Abstract: This invention relates to methods and compositions for treatment of inv (16) leukemia and particularly to treatment of acute myeloid leukemia. Disclosed is a method of treating inv (16) leukemia comprising the step of administering to a subject in in need thereof a therapeutically effective combination of a) a compound of the formula (1) (1) and b) a BRD4 inhibitor selected from the group consisting of JQ1, CeMMECZ, 1-BET 151 (or GSK1210151A), 1-BET 762 (or GSK525762), PFI-1, bromosporine, OTX-015 (or MK-8628), TEN-010, CPI-203, CPI-0610, RVX-208, BI2536, TG101348, LY294002, ABBV-075 (or mivebresib), FT-1101, ZEN003694, pharmaceutically acceptable salts and mixtures thereof. The therapeutically effective combination synergistically inhibits proliferation of inv (16) leukemia cells. This invention also relates to pharmaceutical compositions comprising a therapeutically effective combination of the compound of formula (1) and the BRD4 inhibitor and a pharmaceutically acceptable excipient.

Abstract: The present disclosure describes systems, non-transitory computer-readable media, and methods for generating object-specific-preset edits to be later applied to other digital images depicting a same object type or applying a previously generated object-specific-preset edit to an object of the same object type within a target digital image. For example, in some cases, the disclosed systems generate an object-specific-preset edit by determining a region of a particular localized edit in an edited digital image, identifying an edited object corresponding to the localized edit, and storing in a digital-image-editing document an object tag for the edited object and instructions for the localized edit. In certain implementations, the disclosed systems further apply such an object-specific-preset edit to a target object in a target digital image by determining transformed-positioning parameters for a localized edit from the object-specific-preset edit to the target object.

Abstract: Various methods and systems are provided for generating and displaying summaries of patient information extracted from one or more medical reports stored in an electronic medical record (EMR) of a patient. In one example, a method includes receiving text data of a patient; entering the text data as input into a plurality of entity recognition models, each entity recognition model of the plurality of entity recognition models trained to label instances of a respective entity in the text data; aggregating the labeled text data outputted by each entity recognition model; generating a summary of the text data based on the aggregated labeled text data; and displaying and/or saving the summary and/or the aggregated labeled text data.

Abstract: In implementations of systems for generating and propagating personal masking edits, a computing device implements a mask system to detect a face of a person depicted in a digital image displayed in a user interface of an application for editing digital content. The mask system determines an identifier for the person based on an identifier for the face. Edit data is received describing properties of an editing operation and a type of mask used to modify a particular portion of the person depicted in the digital image. The mask system edits an additional digital image identified based on the identifier of the person using the type of mask and the properties of the editing operation to modify the particular portion of the person as depicted in the additional digital image.

Abstract: The disclosure provides for resorcinol-based compounds, pharmaceutical compositions made therefrom, and methods of treatment thereof for various disorders, including neoplastic disorders.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof.

Abstract: According to examples, an apparatus includes a processor that is to cause an application to be provided through which information pertaining to a first user is to be displayed, receive authentication information of a second user, in which the authentication information includes an identifier of the second user and information that the second user uses for authentication to access a web-based application, determine whether the identifier of the second user is linked to an identifier of the first user, determine whether the authentication information authenticates the second user to access the web-based application, and based on a determination that the identifier of the second user is linked to the identifier of the first user and the authentication information authenticates the second user to access the web-based application, perm it the second user to access the information pertaining to the first user through the application.

Abstract: Embodiments of the invention are directed to a computer-implemented method. A non-limiting example of the computer-implemented method includes accessing, using a processor system, a process-step sequence that includes a plurality process-steps and a plurality of queue-times. A process-step sequence mining operation is applied to the process-step sequence, wherein the process-step sequence mining operation is operable to make a prediction of an impact of a portion of the process-step sequence on a characteristic of a product generated by the process-step sequence.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

Abstract: A system and method are provided herein for modeling of force vectors for serial casts to correct orthopedic deformities includes a camera configured to capture a three-dimensional image of the deformity, a computing device programmed to generate a three-dimensional model of the deformity based on the image of the deformity, determine the boundary conditions for the deformity based on the three-dimensional image of the deformity, and generate force vectors for a series of casts to correct the deformity. In exemplary embodiments, the system can print a series of casts to correct the deformity.

