Abstract: Embodiments are disclosed for determining scene-based editing recommendations for video content. A method of determining scene-based editing recommendations for video content includes receiving an input video comprising video content, dividing the input video into the plurality of scenes based on the video content, identifying a representative frame for each scene, determining a plurality of editing settings for each representative frame, determining editing settings for each scene based on an effectiveness score, and generating an output video using the input video and the editing settings for each scene.

Abstract: Systems and methods for optimizing and training machine learning (ML) models are provided. In embodiments, a computer implemented method includes: performing, by a processor set, a group execution of ML pipelines using a first subset of a training data set as input data for the ML pipelines, thereby generating a trained ML model for each of the ML pipelines, wherein data transformations that are common between the ML pipelines are implemented only once to generate an output, and the output is shared between the ML pipelines during the group execution of the ML pipelines; generating, by the processor set, performance metrics for each of the trained ML models based on validation data; ranking, by the processor set, the trained ML models based on the performance metrics, thereby generating a list of ranked ML models; and outputting, by the processor set, the list of ranked ML models to a user.

Abstract: An adaptive logic board for a variable speed drive (VSD) of a heating, ventilation, air conditioning, and refrigeration (HVAC&R) system includes a signal sensing circuit configured to receive an input signal from a sensor of the VSD. The signal sensing circuit includes a filter configured to condition the input signal. The filter includes a variable resistance element configured to adjust a cutoff frequency of the filter. The filter is configured to attenuate waveforms in the input signal having frequencies that exceed the cutoff frequency to generate a conditioned signal. The adaptive logic board also includes a controller configured to receive the conditioned signal and to adjust the variable resistance element to adjust the cutoff frequency of the filter based on a parameter of the HVAC&R system.

Abstract: Disclosed embodiments provide techniques for estimating imputation algorithm performance. Multiple imputer algorithms are selected, and an evaluation of how well each of the imputer algorithms can estimate the missing data is performed. Disclosed embodiments obtain an imputer candidate dataset (ICD). The imputer candidate dataset is compared to the incomplete data range, and a similarity metric is determined between the data range and the ICD. When the similarity metric exceeds a predetermined threshold, an imputer evaluation dataset (IED) is created from the ICD by removing one or more data points from the ICD. Each imputer algorithm is evaluated by applying the IED to it, and computing an imputer evaluation metric based on its performance. The multiple imputer algorithms are ranked based on the imputer evaluation metric. The best ranked imputer algorithm can then be selected for use on the incomplete data range within the measurement dataset.

Abstract: Provided are compositions that include compositions of galactosyl-conjugated lipid nanoparticles (LNPs) encapsulating one or more active agents. In some embodiments, the galactosyl-conjugated LNPs have a lipid component having D-Lin-MC3-DMA, ALC-0315 and SM-102, cholesterol. DSPC and DOPE, and DMG-2000-PEG. In some embodiments, the GalNAc-conjugated LNP has one or more galactosyl moieties bioconjugated to cholesterol present with a lipid component of the GalNAc-conjugated LNP. Also provided are methods for treating and/or preventing diseases, disorders, and/or conditions associated with undesirable PCSK9 gene expression, optionally a cardiovascular disease, disorder, or condition, including but not limited to atherosclerosis and/or thrombosis, and sepsis, septic shock, cytokine storm, or sequelae thereof.

Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: Hotel amenity fluid dispensing assemblies, systems, and methods for refilling empty reuseable jars from a source container positioned on separate scales within a housing. Each container/jar provides an RFID tag identity read by its respective scale RFID reader to provide selective operational parameters. Separate housing tower assemblies are fluidly connected to the central pumping assembly between the tower assemblies to draw product from the source container to the fill jar. Microprocessor-based control is electrically coupled to the pumping assembly, the scales, and RFID readers to turn fluid flow on and off. The control actuates the pumping assembly to dispense a precise amount of the fluid based upon the RFID identity and real time scale readings and activates tower assembly manifold movement to allow for replacement of empty source and full fill jars.

Abstract: Exhaustive driving analytical methods, systems, are apparatuses are described. The methods, systems, are apparatuses relate to utilizing partially available data associated with driver and/or driving behaviors to determine safety factors, identify times to react to events, and contextual information regarding the events. The methods, systems, and apparatuses described herein may determine, based on a systematic model, reactions and reaction times, compare the vehicle behavior (or lack thereof) to the modeled reactions and reaction times, and determine safety factors and instructions based on the comparison.

Abstract: The present invention provides ophthalmic compositions, e.g. artificial tears, suitable for treating dry eye syndrome in a human or other mammal suffering there from, e.g. a dog or cat, which comprise a mixture of castor oil with another oil, e.g. a food oil, e. g. olive oil, sesame oil, corn oil etc.

