Abstract: An improved information management system that implements a staging area or cache to temporarily store primary data in a native format before the primary data is converted into secondary copies in a secondary format is described herein. For example, the improved information management system can include various media agents that each include one or more high speed drives. When a client computing device provides primary data for conversion into secondary copies, the primary data can initially be stored in the native format in the high speed drive(s). If the client computing device then submits a request for the primary data, the media agent can simply retrieve the primary data from the high speed drive(s) and transmit the primary data to the client computing device. Because the primary data is already in the native format, no conversion operations are performed by the media agent, thereby reducing the restore delay.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: A system and method are provided herein for modeling of force vectors for serial casts to correct orthopedic deformities includes a camera configured to capture a three-dimensional image of the deformity, a computing device programmed to generate a three-dimensional model of the deformity based on the image of the deformity, determine the boundary conditions for the deformity based on the three-dimensional image of the deformity, and generate force vectors for a series of casts to correct the deformity. In exemplary embodiments, the system can print a series of casts to correct the deformity.

Abstract: The present invention provides methods for preparing Favipiravir (6-fluoro-3-hydroxypyrazine-2-carboxamide).

Abstract: A computer-implemented method in accordance with one embodiment includes, in response to a submission of an input dataset to an artificially intelligent application, receiving an explanation from each module of the application. The modules are configured within the application in a serial sequence in which each module, upon receiving the input dataset and any input generated by an immediately preceding module of the serial sequence, generates output that is forwarded as input to a next module, if any, in the sequence. A determination is made that at least two of the received explanations are semantically inconsistent.

Abstract: A farming machine is configured to identify and compensate for occlusions in the field of view of its image acquisition system. To do so, the machine captures an image using a first set of capture parameters associated with a first set of treatment results. The farming machine identifies an occlusion in the first image that obstructs a portion of the first image and determines occlusion characteristics representative of the occlusion based on image data in the first image. The farming machine compensates for the identified occlusion based on the occlusion characteristics. The farming machine captures a second image using modified set of capture parameters that compensate for the occlusion. The second image is associated with a second set of treatment results. The farming machine transmits the second set of treatment results to a manager of the farming machine.

Abstract: In one aspect, described herein is an intronic recognition element for splicing modifier (iREMS) that can be recognized by a compound provided herein. In another aspect, described herein are methods for modulating the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene contains an intronic REMS, and the methods utilizing a compound described herein. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene comprises an intronic REMS, and the methods utilizing a compound described herein. In another aspect, provided herein are artificial gene constructs comprising an intronic REMS, and uses of those artificial gene constructs to modulate protein production.

Abstract: Systems and methods in accordance with aspects of this disclosure may be provided to determine and calculate an overall driving risk index value corresponding to a driver and scene configuration. The overall driving risk index value may provide driving risk modeling and estimation at a personalized driving level. In some cases, the overall driving risk index value may be determined using a risk-predictive modeling system with weighting and machine learning and may include one or more of: a driver score system, a driver-contextual risk score system, and a conflict index system.

Abstract: A system and method are provided herein for modeling of force vectors for serial casts to correct orthopedic deformities includes a camera configured to capture a three-dimensional image of the deformity, a computing device programmed to generate a three-dimensional model of the deformity based on the image of the deformity, determine the boundary conditions for the deformity based on the three-dimensional image of the deformity, and generate force vectors for a series of casts to correct the deformity. In exemplary embodiments, the system can print a series of casts to correct the deformity.

Abstract: A control circuit obtains a first set of rules that define a conveyability range for containers as a function of conveyability constraints pertaining to an intermediary distribution facility. The control circuit also accesses conveyability constraint information for the intermediary distribution facility and generates a conveyability range for that facility by evaluating the constraint information against the first set of rules. The control circuit obtains a second set of rules that define an objective function that uses the conveyability range as a constraint to determine an optimal container pack size for the given item. (By one approach these teachings will also accommodate using at least two additional constraints, such as a so-called days-of-supply (DOS) constraint and a so-called pack-and-a-half constraint.) The control circuit then generates an optimal container pack size for the given item by evaluating the objective function against the conveyability range (and other selected constraints).

Abstract: Provided herein are compositions, which include an active pharmaceutical ingredient and macrogol 15 hydroxystearate, and methods for using the same for treating diseases or disorder.

