Abstract: A downhole tool having a throughbore is disclosed for use in a tubular located in a wellbore. The downhole tool has a sealing element configured to seal an annulus between the downhole tool and an inner wall of the tubular; at least one flow path formed in the downhole tool, wherein the flow path is configured to allow fluids in the annulus to flow past the sealing element when the sealing element is in a sealed position; and at least one valve in fluid communication with the flow path and configured to allow the fluids to flow through the flow path in a first direction while preventing the fluids from flowing through the flow path in a second direction. A guard may be installed proximate anchor elements. The guard extends radially beyond an outer diameter of the anchor elements when the anchor elements are in a retracted position.

Abstract: This invention relates to a novel compound which is a glycogen phosphorylase inhibitor and its use in the treatment of diabetes and other conditions associated therewith. The invention further relates to a pharmaceutical composition containing the compound and to processes for preparing the compound and pharmaceutical composition.

Abstract: This invention relates to a novel compound which is a glycogen phosphorylase inhibitor and its use in the treatment of diabetes and other conditions associated therewith. The invention further relates to a pharmaceutical composition containing the compound and to processes for preparing the compound and pharmaceutical composition.

Abstract: A clutch peak torque limiter for regulating the flow rate of fluid between a clutch master cylinder and slave cylinder in a vehicle transmission, the valve having a non-return valve for allowing free flow of fluid from the clutch master cylinder to the clutch slave cylinder, a return orifice for allowing return flow of fluid from the slave cylinder to the master cylinder, and a pressure controlled valve in parallel with the non-return valve and return orifice for allowing flow of fluid between the slave cylinder and the master cylinder, the valve opening when the pressure on either side of the pressure controlled valve exceeds a predetermined level.

Abstract: A clutch peak torque limiter for regulating the flow rate of fluid between a clutch master cylinder and slave cylinder in a vehicle transmission, the valve having a non-return valve for allowing free flow of fluid from the clutch master cylinder to the clutch slave cylinder, a return orifice for allowing return flow of fluid from the slave cylinder to the master cylinder, and a pressure controlled valve in parallel with the non-return valve and return orifice for allowing flow of fluid between the slave cylinder and the master cylinder, the valve opening when the pressure on either side of the pressure controlled valve exceeds a predetermined level.

Abstract: A product comprising separate compartments, contains first and second components of a composition and a catalyst for a reaction between the two components. In use, the two components are combined together to form the composition, preferably a cleaning composition, whose temperature is elevated when compared to the temperature of the components prior combination, providing improved performance. Method of manufacture, method of cleaning a surface, a kit, and an applicator means are disclosed.

Abstract: A toroidal inductor, including a substrate (100), a toroidal core region (434) defined within the substrate, and a toroidal coil including a first plurality of turns formed about the toroidal core region and a second plurality of turns formed about the toroidal core region. The second plurality of turns can define a cross sectional area (440) greater than a cross sectional area (442) defined by the first plurality of turns. The substrate and the toroidal coil can be formed in a co-firing process to form an integral substrate structure with the toroidal coil at least partially embedded therein. The first and second plurality of turns can be disposed in alternating succession. The toroidal core region can be formed of a substrate material having a permeability greater than at least one other portion of the substrate.

Abstract: A method for making an embedded toroidal inductor (118) includes forming in a ceramic substrate (100) a first plurality of conductive vias (102) radially spaced a first distance from a central axis (101) so as to define an inner circumference. A second plurality of conductive vias (104) is formed radially spaced a second distance about the central axis so as to define an outer circumference. A first plurality of conductive traces (110) forming an electrical connection between substantially adjacent ones of the first and second plurality of conductive vias is formed on a first surface (106) of the ceramic substrate. Further, a second plurality of conductive traces (110) forming an electrical connection between circumferentially offset ones of the first and second plurality of conductive vias is formed on a second surface of the ceramic substrate opposed from the first surface to define a three dimensional toroidal coil.

Abstract: Embedded capacitors and a method for manufacturing the embedded capacitors. The method can include the steps of forming at least one bore (115) in a dielectric substrate (100). The dielectric substrate can be mechanically punched or laser cut to form the bore. The bore can be filled with a conductive material (250) to form a first electrode (470). A conductor (360) can be formed on the dielectric substrate, the conductor not being electrically continuous with the first electrode. A depth and/or cross sectional area of the bore can be selected to provide a desired amount of capacitive coupling between the electrode and the conductor. At least a second bore can be formed in the dielectric substrate and filled with a conductive material to form a second electrode. The second electrode can be electrically connected to the first electrode.

Abstract: Method for forming a transformer (118) in a ceramic substrate. The method can include the steps of forming at least one conductive coil (119a, 119b) comprising a plurality of turns about an unfired ceramic toroidal core region (120a, 120b) defined within an unfired ceramic substrate (100). The method can also include the step of co-firing the unfired ceramic toroidal core region (120a, 120b), the unfired ceramic substrate (100), and the conductive coil (119a, 119b) to form an integral ceramic substrate structure with the conductive coil at least partially embedded therein.

Abstract: A method for making an embedded toroidal inductor (118) includes forming in a ceramic substrate (100) a first plurality of conductive vias (102) radially spaced a first distance from a central axis (101) so as to define an inner circumference. A second plurality of conductive vias (104) is formed radially spaced a second distance about the central axis so as to define an outer circumference. A first plurality of conductive traces (110) forming an electrical connection between substantially adjacent ones of the first and second plurality of conductive vias is formed on a first surface (106) of the ceramic substrate. Further, a second plurality of conductive traces (110) forming an electrical connection between circumferentially offset ones of the first and second plurality of conductive vias is formed on a second surface of the ceramic substrate opposed from the first surface to define a three dimensional toroidal coil.

