Abstract: An alternatively spliced intronic sequence is disclosed, the splicing of which can be induced in the presence of a small molecule, e.g., Compound (I), as described herein.

Abstract: A computer system can implement a network transaction service by monitoring location data from a computing device of a user to confirm that the user is located at a merchant location, receiving transaction data from a point-of-sale terminal of the merchant location, and confirming that the user has left the merchant location based on the location data. The computer system may then automatically execute a transfer operation to fund the transaction using a shared funding account of the network transaction service such that no direct payment interaction is made between the user and the merchant.

Abstract: A method carried out by an access management system is described that facilitates modifying a mobile wireless data network services profile for a subscriber. The access management system includes an event manager and a set of trigger event processors configured to process particular trigger event types of trigger event instances received by the access management system. A triggering event message is received that specifies: a triggering event type, and a subscriber identification corresponding to the subscriber. An event notification message, in accordance with the triggering event type, is forwarded to a target node of the set of trigger event processors. An action message is rendered, based on the event notification message. The action message specifies: a prescribed action, and the subscriber identifier. An updated profile configuration is provided for an account for implementation of an access limit placed on digital data services access in accordance with the updated profile configuration.

Abstract: A dispenser has a container and a mounting structure for mounting the container on a wall surface for dispensing a fluid. The container includes a block extending outwardly from a rear surface. The mounting structure has a back surface that is adapted for mounting on the wall surface, and a female receiver that is sized and shaped to receive the block into the female receiver. At least one locking post is movably mounted in the female receiver to move between a locked position wherein the at least one locking post extends outwardly into the female receiver and interlocks with at least one bore of the block, and an unlocked position wherein the at least one locking post are retracted from the locked position to that the block is released. A biasing mechanism biases the at least one locking post towards the locked position.

Abstract: Described herein are methods and compositions for the treatment of ocular conditions and for the improvement of vision parameters using pharmaceutically acceptable ophthalmic pilocarpine formulations. A nonlimiting example of an ocular condition that may be treated with the methods and compositions disclosed herein is presbyopia.

Abstract: Systems and methods for imaging breath-hold (BH)-induced oxygenation changes in a patient are provided. A non-invasive, non-contact device can be used to image BH-induced oxygenation changes in one or more parts (e.g., foot) of a patient. The patient can hold his or her breath for a set amount of time while imaging is performed using the device, and the imaging can be performed before and/or after the time while the patient is holding his or her breath as well (e.g., during a recovery period). This enables tissue oxygenation based flow correlation independent of melanin concentration (e.g., skin color) of the patient and/or the curvature of the tissue (of the patient) being imaged.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: Embodiments of the invention provide optimized polymeric surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These polymer surfaces have a constellation of features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a polymer surface with the disclosed constellation of features.

Abstract: A device for threading and automatically retrieving a suture is provided. The device includes a bottom handle having a channel for receiving and retaining a suture, and a top handle having a needle with an opening, the opening configured to receive and retrieve the suture as the device is moved from a closed position to an open position. Related methods of use are also provided.

Abstract: A method, system, and computer program product that is configured to: receive an input time series from an external device in a first system, divide the input time series to a set of univariate time subseries, transform the set of univariate time subseries into a univariate prediction result series using a transformer model, concatenate the univariate prediction result series to a multivariate predictive result, and output the multivariate predictive result for providing time series forecasting to a second system.

Abstract: A system to control operation of an HVAC unit for conditioning indoor air quality in a multi-zone area is disclosed, The system comprises a controller adapted to be operatively connected to an air handling unit (AHU) associated with the HVAC unit. The controller is configured to receive, from one or more sensors installed at a plurality of zones of an area of interest (AOI), a set of data packets pertaining to indoor air quality (IAQ) at each of the zones in real-time. Further, when the IAQ of any of the plurality of zones is detected to be above a first predefined level, the controller enables the AHU and the HVAC unit to circulate air from at least one of the remaining zones having the IAQ below the first predefined level to the zones having the IAQ above the first predefined level.