Abstract: In implementations of systems for generating and applying editing presets, a computing device implements a preset system to detect objects depicted in a digital image that is displayed in a user interface of an application for editing digital content. Input data is received describing an edited region of the digital image and properties of an editing operation performed in the edited region. The preset system identifies a particular detected object of the detected objects based on a bounding box of the particular detected object and an area of the edited region. An additional digital image is edited by applying the properties of the editing operation to a detected object that is depicted in the additional digital image based on a classification of the detected object and a classification of the particular detected object.

Abstract: The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: The disclosed implementations include a method performed by a data intake and query system. The method includes receiving a search query at a search head, the search query including a branching operation between sets of data, generating a first subquery and a second subquery corresponding to the sets of data for execution by a search node, generating instructions for an intermediary node to combine partial results of the first subquery and the second subquery and instructions to concurrently communicate the subqueries to a search node, and executing the query by providing the instructions for the intermediary node to the intermediary node and the subqueries to the search node, the intermediary node receiving sets of partial search results for the subqueries, performing at least a portion of the branching operation on the partial results, and communicating the combined results to another intermediary node or the search head.

Abstract: In one aspect, described herein is an intronic recognition element for splicing modifier (iREMS) that can be recognized by a compound provided herein. In another aspect, described herein are methods for modulating the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene contains an intronic REMS, and the methods utilizing a compound described herein. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene comprises an intronic REMS, and the methods utilizing a compound described herein. In another aspect, provided herein are artificial gene constructs comprising an intronic REMS, and uses of those artificial gene constructs to modulate protein production.

Abstract: Implementations claimed and described herein provide systems and methods for behavior assessment for an individual. In one implementation, user data for the individual is obtained from one or more digital sources. Categorized user data is created by transforming the user data into a platform independent format. The categorized user data is associated with a plurality of content-based bins. One or more behavioral insight categories are determined from the categorized user data. A plurality of behavioral metrics is determined based on the one or more behavioral insight categories and the categorized user data. A personality profile for the individual is generated by converting the plurality of behavioral metrics into one or more scores. A risk assessment for the individual is generated based on the personality profile.

Abstract: Implementations described and claimed herein provide systems and methods for risk assessment. In one implementation, a telematics-centric driving risk value is generated for a specific individual by determining one or more demographic segments corresponding to the specific individual and calculating one or more risk factor values associated with the one or more demographic segments using telematics data. A telematics-weighted personalized risk value is generated by: determining one or more telematics metrics from the telematics data; calculating a telematics persona risk value based on the one or more telematics metrics; calculating a behavioral persona risk value based on one or more behavioral metrics; calculating a household persona risk value based on one or more household metrics; and calculating a finance persona risk value based on one or more finance metrics.

Abstract: The disclosure is directed to a system for generating suggested routing for waste fluid from a source component to a sink component that can use the waste fluid in a fluid process according to some embodiments. In some embodiments, the system is configured to determine usability of the waste fluid in various fluid processes by accessing contamination history from a fluid processes and calculating an acceptable amount of contamination to use in a different fluid process. The system is configured to provide different types of waste fluid from different processes at various flowrates to one or more sink components to ensure contamination thresholds for the sink processes are not violated according to some embodiments.

Abstract: An application server may identify one or more contact identifiers associated with one or more contacts associated with a communication event. The application server may retrieve information associated with the one or more contacts from one or more data sources based on the one or more contact identifiers. The application server may generate, based on the information retrieved from the one or more data sources, a set of contact characteristics for the one or more contacts. The application server may identify one or more actions to be performed via the electronic communication application and associated with the communication event based at least in part on the generated set of contact characteristics and a response status. The application server may transmit, to a user device, an indication of the identified one or more actions.

Abstract: An allergy test kit including a housing, a biosensor supported by the housing, the biosensor operable to detect a presence of immunoglobin A (IgA) in a sample of sweat of a user and to generate IgA presence data, an allergen sensor supported by the housing, the allergen sensor operable to detect a presence of an allergen in a substance sample provided by the user and to generate allergen presence data, a processor operable to receive the IgA presence data from the biosensor and the allergen presence data from the allergen sensor, and a memory operable to store the IgA presence data and the allergen presence data.