Patents by Inventor Anthony Robinson
Anthony Robinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200369366Abstract: Aircraft nacelles having adjustable chines are described. An example apparatus includes a multi-segment chine coupled to a nacelle. The multi-segment chine includes a first segment and a second segment. The first segment is oriented along a fore-aft direction. The first segment is translatable relative to the nacelle along the fore-aft direction. The first segment includes one or more first airflow openings. The second segment is fixedly coupled to the nacelle. The second segment is oriented along the fore-aft direction. The second segment includes one or more second airflow openings. The second segment is substantially coplanar with the first segment. Translation of the first segment adjusts the transverse alignment of the first airflow openings with the second airflow openings to vary an allowable airflow through the multi-segment chine.Type: ApplicationFiled: May 20, 2019Publication date: November 26, 2020Inventors: Daniel Joseph Goering, Adam M. Clark, Connie Phung, Miles Anthony Robinson, Paul M. Vijgen
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Patent number: 10787486Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.Type: GrantFiled: November 14, 2018Date of Patent: September 29, 2020Assignees: UNIVERSITAET ZUERICH, POLYPHOR LTD.Inventors: Daniel Obrecht, Frank Gombert, Steven J. Demarco, Christian Ludin, Jan Wim Vrijbloed, Kerstin Moehle, John-Anthony Robinson, Reshmi Mukherjee, Heiko Henze, Barbara Romagnoli
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Patent number: 10730911Abstract: Novel backbone-cyclized peptidomimetics of the general formula cyclo[-P1-P2-P3-P4-P5-P6-P7-P8-T1-T2-]?? (I) wherein the single elements T or P are ?-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to modulate the GLP-1 receptor. They can be used as medicaments to treat, prevent, or delay the onset of diseases, disorders or conditions in which modulation of the human GLP-1 receptor is beneficial, such as type 2 diabetes. These backbone-cyclized peptidomimetics can be manufactured by a process which is based on a mixed solid—and solution phase synthetic strategy.Type: GrantFiled: April 6, 2016Date of Patent: August 4, 2020Assignees: UNIVERSITAT ZURICH, POLYPHOR AGInventors: Daniel Obrecht, Christian Bisang, Anatol Luther, Steffen Weinbrenner, John Anthony Robinson, Kerstin Moehle, Christian Steuer, William J. Drury, III
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Patent number: 10730912Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: December 28, 2016Date of Patent: August 4, 2020Assignees: POLYPHOR LTD., UNIVERSITAET ZUERICHInventors: Steven J. Demarco, Wim Vrijbloed, Ricardo Dias, John Anthony Robinson, Nityakalyani Srinivas, Frank Gombert, Daniel Obrecht
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Publication number: 20190257558Abstract: A hot water energy storage system (100) comprises a storage vessel (102); a pump (151); a heat exchanger (152) arranged to receive water from the storage vessel (102) and to output water to the storage vessel (102); a diverting valve (158) to divert a proportion of the water output from the heat exchanger (152) back to an inlet of the heat exchanger (152), bypassing the storage vessel (102); a temperature sensor (120a-c) to measure a temperature of water within the system (100); and a control system (130). The control system (130) controls the pump (151) and the diverting valve (158), based on a temperature measurement of the water and the desired quantity of heat to be transferred by the heat exchanger (152), so as to maintain the return temperature of water entering the storage vessel (102) within a specified range whilst transferring the desired quantity of heat.Type: ApplicationFiled: November 2, 2017Publication date: August 22, 2019Applicant: ESG POOL VENTILATION LIMITEDInventor: Anthony Robinson
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Publication number: 20190100558Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysll, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activityType: ApplicationFiled: November 14, 2018Publication date: April 4, 2019Applicants: UNIVERSITAET ZUERICH, POL YPHOR LTD.Inventors: Daniel OBRECHT, Frank GOMBERT, Steven J. DEMARCO, Christian LUDIN, Jan Wim VBIJBLOED, Kerstin MOEHLE, John-Anthony ROBINSON, Reshmi MUKHERJEE, Heiko HENZE, Barbara ROMAGNOLI
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Patent number: 10208966Abstract: A method of and system for heating and/or cooling a fluid, the method comprising moving the fluid through a secondary side of a heat exchanger and controlling the temperature of a primary side of the heat exchanger such that the temperature of the primary side of the heat exchanger is maintained substantially at a determined temperature interval from a reference temperature which is a function of at least one of: a temperature of an inlet to the secondary side and a temperature of an outlet of the secondary side.Type: GrantFiled: April 10, 2015Date of Patent: February 19, 2019Assignee: ESG POOL VENTILATION LIMITEDInventor: Anthony Robinson
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Patent number: 10144765Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.Type: GrantFiled: December 21, 2017Date of Patent: December 4, 2018Assignees: POLYPHOR LTD., UNIVERSITAET ZUERICHInventors: Daniel Obrecht, Frank Gombert, Steven J. Demarco, Christian Ludin, Jan Wim Vrijbloed, Kerstin Moehle, John-Anthony Robinson, Reshmi Mukherjee, Heiko Henze, Barbara Romagnoli
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Publication number: 20180256698Abstract: The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.Type: ApplicationFiled: February 28, 2018Publication date: September 13, 2018Inventors: Arin Ghasparian, Armando Zuniga, Nina Geib, Marco Tamborrini, Maja Jud, Gerd Pluschke, Aniebrys Marrero Nodarse, John Anthony Robinson
