Abstract: In network security systems, graph-based techniques may be employed to generate “thumbprints” of security incidents, which may thereafter be used, e.g., for threat actor attribution or the identification of similar incidents. In various embodiments, each security incident is represented by a graph in which security events correspond to nodes, and which encodes associated metadata in additional nodes and/or node/edge attributes. Graph representation learning may be used to compute node and/or edge embeddings, which can then be aggregated into the thumbprint of the incident.

Abstract: In network security systems, graph-based techniques can be used to identify, for any given security incident including a collection of security events, other incidents that are similar. In example embodiments, similarity is determined based on graph representations of the incidents in which security events are represented as nodes, using graph matching techniques or incident thumbprints computed from node embeddings. The identified similar incidents can provide context to inform threat assessment and the selection of appropriate mitigating actions.

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an indolinone structure which function as inhibitors of GRK5, and their use as therapeutics for the treatment of heart conditions and cancer.

Abstract: In certain aspects, the present disclosure is related to devices, methods, systems and/or computer-readable media for use in an isochronous media network in which media devices connected to a network employ one or more synchronization signal to regulate or facilitate the transmission of media signals through the network. In certain aspects, the present disclosure is also related to devices, methods, systems and/or computer-readable media for use in a larger unified, or substantially unified, isochronous network created from aggregating local isochronous media networks in which media devices connected to a network employ a one or more synchronisation signal distributed from a local master clock to regulate or facilitate the transmission of media signals.

Abstract: The present disclosure relates to agents, compositions, and methods for inhibiting corrosion in various substrates, for example in metal substrates. The present disclosure also relates to compositions for inhibiting corrosion comprising at least one organic heterocyclic compound and at least one metal salt or mixed metal salt selected from rare earth, alkali earth and transition metals.

Abstract: Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: An ocular implant (10) for conveying intraocular fluid away from a site of excess intraocular fluid within a patient, the implant (10) including: a body (12) including one or more drainage channels (20) each having an outlet (24) fluidly communicable with drainage site located away from the site of excess intraocular fluid; and an elongated tubular member (30) fluidly communicable with the body (12), the member (30) having a first end portion (32) providing an inlet (38), a second end portion (34) providing an end (40), and a lumen extending between the inlet (38) and the end (40), wherein the inlet (38) is fluidly communicable with the site of excess intraocular fluid so that the intraocular fluid is able to flow past the inlet (38) and through the lumen towards the end (40), and wherein the second end portion (34) includes one or more openings (42) each fluidly communicable with a respective one of the one or more drainage channels (20) to permit the intraocular fluid to flow from the second end portion (34

Abstract: The present disclosure is directed to processes, compositions and agents for inhibiting corrosion in various substrates, for example metal substrates. The present disclosure is also directed to corrosion inhibitors comprising organometallic polymers such as metal-organic frameworks (MOFs), including compositions and processes comprising MOFs for inhibiting corrosion in metal substrates.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.

Abstract: A valve assembly includes multiple valves operatively connected with a single valve actuator operable to control and restrict the corresponding positions of each of the multiple valves.

Abstract: The present disclosure relates to agents, compositions, and methods for inhibiting corrosion in various substrates, for example in metal substrates. The present disclosure also relates to compositions for inhibiting corrosion comprising at least one organic heterocyclic compound and at least one metal salt or mixed metal salt selected from rare earth, alkali earth and transition metals.

Abstract: Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: A toaster (103) having a side wall (10) with a reflective surface (16) to reflect radiant heat towards a toasting chamber (13), and an external surface to which there is attached a sensor assembly (12). The sensor assembly (12) provides a source beam to illuminate part of the product and receives a reflected beam that is received by a sensor, with the sensor providing a signal indicative of a property of the reflected beam and therefore a chromatic property of the product.

Abstract: A modular fork assembly for a pallet truck includes a discrete elongate body, a discrete load wheel module, and a discrete fork tip that may be detachably connected by the same or different types of interlocking mechanisms that are adapted to inhibit sheer forces. The load wheel module includes a frame and a load wheel assembly that includes a load wheel that is operatively connected to the frame.

Abstract: A housing for a hydraulic actuator unit of a pallet truck is disclosed. The housing includes a lift motor mount for mounting a lift motor to the housing and a pump mount for mounting a hydraulic pump to the housing, and couples the pump to the lift motor when each are mounted. The housing includes a hydraulic cylinder with a cylinder rod, which is positioned based on the fluid level in the hydraulic cylinder; a reservoir to store fluid for actuation of the cylinder rod; and one or more fluid galleries that extend, internal to the housing, among the fluid reservoir, the pump mount, and the hydraulic cylinder. A traction motor mount mounts the traction motor, which is coupled to a steering unit of the pallet truck and controls actuation of a traction wheel of the pallet truck when the traction motor is mounted to the traction motor mount.

Abstract: This invention concerns the transmitting and receiving of digital media packets, such as audio and video channels and lighting instructions. In particular, the invention concerns the transmitting and receiving of redundant media packet streams. Samples are extracted from a first and second media packet stream. The extracted samples are written to a buffer based on the output time of each sample. Extracted samples having the same output in time are written to the same location in the buffer. Both media packet streams are simply processed all the way to the bugger without any particular knowledge that one of the packet streams is actually redundant. This simplifies the management of the redundant packet streams, such as eliminating the need for a “fail-over” switch and the concept of an “active stream”, the location is the storage space allocated to store one sample.

Abstract: A temperature sensing assembly for a milk frothing apparatus. The assembly including: a temperature sensor element and a resilient support element that receives and biases the temperature sensor element towards thermal communication with the underside of a vessel; wherein the assembly is located towards the end of a protruding portion that extends from the body of the a milk frothing apparatus; and wherein an upper surface of the temperature sensor assembly is adapted to promote liquid movement into a drip tray reservoir. The apparatus may include: a steam source; an air source coupled to an air injector module for mixing the air and steam; a user interface for receiving input from a user; and wherein the apparatus is configurable by receiving input parameters through the user interface, whereby the parameters includes final milk temperature, and an indication of froth amount.

Abstract: A method of regio-selectively synthesizing an imidazo-pyrimidine compound of formulae (XXa) or (XXb) comprising a step of coupling a first compound of formula XX-P1a or XX-P1b with a second compound of formula XX-P2 This annulation reaction between ?-ethoxy acrylamides and phosphorylated aminoimidazoles to furnish imidazo[1,2-a]pyrimidin-amines relies on steering effects from endocyclic and exocyclic phosphorylated aminoimidazoles. The reaction furnishes either 2-amino or 4-amino constitutional isomers of imidazo[1,2-a]pyrimidines with good yields and ranges of 90:10-99:1 regio-selectivity. The reaction is useful in the synthesis of various tracer molecules used in the study of neurological conditions such as where R3 and R4 together with the imidazole ring atoms to which they are bonded form a phenyl ring and the products are substituted benzimidazopyrimidines.

Abstract: A temperature sensing assembly for a milk frothing apparatus. The assembly including: a temperature sensor element and a resilient support element that receives and biases the temperature sensor element towards thermal communication with the underside of a vessel; wherein the assembly is located towards the end of a protruding portion that extends from the body of the a milk frothing apparatus; and wherein an upper surface of the temperature sensor assembly is adapted to promote liquid movement into a drip tray reservoir. The apparatus may include: a steam source; an air source coupled to an air injector module for mixing the air and steam; a user interface for receiving input from a user; and wherein the apparatus is configurable by receiving input parameters through the user interface, whereby the parameters includes final milk temperature, and an indication of froth amount.