Abstract: Systems, devices, and methods for performing peripheral vascular imaging are provided. A continuous wave, non-contact, near-infrared optical scanner (NIROS) can utilize at least one near-infrared (NIR) light. The diffuse reflected NIR signal(s) can be obtained from the surface of the tissue of the mammal being imaged. The signal(s) can be optically filtered and can be detected by an NIR-sensitive image sensor. A graphical user interface (GUI) can be used to automate the acquisition of the spatio-temporal diffuse reflected maps from the NIROS device.

Abstract: The present disclosure relates to an adaptive logic board that includes a signal sensing circuit configured to receive an input signal as an electrical current. The signal sensing circuit includes a plurality of resistors and a plurality of switches configured to electrically couple or electrically decouple the plurality of resistors from the signal sensing circuit, in which each switch of the plurality of switches corresponds to a corresponding resistor of the plurality of resistors. The adaptive logic board also includes a sensing unit that is configured to measure a voltage drop of the input signal across an active resistor of the plurality of resistors.

Abstract: A method of inhibiting KIF15 can include administering a compound to the KIF15 to inhibit biological functionality of KIF15. The compound includes a structure of Formula 1. R1 and R2 are each independently a non-hydrogen substituent, such that the compound inhibits biological functionality of KIF15, or a stereoisomeric form or a mixture of stereoisomeric forms, or pharmaceutically acceptable salts of the compound. The compound is administered to the KIF15 to inhibit KIF15 from interacting with TPX2 so as to inhibit or disrupt a protein-protein interaction therebetween. The administering of the compound can be to a subject having the KIF15, which is administered in a therapeutically effective amount to treat a disease or disorder associated with KIF15 interacting with TPX2, such as treating a cancer or neoplasm.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: An improved information management system that implements a staging area or cache to temporarily store primary data in a native format before the primary data is converted into secondary copies in a secondary format is described herein. For example, the improved information management system can include various media agents that each include one or more high speed drives. When a client computing device provides primary data for conversion into secondary copies, the primary data can initially be stored in the native format in the high speed drive(s). If the client computing device then submits a request for the primary data, the media agent can simply retrieve the primary data from the high speed drive(s) and transmit the primary data to the client computing device. Because the primary data is already in the native format, no conversion operations are performed by the media agent, thereby reducing the restore delay.

Abstract: A computer-implemented method for developing a hierarchical machine-learning pipeline can include receiving a hierarchy specification, a set of estimators for the root node, and one or more transformer options for each of the transformer nodes. The hierarchy specification provides a configuration of the root node, transformer nodes, and edges interconnecting the root and transformer nodes. A rank can be obtained for each estimator in the root node. A hierarchy pipeline traverser can then traverse a first child layer of the transformer nodes connected to the root node via one of the edges. A first ranked list of pathways can be determined with respect to the one or more transformer options selected for the first child layer and at least one selected estimator of the root node.

Abstract: Detecting and mitigating anomalous system behavior by providing a machine learning model comprising a knowledge graph depicting system entity relationships, and modeling behavioral correlations among system entities according to historical time-series data, receiving real-time time-series data for the system, detecting an anomalous system behavior in a system locale, according to the real-time time-series data, according to the machine learning model and multivariate sensor metrics, diagnosing the anomalous system behavior according to an upstream portion of the knowledge graph and a statistical behavior model for the system locale, and mitigating the anomalous behavior by deriving a recommended action according to the anomalous behavior and generating a work order to implement the recommended action.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: A method, system, and computer program product that is configured to: receive at least one change request (CR) for a modification in a cloud environment; predict an outage risk for the at least one CR in the cloud environment using a predictive machine learning model which predicts based on historical data and historical features; and suggest at least one recommendation to mitigate the outage risk for the at least one CR in the cloud environment. In particular, embodiments are based on feature objects (or feature sets) (f, e), which are separation of factors pertaining to the CR and to a predicted environment at a currently scheduled CR execution time, as well as dependencies on the features of other CRs in the queue.