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Publication number: 20180127467Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activityType: ApplicationFiled: December 21, 2017Publication date: May 10, 2018Applicants: UNIVERSITAET ZUERICH, POLYPHOR LTD.Inventors: Daniel Obrecht, Frank Gombert, Steven J. Demarco, Christian Ludin, Jan Wim Vrijbloed, Kerstin Moehle, John-Anthony Robinson, Reshmi Mukherjee, Heiko Henze, Barbara Romagnoli
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Publication number: 20180123680Abstract: A spaced-based system is provided to simultaneously track and monitor one or more ocean going vessels at any point on the earth. The system includes a plurality of space vehicles or satellites each satellite includes an AIS communications payload to receive AIS signals including AIS information transmitted from the one or more vessels and to transmit the received AIS information. The system also includes a plurality of ground earth elements. Each ground earth element includes a receiver to receive the AIS information transmitted from one or more of the plurality of satellites to globally track and monitor the one or more vessels based on the AIS information received from the communications payload. The plurality of satellites are distributed in two or more orbital planes located at a substantially common altitude and having a substantially common inclination. In particular, the satellites may be deployed in a low earth orbit constellation.Type: ApplicationFiled: October 20, 2017Publication date: May 3, 2018Inventors: John Stolte, Anthony Robinson, Anthony Hopko
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Patent number: 9943583Abstract: The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.Type: GrantFiled: December 2, 2014Date of Patent: April 17, 2018Assignees: UNIVERSITÄT ZÜRICH, SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE, VIROMETIX AGInventors: Arin Ghasparian, Armando Zuniga, Nina Geib, Marco Tamborini, Maja Jud, Gerd Pluschke, Aniebrys Marrero Nodarse, John Anthony Robinson
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Publication number: 20180072774Abstract: Novel backbone-cyclized peptidomimetics of the general formula cyclo[-P1-P2-P3-P4-P5-P6-P7-P8-T1-T2-]?? (I) wherein the single elements T or P are ?-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to modulate the GLP-1 receptor. They can be used as medicaments to treat, prevent, or delay the onset of diseases, disorders or conditions in which modulation of the human GLP-1 receptor is beneficial, such as type 2 diabetes. These backbone-cyclized peptidomimetics can be manufactured by a process which is based on a mixed solid—and solution phase synthetic strategy.Type: ApplicationFiled: April 6, 2016Publication date: March 15, 2018Inventors: Daniel OBRECHT, Christian BISANG, Anatol LUTHER, Steffen WEINBRENNER, John Anthony ROBINSON, Kerstin MOEHLE, Christian STEUER, William J. DRURY, III
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Patent number: 9879047Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.Type: GrantFiled: December 15, 2016Date of Patent: January 30, 2018Assignees: POLYPHOR LTD., UNIVERSITAET ZUERICHInventors: Daniel Obrecht, Frank Gombert, Steven J. Demarco, Christian Ludin, Jan Wim Vrijbloed, Kerstin Moehle, John-Anthony Robinson, Reshmi Mukherjee, Heiko Henze, Barbara Romagnoli
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Publication number: 20170369523Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 8 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have agonizing or antagonizing activity against urotensin II or show inhibition of the STAT6/NCoA-1 interaction and can be used for preventing or treating diseases or disorders related to urotensin II, STAT6 and NCoA-1. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Applicant: POLYPHOR AGInventors: John Anthony ROBINSON, Kerstin MÖHLE, Markus SEITZ, Ludovic T. MAILLARD, Roba MOUNME, Frank Otto GOMBERT, Odile SELLIER-KESSLER, Heiko HENZE, Daniel OBRECHT, Christian BISANG, Alexander LEDERER
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Publication number: 20170107259Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid and solution phase synthetic strategy.Type: ApplicationFiled: December 28, 2016Publication date: April 20, 2017Applicants: POLYPHOR LTD., UNIVERSITAET ZUERICHInventors: Steven J. DEMARCO, Wim VRIJBLOED, Ricardo DIAS, John Anthony ROBINSON, Nityakalyani SRINIVAS, Frank GOMBERT, Daniel OBRECHT
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Publication number: 20170096453Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activityType: ApplicationFiled: December 15, 2016Publication date: April 6, 2017Applicants: UNIVERSITAET ZUERICH, POLYPHOR LTD.Inventors: Daniel OBRECHT, Frank GOMBERT, Steven J. DEMARCO, Christian LUDIN, Jan Wim VRIJBLOED, Kerstin MOEHLE, John-Anthony ROBINSON, Reshmi MUKHERJEE, Heiko HENZE, Barbara ROMAGNOLI
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Patent number: 9596852Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: February 7, 2014Date of Patent: March 21, 2017Assignees: POLYPHOR LTD., UNIVERSITAET ZUERICHInventors: Steven J. Demarco, Wim Vrijbloed, Ricardo Dias, John Anthony Robinson, Nityakalyani Srinivas, Frank Gombert, Daniel Obrecht
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Patent number: 9556234Abstract: The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.Type: GrantFiled: November 28, 2014Date of Patent: January 31, 2017Assignees: Polyphor Ltd., Universitaet ZuerichInventors: Daniel Obrecht, Frank Gombert, Steven J. Demarco, Christian Ludin, Jan Wim Vrijbloed, Kerstin Moehle, John-Anthony Robinson, Reshmi Mukherjee, Heiko Henze, Barbara Romagnoli
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Patent number: D789220Type: GrantFiled: August 15, 2016Date of Patent: June 13, 2017Assignee: Park 'N Fly Service LLCInventors: Michael David Deaderick, Anthony L Paalz, Jr., William Dutch Millard, Michael Anthony Robinson