Abstract: The present disclosure provides compounds of Formula (I), their methods of preparation, their methods of regeneration of the compound of Formula (I), and their methods of use for binding perfluoroalkyl substances (PFAS) contaminates from sources of PFAS contaminated water.

Abstract: Embodiments are disclosed for determining scene-based editing recommendations for video content. A method of determining scene-based editing recommendations for video content includes receiving an input video comprising video content, dividing the input video into the plurality of scenes based on the video content, identifying a representative frame for each scene, determining a plurality of editing settings for each representative frame, determining editing settings for each scene based on an effectiveness score, and generating an output video using the input video and the editing settings for each scene.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: A mounting device has a locking housing with a locking arm that pivots between an open, unlocked position, and a closed, locked position. The locking arm extending to a latch end having a latch hole. A bottom end of the dispensing container is placed within a container receiving space of the locking housing, and the locking arm is moved to the closed, locked position to engage the annular groove of the dispensing container to lock the dispensing container within the locking housing. The device further includes a magnetic locking mechanism for locking the locking arm in the closed, locked position.

Abstract: The present disclosure describes systems, non-transitory computer-readable media, and methods for generating object-specific-preset edits to be later applied to other digital images depicting a same object type or applying a previously generated object-specific-preset edit to an object of the same object type within a target digital image. For example, in some cases, the disclosed systems generate an object-specific-preset edit by determining a region of a particular localized edit in an edited digital image, identifying an edited object corresponding to the localized edit, and storing in a digital-image-editing document an object tag for the edited object and instructions for the localized edit. In certain implementations, the disclosed systems further apply such an object-specific-preset edit to a target object in a target digital image by determining transformed-positioning parameters for a localized edit from the object-specific-preset edit to the target object.

Abstract: A method of treating and/or preventing Rift Valley fever, comprising administering an effective amount of a compound of formula (I), formula (II), formula (III), formula (IV), formula (V), formula (VI), formula (VII) or formula (VIII), or a salt thereof, to a subject need thereof; a pharmaceutical composition comprising a compound of formula (I), formula (II), formula (III), formula (IV), formula (V), formula (VI), formula (VII) or formula (VIII), or a salt thereof, and a pharmaceutically acceptable carrier; and a pharmaceutical composition comprising a compound selected from the group consisting of compound WMA-RV1, compound WMA-RV2, compound MA-RV3, compound WMA-RV4, compound WMA-RV5, compound WMA-RV6, compound WMA-RV7, or compound WMA-RV8, or a salt thereof, and a pharmaceutically acceptable carrier.

Abstract: A method of managing user experience with a virtual reality (VR) headset includes: with a server, receiving data from a number of sensors that are detecting parameters associated with a user during use of the VR headset; with the server, analyzing the data from the sensors to predict a negative effect on the user from the use of the VR headset; and with the server, taking action to minimize the negative effect on the user that is predicted.

Abstract: An artificial intelligence (AI) based method to enhance launching of an application at a user equipment (UE) is provided. The method includes monitoring launch of the application on the UE. The method includes determining an event to be executed upon the launch of the application. The method includes categorizing the event into one of a UI updating event and a non-UI updating event. Further, generating an execution flow based on the categorization, wherein the execution flow is indicative of prioritizing the UI updating event for execution before the non-UI updating event such that prioritization prevents a mismatch of the UI components during the launch. The method includes storing the execution flow and executing the stored execution flow during a subsequent launch of the application, such that launching of the at application is enhanced.

Abstract: A control circuit obtains a first set of rules that define a conveyability range for containers as a function of conveyability constraints pertaining to an intermediary distribution facility. The control circuit also accesses conveyability constraint information for the intermediary distribution facility and generates a conveyability range for that facility by evaluating the constraint information against the first set of rules. The control circuit obtains a second set of rules that define an objective function that uses the conveyability range as a constraint to determine an optimal container pack size for the given item. (By one approach these teachings will also accommodate using at least two additional constraints, such as a so-called days-of-supply (DOS) constraint and a so-called pack-and-a-half constraint.) The control circuit then generates an optimal container pack size for the given item by evaluating the objective function against the conveyability range (and other selected constraints).