Abstract: The template-fixed ?-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or for treating inflammation, or, in particular, for stem cell mobilization of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor.

Abstract: Systems and methods for monitoring over-the-top adaptive video streaming in a network are described. In an embodiment, a method may include identifying a protocol used in the communication based, wherein the protocol may be one among a plurality of different adaptive video streaming protocols. Video sessions using a plurality of different protocols are monitored and video session data collected. User Quality of Experience (QoE) and Key QoE Indicators (KQI) are generated for the network. Network operators may access video session data to analyze initial buffering delays, rebuffering delays, bandwidth changes, and gaps during the video session.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or during apheresis collections of peripheral blood stem cells. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 8 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have agonizing or antagonizing activity against urotensin II or show inhibition of the STAT6/NCoA-1 interaction and can be used for preventing or treating diseases or disorders related to urotensin II, STAT6 and NCoA-1. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly or Pro, or of certain types, at least one of these residues being of the type of N-substituted glycines, which types, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit the growth of or to kill microorganisms. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials or as medicaments to treat or prevent infections. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

Abstract: Template-fixed ?-hairpin peptidomimetics of the General Formula (I); wherein Z1 and Z2 are template-fixed chains of 4 and 6 or 5 and 7 ?-amino acid residues and salts thereof. They have CXCR4-antagonizing properties and can be used as medicaments. These ?-sheet peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Abstract: An automatic identification system (AIS) communications payload for a space vehicle traveling in earth orbit includes an antenna; a receiver connected to the antenna to receive an AIS signal including a reported vessel position transmitted from a vessel; a processor to process the received AIS messages and determine the accuracy of the reported vessel position; and a transmitter to transmit the processed AIS messages and the determined accuracy to a ground earth element. The processor may be configured to determine a position of the space vehicle; compare the reported vessel position to the space vehicle position; and determine the accuracy of the reported vessel position based on the comparison. The processor also may be configured to flag the AIS message as suspect when the reported vessel position is determined to be inaccurate.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining Symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and Solution phase synthetic strategy.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid—and solution phase synthetic strategy.

Abstract: A medicine bottle for reminding a patient to take a dosage of medicine at a prescribed time includes a disposable bottle and a corresponding disposable cap. The system further includes a mechanism for recording and playing back instructions to take the medicine dosage at the prescribed time and an amplifier electrically coupled directly to the audio recording and playback device, and a transducer electrically coupled to the amplifier. A mechanism is further included for selectively unlocking the lock actuator from a locked position when a present time is within a predetermined number of hours of the prescribed time.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 ?-amino acid residues which, depend on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa and Acinetobacter. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. In a specific embodiment, the template is based on the D-Pro-L-Pro dipeptides. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid—and solution phase synthetic strategy.

Abstract: The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where Cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or, in particular, for stem cell mobilisation of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and Solution phase synthetic strategy, using methods which are well known to those adequately skilled in peptide chemistry.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 ?-amino acid residues which, depend on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa and Acinetobacter. They can be used as disinfectants for foodstuff, cosmetics, medicaments or other nutrient-containing materials, or as medicaments or treat or prevent infections. In a specific embodiment, the template is based on the D-Pro-L-Pro dipeptide. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formulae (I), wherein Z is a template-fixed chain of 7 to 11 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Abstract: An automatic identification system (AIS) communications payload for a space vehicle traveling in earth orbit includes an antenna; a receiver connected to the antenna to receive an AIS signal including a reported vessel position transmitted from a vessel; a processor to process the received AIS messages and determine the accuracy of the reported vessel position; and a transmitter to transmit the processed AIS messages and the determined accuracy to a ground earth element. The processor may be configured to determine a position of the space vehicle; compare the reported vessel position to the space vehicle position; and determine the accuracy of the reported vessel position based on the comparison. The processor also may be configured to flag the AIS message as suspect when the reported vessel position is determined to be inaccurate.

Abstract: A spaced-based system is provided to simultaneously track and monitor one or more ocean going vessels at any point on the earth. The system includes a plurality of space vehicles or satellites. Each satellite includes an AIS communications payload to receive AIS signals including AIS information transmitted from the one or more vessels and to transmit the received AIS information. The system also includes a plurality of ground earth elements. Each ground earth element includes a receiver to receive the AIS information transmitted from one or more of the plurality of satellites to globally track and monitor the one or more vessels based on the AIS information received from the communications payload. The plurality of satellites are distributed in two or more orbital planes located at a substantially common altitude and having a substantially common inclination. In particular, the satellites may be deployed in a low earth orbit constellation.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formulae (I) and (II) wherein Z, Z1 and Z2 are template-fixed chains of 8 to 16 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have the property to inhibit the growth of or to kill microorganisms and cancer cells. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials or as medicaments to treat or prevent infections or diseases related to such infections and/or cancer.

Abstract: A board game device having a plurality of tri-squares, four corners and a diagonally arranged border row of eight tri-squares of a conspicuous hue extending between two corners of the board and dividing the board into two triangular sections, with a plurality of parallel rows with the center row thereof perpendicular to the border row, having a contrasting hue on different sides of the border, with proximal and distal ends thereof forming player positions at the other corner wherein each game piece has at least a tetrahedron first body member.

Abstract: The present invention relates to a clock recovery circuit for generation of a recovered clock signal from a received data stream using a weighted combination of phase component signals. The clock recovery circuit comprises: a detector to detect the phase of a received data stream; a selector comprising a differential generator arranged to generate at least two related signals in dependence on the detected phase; and a clock signal generator to receive the at least two related signals and select related proportions of two or more of a plurality of phase component signals for combination, thereby to generate a recovered clock signal.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formulae (1), wherein Z is a template-fixed chain of 7 to 11 ?-amino acid residues which, depending on their positions in the chain (counted starting formteh N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the aove formulae, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.