Abstract: A non-transitory, computer readable medium storing instructions that, when executed by a processor, cause the processor to receive, via a graphical user interface (GUI), a first input indicative of a request to generate a storyboard including one or more visualizations associated with operation of one or more industrial automation systems, wherein the request identifies first and second data from one or more data sources, retrieve the first and second data from the one or more data sources, generate a first dataset based on the first data retrieved from the one or more data sources, generate a second dataset based on the first data retrieved from the one or more data sources, and generate for display via the GUI, the storyboard based on the first dataset and the second dataset.

Abstract: A non-transitory, computer readable medium storing instructions that, when executed by a processor, cause the processor to receive, via a graphical user interface (GUI), a first input indicative of a request to generate a storyboard including one or more visualizations associated with operation of one or more industrial automation systems, wherein the request identifies first and second data from one or more data sources, retrieve the first and second data from the one or more data sources, generate a first dataset based on the first data retrieved from the one or more data sources, generate a second dataset based on the first data retrieved from the one or more data sources, and generate for display via the GUI, the storyboard based on the first dataset and the second dataset.

Abstract: This invention relates to methods and compositions for treatment of inv (16) leukemia and particularly to treatment of acute myeloid leukemia. Disclosed is a method of treating inv (16) leukemia comprising the step of administering to a subject in in need thereof a therapeutically effective combination of a) a compound of the formula (1) (1) and b) a BRD4 inhibitor selected from the group consisting of JQ1, CeMMECZ, 1-BET 151 (or GSK1210151A), 1-BET 762 (or GSK525762), PFI-1, bromosporine, OTX-015 (or MK-8628), TEN-010, CPI-203, CPI-0610, RVX-208, BI2536, TG101348, LY294002, ABBV-075 (or mivebresib), FT-1101, ZEN003694, pharmaceutically acceptable salts and mixtures thereof. The therapeutically effective combination synergistically inhibits proliferation of inv (16) leukemia cells. This invention also relates to pharmaceutical compositions comprising a therapeutically effective combination of the compound of formula (1) and the BRD4 inhibitor and a pharmaceutically acceptable excipient.

Abstract: The present disclosure describes systems, non-transitory computer-readable media, and methods for generating object-specific-preset edits to be later applied to other digital images depicting a same object type or applying a previously generated object-specific-preset edit to an object of the same object type within a target digital image. For example, in some cases, the disclosed systems generate an object-specific-preset edit by determining a region of a particular localized edit in an edited digital image, identifying an edited object corresponding to the localized edit, and storing in a digital-image-editing document an object tag for the edited object and instructions for the localized edit. In certain implementations, the disclosed systems further apply such an object-specific-preset edit to a target object in a target digital image by determining transformed-positioning parameters for a localized edit from the object-specific-preset edit to the target object.

Abstract: Various methods and systems are provided for generating and displaying summaries of patient information extracted from one or more medical reports stored in an electronic medical record (EMR) of a patient. In one example, a method includes receiving text data of a patient; entering the text data as input into a plurality of entity recognition models, each entity recognition model of the plurality of entity recognition models trained to label instances of a respective entity in the text data; aggregating the labeled text data outputted by each entity recognition model; generating a summary of the text data based on the aggregated labeled text data; and displaying and/or saving the summary and/or the aggregated labeled text data.

Abstract: In implementations of systems for generating and propagating personal masking edits, a computing device implements a mask system to detect a face of a person depicted in a digital image displayed in a user interface of an application for editing digital content. The mask system determines an identifier for the person based on an identifier for the face. Edit data is received describing properties of an editing operation and a type of mask used to modify a particular portion of the person depicted in the digital image. The mask system edits an additional digital image identified based on the identifier of the person using the type of mask and the properties of the editing operation to modify the particular portion of the person as depicted in the additional digital image.

Abstract: The disclosure provides for resorcinol-based compounds, pharmaceutical compositions made therefrom, and methods of treatment thereof for various disorders, including neoplastic disorders.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof.

Abstract: According to examples, an apparatus includes a processor that is to cause an application to be provided through which information pertaining to a first user is to be displayed, receive authentication information of a second user, in which the authentication information includes an identifier of the second user and information that the second user uses for authentication to access a web-based application, determine whether the identifier of the second user is linked to an identifier of the first user, determine whether the authentication information authenticates the second user to access the web-based application, and based on a determination that the identifier of the second user is linked to the identifier of the first user and the authentication information authenticates the second user to access the web-based application, perm it the second user to access the information pertaining to the first user through the application.

Abstract: Embodiments of the invention are directed to a computer-implemented method. A non-limiting example of the computer-implemented method includes accessing, using a processor system, a process-step sequence that includes a plurality process-steps and a plurality of queue-times. A process-step sequence mining operation is applied to the process-step sequence, wherein the process-step sequence mining operation is operable to make a prediction of an impact of a portion of the process-step sequence on a characteristic of a product generated by the process-step sequence.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.