway extends therethrough parallel to the transverse axis. The body has a first end portion extending in the plane and away from the central portion parallel to the transverse axis and has at least one first end shaft passageway extending parallel to the longitudinal axis. The body has a second end portion extending away from the central portion askew to the plane and has at least one second end shaft passageway extending askew to the plane. At least two magnetic feet assemblies are retained in the at least two slots respectively. At least one brush shaft with a chip brush is disposed in at least one of the shaft passageways.

Abstract: Provided herein are compositions and methods for the design of synthetic regulatory sequences and for subsequent modulation of neural pathways.

Abstract: A method for printing onto a substrate is disclosed. An ink is printed onto a liquid polymer layer to form a printed polymer layer. Printed substrates are also disclosed.

Abstract: Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

Abstract: Methods for developing engineered T-cells for immunotherapy that are both non-alloreactive and resistant to immunosuppresive drugs. The present invention relates to methods for modifying T-cells by inactivating both genes encoding target for an immunosuppressive agent and T-cell receptor, in particular genes encoding CD52 and TCR. This method involves the use of specific rare cutting endonucleases, in particular, TALE-nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides, to precisely target a selection. of key genes in T-cells, which are available from donors or from culture of primary cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer and viral infections.