Abstract: A method includes receiving, via at least one processor, data from a plurality of data sources disposed within an area, the data including area data, emergency event data, and emergency resource data; generating, via the at least one processor, based on the data, a visualization including a graphical representation of the area based on the area data, the emergency event data, the emergency resource data, or any combination thereof; determining, based on an interaction with the visualization, an emergency response plan for a vehicle, wherein the response plan includes an evacuation plan; sending the emergency response plan to a vehicle system associated with the vehicle, wherein the vehicle system is configured to: determine a location associated with the emergency response plan; determine a route to the location; and send instructions to one or more traffic assets along the route to the location, the instructions configured to cause the one or more traffic assets to adjust one or more signals.

Abstract: An example of the modular outpost pipeline can make complex branching decisions at stages along the pipeline based on attributes of the data already gathered. This allows modifications to scans in progress within the outpost-based pipeline, and near-real-time sharing of specific scan data to external tools. The logic necessary can be implemented in any outpost pipeline stage but is preferentially accomplished by using secondary orchestrator stages inserted after the pipeline stages where relevant data has been acquired.

Abstract: A luminaire with a tool-less assembly feature that enhances ease of installation and serviceability in the field. The luminaire's housing defines a compartment accessible via a window adjacent a pair of opposed shoulders. The luminaire further includes a lighting module dimensioned to be received and retained in the window in an interference fit with the shoulders. The lighting module may include an LED module/light guide plate and/or an LED refractor assembly/LED gear tray. A resilient member is supported on the housing in position to abut the lighting module and deflect during insertion of the lighting module through the window, and to at least partially resile to maintain the lighting module against the shoulders in an operative position on the housing. Further, the resilient member is positioned to deflect during removal and to resile to tilt or otherwise assist in ejecting the lighting module from the housing during tool-less disassembly.

Abstract: An under-mat to be positioned under an exercise mat, to make the exercise mat a smart mat. The under-mat including a plurality of sensors to monitor a user's health data, while the user is performing exercises, and to provide data to the user.

Abstract: Various embodiments relate generally to data science and data analysis, computer software and systems, and wired and wireless network communications to provide an interface between repositories of disparate datasets and computing machine-based entities that seek access to the datasets, and, more specifically, to a computing and data storage platform that facilitates consolidation of one or more datasets, whereby a collaborative data layer and associated logic facilitate, for example, efficient access to, and implementation of, collaborative datasets. In some examples, a system may include an atomized workflow loader configured to receive an atomized dataset to load into a data store, and to determine resource requirements data to describe at least one resource requirement. The atomized workflow loader may be further configured to select a data store type based on a resource requirement, and perform a load operation of the atomized dataset as a function of the data store type.

Abstract: The invention provides immunoconjugates of Formula I comprising an anti-CEA antibody linked by conjugation to one or more 8-phenyl-2-aminobenzazepine derivatives. The invention also provides 8-phenyl-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

Abstract: A luminaire with a tool-less assembly feature that enhances ease of installation and serviceability in the field. The luminaire's housing defines a compartment accessible via a window adjacent a pair of opposed shoulders. The luminaire further includes a lighting module dimensioned to be received and retained in the window in an interference fit with the shoulders. The lighting module may include an LED module/light guide plate and/or an LED refractor assembly/LED gear tray. A resilient member is supported on the housing in position to abut the lighting module and deflect during insertion of the lighting module through the window, and to at least partially resile to maintain the lighting module against the shoulders in an operative position on the housing. Further, the resilient member is positioned to deflect during removal and to resile to tilt or otherwise assist in ejecting the lighting module from the housing during tool-less disassembly.

Abstract: The invention provides immunoconjugates of Formula I comprising an anti-HER2 antibody linked by conjugation to one or more 8-Het-2-aminobenzazepine derivatives. The invention also provides 8-Het-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

Abstract: The invention provides immunoconjugates of Formula I comprising an anti-HER2 antibody linked by conjugation to one or more 8-phenyl-2-aminobenzazepine derivatives. The invention also provides 8-phenyl-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

Abstract: The invention provides immunoconjugates of Formula I comprising an anti-PD-L1 antibody linked by conjugation to one or more 8-Cyc-2-aminobenzazepine derivatives. The invention also provides 8-Cyc-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. In an embodiment, a pharmaceutical composition can be in a liquid dosage form and can comprise a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof as an adjuvant and a therapeutic agent. In another embodiment, a method of adjuvant treating a disorder or condition can comprising administering the pharmaceutical composition to a patient.

Abstract: Trisubstituted triazine antioxidants.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

Abstract: The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a linker, wherein each adjuvant moiety is covalently bonded to the antibody via the linker. Methods for treating cancer with the immunoconjugates of the invention are also described.

Abstract: The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a linker, wherein each adjuvant moiety is covalently bonded to the antibody via the linker. Methods for treating cancer with the immunoconjugates of the invention are also described.

Abstract: The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

Abstract: The invention provides an immunoconjugate of formula: or pharmaceutically acceptable salt thereof, wherein subscript r is an integer from 1 to 10, subscript n is an integer from about 2 to about 25, and “Ab” is an antibody construct that has an antigen binding domain that binds HER2. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.

Abstract: The invention provides a method for producing an immunoconjugate, the method comprising combining one or more compounds of Formula I and an antibody construct of Formula II to provide the immunoconjugate of Formula III, wherein TA is a therapeutic agent, L is a linker, r is an integer from 1 to 50, Ar is an aromatic moiety comprising a substituent selected from PEG, —SO2CX3, —NR3+, —NO2, —SO3R, —SO2R, —CN, —CX3, —PO3R2, —OPO3R2, and salts thereof, each R independently is H, CX3, or C1-C4 alkyl, each X independently is hydrogen or a halogen, Y is CH2, PEG, or a bond, n is an integer from 1 to 4, and PEG has the formula: —(CH2CH2O)m-(CH2)p—, where p is an integer from 1 to 5 and m is an integer from 2 to 50. The invention also provides an immunoconjugate and a composition of immunoconjugates formed from said method.

Abstract: A method of allowing a player to play a gaming machine is described herein. The method includes displaying, on a display device, a game including at least one reel. The at least one reel includes a plurality of symbol positions that have a plurality of normal symbols positions and a plurality of special symbol positions. The outcome of a game is randomly generated and displayed on the display device. The method also includes randomly determining a number of special symbol positions being displayed with the at least one reel and spinning and stopping the at least one reel to display the generated game outcome, wherein the at least one reel includes the plurality of symbol positions having the determined number of special symbol positions.