Abstract: A method for making an embedded toroidal inductor (118) includes forming in a ceramic substrate (100) a first plurality of conductive vias (102) radially spaced a first distance from a central axis (101) so as to define an inner circumference. A second plurality of conductive vias (104) is formed radially spaced a second distance about the central axis so as to define an outer circumference. A first plurality of conductive traces (110) forming an electrical connection between substantially adjacent ones of the first and second plurality of conductive vias is formed on a first surface (106) of the ceramic substrate. Further, a second plurality of conductive traces (110) forming an electrical connection between circumferentially offset ones of the first and second plurality of conductive vias is formed on a second surface of the ceramic substrate opposed from the first surface to define a three dimensional toroidal coil.

Abstract: There is disclosed a method for stitching, comprising penetrating a material to be stitched, delivering through the penetration an anchor, securing a first end of a thread by the anchor in the penetration, penetrating the material in a position spaced from the first penetration, delivering through the second penetration a second anchor, attaching the thread through the second penetration by the second anchor to the material, repeating the procedure as often as required until a final penetration, at which a final anchor is delivered and a second end of the thread secured by the final anchor thereto.

Abstract: This application is concerned with a messenger ribonucleic acid (mRNA) binding motif. It is particularly concerned with a mRNA binding motif that is capable of binding and destabilizing the mRNA. This provides for an mRNA binding motif having: a) a nucleotide sequence as shown in SEQ ID NO:1; or b) a biologically active fragment of the sequence in a); or c) a nucleic acid molecule which has at least 75% sequence homology to the sequences in a) or b); or d) a nucleic acid molecule which is capable of hybridizing to any one of the sequences in a) or b) under stringent conditions.

Abstract: A system and method for communicating with a device over an external transmission medium. The system may include a host computer system, including a user application, a serial bus interface driver, and a first portion of an interface driver. The host computer may include a serial bus host controller. A serial bus may couple the serial bus host controller to a serial bus interface, which may include an interface connector adapted to couple to the device, wherein the serial bus interface may be operable to store and execute a second portion of the interface driver. When the user application generates an API function call, the first portion of the interface driver may generate a frame of interface commands that are transferred to the second portion of the interface driver for execution, thereby causing signals to be transmitted over an interface bus to the device.

Abstract: A system and method for transferring data over a communications medium. A host is coupled to a device through a serial bus lacking error handling capabilities, such as an IEEE 1394 bus. The host may control the device by sending requests accessing its memory registers. The host generates a first request to the device to access a memory address location of the device, and which includes an address and status information indicating whether a prior request to the memory address location returned successfully. The device examines the status information to determine if it is a retry of a prior request, and if so, determines if the prior request completed successfully to the memory address location by comparing the address and data transfer size of the first request to those of the prior request. If identical, then the prior request completed successfully to the memory address location, and the request is ignored. Otherwise, the device retries the prior request.

Abstract: A system and method for GPIB autopolling of GPIB devices. A computer is coupled to one or more GPIB instruments through a GPIB to analyze, measure or control a process or unit under test. The computer includes a GPIB controller which monitors activity of the GPIB devices on the bus and produces heuristic information regarding the past behavior of the GPIB devices, such as a queue of one or more GPIB device IDs sorted by how recently each device was accessed. The heuristic information produced is stored on a memory and/or hard drive of the computer. A service request (SRQ) line assertion triggered by one or more GPIB devices may be received. The GPIB controller performs autopolling on the GPIB devices as ordered in the queue to determine which of the devices asserted the SRQ. If no queued devices asserted, the remainder of the devices are polled in arbitrary order.

Abstract: The invention relates to methods of treatment of non insulin dependent diabetes mellitus, antagonists of the delayed rectifier potassium channel Kv2.1, methods of using and preparing the antagonists and assays for identifying such antagonists.

Abstract: A system and method for providing web server capabilities for existing instruments without inherent networking capabilities. A server device may comprise an instrument server. The instrument server may communicate with instruments connected to the server device via an instrumentation bus. The instrument server may detect the instruments connected to the instrumentation bus. A client system may connect to the instrument server via a network (e.g. the Internet). The instrument server may provide a graphical user interface to the client system to allow the instruments to be selected, controlled and/or monitored remotely from the client system via the network. In one embodiment, the client system comprises a web browser, and the interface comprises one or more web pages for controlling instruments and for displaying data received from the instruments.

Abstract: A system and method for GPIB autopolling of GPIB devices. A computer is coupled to one or more GPIB instruments through a GPIB to analyze, measure or control a process or unit under test. The computer includes a GPIB controller which monitors activity of the GPIB devices on the bus and produces heuristic information regarding the past behavior of the GPIB devices, such as a queue of one or more GPIB device IDs sorted by how recently each device was accessed. The heuristic information produced is stored on a memory and/or hard drive of the computer. A service request (SRQ) line assertion triggered by one or more GPIB devices may be received. The GPIB controller performs autopolling on the GPIB devices as ordered in the queue to determine which of the devices asserted the SRQ. If no queued devices asserted, the remainder of the devices are polled in arbitrary order.