Abstract: Embodiments facilitate interoperability and secure determination of healthcare costs. An entity may receive a first Electronic Health Record (EHR) sub-block with patient medical coverage information and first treatments and may transmit a first Device Drug Information (DIR) sub-block comprising first treatment classes corresponding to each first treatment, first treatment class members corresponding to each first treatment class, and corresponding first treatment class member cost information. In response, the entity may receive a second EHR sub-block comprising second treatments each: associated with a corresponding first treatment, and selected from corresponding first treatment class members. Upon receipt of a transaction confirmation, the entity may augment a multi-dimensional blockchain with a multi-dimensional block formed by linking: a DIR block including second treatment information, an EHR block including information based on the second EHR sub-block and a transaction block.

Abstract: Embodiments facilitate interoperability and secure patient selection for clinical trials and drug/device deployments. An entity may obtain a first set of health parameters and collective demographic information associated with one or more population segments and receive Electronic Health Record (EHR) sub-blocks with patient profile information and corresponding patient medical histories for patients. The entity may determine a subset of eligible candidate patients for a treatment based on information in the EHR sub-blocks and eligibility criteria for the treatment, which may be based the first set of health parameters, and/or the collective demographic information.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A layered drug delivery device which includes a polymeric tissue interface layer and a polymeric backing layer. The polymeric tissue interface layer includes at least one ther-apeutic agent.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods that utilize a dynamic user interface and machine learning tools to generate data-driven digital content and multivariate testing recommendations for distributing digital content across computer networks. In particular, in one or more embodiments, the disclosed systems utilize machine learning models to generate digital recommendations at multiple development stages of digital communications that are targeted on particular performance metrics. For example, the disclosed systems utilize historical information and recipient profile data to generate recommendations for digital communication templates, fragment variants of content fragments, and content variants of digital content items.

Abstract: Methods, computer systems, computer-storage media, and graphical user interfaces are provided for facilitating data visualization generation. In one implementation, dataset intent data, visual design intent data, and insight intent data determined from a user input natural language query are obtained. A set of candidate intent recommendations is generated using various combinations of the dataset intent data, visual design intent data, and insight intent data. Each of the candidate intent recommendations is incorporated into a set of visualization templates to determine eligibility of the candidate intent recommendations. For eligible candidate intent recommendations, a score associated with a corresponding visualization template is determined. Based on the scores, a candidate intent recommendation and corresponding visualizations template is selected to use as a visual recommendation for presenting a data visualization.

Abstract: An electronic construction collaboration system for managing a construction project is provided. The electronic construction collaboration system includes an Enterprise Resource Planning (ERP) sub-system including a contract engine configured to generate at least one project contract including a contract data set and ERP metadata corresponding to Building Information Modeling (BIM) metadata included in a structural object of a construction project model in a BIM sub-system and an interconnection engine configured to associatively link the ERP metadata and the BIM metadata and send the contract data set to the BIM sub-system in response to associatively linking the ERP metadata and the BIM metadata.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: An electronic construction collaboration system for managing a construction project is provided. The electronic construction collaboration system includes an Enterprise Resource Planning (ERP) sub-system including a contract engine configured to generate at least one project contract including a contract data set and ERP metadata corresponding to Building Information Modeling (BIM) metadata included in a structural object of a construction project model in a BIM sub-system and an interconnection engine configured to associatively link the ERP metadata and the BIM metadata and send the contract data set to the BIM sub-system in response to associatively linking the ERP metadata and the BIM metadata.

Abstract: A panel for forming part of a partition is disclosed. The partition may, for example, be a roof, a wall or a floor of a building. The panel comprises: a central panel; two support members; and a resiliently compressible portion. The two support members are disposed on opposed sides of the central panel, each of the two support members extending generally perpendicularly to a plane of the central panel. The resiliently compressible portion is arranged between the two support members such that a distance between the two support members can be reduced by compressing the resiliently compressible portion.

Abstract: A tile system comprises at least two tiles and at least one elongate support. Each tile is generally rectangular in shape and has a first edge, and a second edge, the second edge being generally opposite the first edge. Each elongate support has an attachment portion and a support portion. Proximate the first edge each tile is provided with a groove, the groove being configured to receive the support portion of one of the elongate supports and a portion of an adjacent tile proximate its second edge.

Abstract: The present invention relates to compounds of Formula (XI): wherein R1a, R2a, R3a, R4a, R5a, R6a, and Aa are as defined herein, and pharmaceutically acceptable salts thereof. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) inhibitors and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A server system sends links to content categories for display on a user device associated with a user. Each content category corresponds to a subset of content items. When a link to one of the content categories is selected, the corresponding subset of the content items is sent for display on the user device. The system selects a group of content items according to determined relevance scores for the user based on one or more relevance criteria and sends links to the content items in the group for display on the user device in a first order according to the relevance scores. The system adjusts the relevance scores of some content items in the group according to user feedback and resends links to the content items in the group for display on the user device in a second order according to the adjusted relevance scores.

Abstract: A graph analysis system provides a variety of graph analysis tools for analyzing graphs, such as an overall characteristics report, an entity types graph, an ego entity type graph, various histograms, and graph comparison reports. The graph analysis tools also include tools for calculating a similarity score for graphs based on characteristics and weights selected by a user.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A modular partition system comprises a plurality of panels and at least one connecting strip. Each of the plurality of panels comprises two support members extending generally perpendicularly to a plane of the modular partition system and a central panel extending between said two support panels. The plurality of panels are arranged such that the central panels of each of the plurality of panels are generally mutually parallel and one support member of each of the plurality of panels is adjacent to a support member of an adjacent panel. The at least one connecting strip cooperates with a support member from each of two of the plurality of adjacent panels so as to connect said two of the plurality of adjacent panels.

Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.