Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.

Abstract: A cleaning mechanism of a combine harvester, for cleaning threshed and separated crop material, including a grain pan for receiving threshed and separated crop material and transporting the crop material rearwardly; a chaffer installed proximate the grain pan for receiving material from the grain pan where the chaffer includes a plurality of longitudinal channels with non-planar surfaces giving each channel a curved or trapezoidal cross section and at least two of the chaffer channels have an asymmetric non-planar surface with a greater part of the surface area facing the side portions of the chaffer; and a fan that causes an air flow through the chaffer to lift up discardable parts from the crop material and transport the discardable parts out of the combine harvester.

Abstract: Processes, compositions and agents are included for inhibiting corrosion in various substrates, for example metal substrates. Corrosion inhibitors include organometallic polymers such as metal-organic frameworks (MOFs), including compositions and processes comprising MOFs for inhibiting corrosion in metal substrates. In some aspects, a method of protecting a substrate from corrosion includes applying a protective composition including a corrosion inhibitor to the surface of a substrate, where the corrosion inhibitor includes a metal organic framework (MOF).

Abstract: This invention concerns the transmitting and receiving of digital media packets, such as audio and video channels and lighting instructions. In particular, the invention concerns the transmitting and receiving of redundant media packet streams. Samples are extracted from a first and second media packet stream. The extracted samples are written to a buffer based on the output time of each sample. Extracted samples having the same output time are written to the same location in the buffer. Both media packet streams are simply processed all the way to the buffer without any particular knowledge that one of the packet streams is actually redundant. This simplifies the management of the redundant packet streams, such as eliminating the need for a “fail-over” switch and the concept of an “active stream”, The location is the storage space allocated to store one sample.

Abstract: Disclosed herein are small molecule inhibitors of 12(S)-Lipoxygenase (12-LOX), and methods of using the small molecules to inhibit 12-LOX activation and to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: An application server may receive, from a computing device, transaction information relating to a transaction to be completed at a location, with the transaction information including a first identifier of the location. The application server may also receive, from a mobile device, a request for information relating to the transaction, with the request including a second identifier of the location. The application server may determine an association between the transaction information and the request based on the first identifier and the second identifier. Based on the determined association and responsive to the request, the application server may transmit, to the mobile device, at least part of the transaction information. The application server may receive, from the mobile device, an instruction to complete the transaction and, responsive to receiving the instruction, attempt completion of the transaction using the transaction information and transaction credentials associated with the mobile device.

Abstract: Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: The present disclosure is related to transmitting and receiving media channels, such as audio and video channels. These channels may be transmitted as packets from one or more transmitting devices to one or more receiving devices for playout. Certain embodiments of the present disclosure include systems, methods, and computer-readable media for determining latency of a data network for synchronised playout of received signals. Additionally, certain embodiments of the present disclosure include systems, methods, and computer-readable media for synchronising playout among devices connected to a data network.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.

Abstract: Disclosed is a hazard detection system having: a visual alarm device (VAD) including a VAD controller which is an electronic controller, the VAD controller controlling a plurality of implements within the VAD including a light source, and a luminosity sensor with which the VAD controller is configured to perform a VAD health test to confirm that a plurality of parameters of the light source meet or exceed threshold requirements, the plurality of parameters including luminous intensity and luminous profile, wherein the VAD is configured to perform steps including: monitoring for a trigger event to perform the VAD health test, the trigger event including the occurrence of an alarm a condition; activating the light source upon determining that the trigger event has occurred; monitoring the plurality of parameters to determine whether the light source meets or exceeds threshold requirements, and communicating an outcome of the VAD health test.

Abstract: A method of synthesizing comprising a step of making an imidazo-pyrimidine compound by coupling a first compound of formula (II) with a second compound of formula (III) Followed by a deprotection and tosylation step. The methods are able to produce an isotopically substituted molecule having upwards of 95% purity relative to non-isotopically substituted molecules.

Abstract: 12(S)-hydroxyeicosatrienoic acid (12(S)-HETrE) compounds and compositions comprising the same are disclosed. Methods of using the compounds in the prevention and treatment of thrombosis and thrombotic disorders are also disclosed.

Abstract: Disclosed is a hazard detection system having: a visual alarm device (VAD) including a VAD controller which is an electronic controller, the VAD controller controlling a plurality of implements within the VAD including a light source, and a luminosity sensor with which the VAD controller is configured to perform a VAD health test to confirm that a plurality of parameters of the light source meet or exceed threshold requirements, the plurality of parameters including luminous intensity and luminous profile, wherein the VAD is configured to perform steps including: monitoring for a trigger event to perform the VAD health test, the trigger event including the occurrence of an alarm a condition; activating the light source upon determining that the trigger event has occurred; monitoring the plurality of parameters to determine whether the light source meets or exceeds threshold requirements, and communicating an outcome of the VAD health test.

Abstract: The present disclosure is related to transmitting and receiving media channels, such as audio and video channels. These channels may be transmitted as packets from one or more transmitting devices to one or more receiving devices for playout. Certain embodiments of the present disclosure include systems, methods, and computer-readable media for determining latency of a data network for synchronised playout of received signals. Additionally, certain embodiments of the present disclosure include systems, methods, and computer-readable media for synchronising playout among devices connected to a data network.

Abstract: Disclosed herein are small molecule inhibitors of 12(S)-Lipoxygenase (12-LOX), and methods of using the small molecules to inhibit 12-LOX activation and to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: A load wheel assembly for an elongate fork of a forked material-handling vehicle with a chassis employs a forward load wheel, a rear load wheel, and means for coupling torque between the forward load wheel and the rear load wheel to overcome obstacles on a surface, such as a floor.

Abstract: The present disclosure relates to agents, compositions, and methods for inhibiting corrosion in various substrates, for example in metal substrates. The present disclosure also relates to compositions for inhibiting corrosion comprising at least one organic heterocyclic compound and at least one metal salt or mixed metal salt selected from rare earth, alkali earth and transition metals.

Abstract: This invention concerns the transmitting and receiving of digital media packets, such as audio and video channels and lighting instructions. The network (104) is comprised of at least a transmitter device (110) and a receiving device (112). The controllers (122) and (126) of these devices handle the exchanging of configuration messages between the devices (110) and (112). Using the invention, the user is not required to manually configure the processor to receive media packet streams. Instead, a controller (126) of a receiving device (112) operates to receive information on a user selection of media channels and automatically configure the processor of the transmitter device. Further, the receiving device (112) is able to receive media channels using both unicast and multicast protocols. Media channels can be given textual labels which are unique on the unique (104) and easily identify to the user the actual source of the media channel.

Abstract: A housing for a hydraulic actuator unit of a pallet truck is disclosed. The housing includes a lift motor mount for mounting a lift motor to the housing and a pump mount for mounting a hydraulic pump to the housing, and couples the pump to the lift motor when each are mounted. The housing includes a hydraulic cylinder with a cylinder rod, which is positioned based on the fluid level in the hydraulic cylinder; a reservoir to store fluid for actuation of the cylinder rod; and one or more fluid galleries that extend, internal to the housing, among the fluid reservoir, the pump mount, and the hydraulic cylinder. A traction motor mount mounts the traction motor, which is coupled to a steering unit of the pallet truck and controls actuation of a traction wheel of the pallet truck when the traction motor is mounted to the traction motor mount.