Abstract: A method of allowing a player to play a gaming machine is described herein. The method includes displaying, on a display device, a game including at least one reel. The at least one reel includes a plurality of symbol positions that have a plurality of normal symbols positions and a plurality of special symbol positions. The outcome of a game is randomly generated and displayed on the display device. The method also includes randomly determining a number of special symbol positions being displayed with the at least one reel and spinning and stopping the at least one reel to display the generated game outcome, wherein the at least one reel includes the plurality of symbol positions having the determined number of special symbol positions.

Abstract: The application provides macromolecule-supported compounds of Formula I or III comprising a macromolecular support linked by conjugation to one or more aminobenzazepine derivatives. The application also provides aminobenzazepine derivative intermediate compositions of Formula II comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the macromolecule-supported compounds through a linker or linking moiety. The application further provides compositions comprising the macromolecule-supported compounds, as well as methods of treating cancer with the macromolecule-supported compounds.

Abstract: A lung exercise apparatus and method with an enclosure, with an inside, an outside and an open top, configured to hold a liquid of a first density. An additive to the liquid that increases the first density such that a person in the liquid is more buoyant. Weight removably connectable with the person such that a person in the enclosure is held vertical in the enclosure and partially immersed in the liquid below a surface of the liquid and with some of a person's body above the surface of the liquid. And a harness that is removably connectable with the person to hold some of the person's body above the surface of the liquid where lungs in a person's body are below the surface of the liquid.

Abstract: A luminaire with a tool-less assembly feature that enhances ease of installation and serviceability in the field. The luminaire's housing defines a compartment accessible via a window adjacent a pair of opposed shoulders. The luminaire further includes a lighting module dimensioned to be received and retained in the window in an interference fit with the shoulders. The lighting module may include an LED module/light guide plate and/or an LED refractor assembly/LED gear tray. A resilient member is supported on the housing in position to abut the lighting module and deflect during insertion of the lighting module through the window, and to at least partially resile to maintain the lighting module against the shoulders in an operative position on the housing. Further, the resilient member is positioned to deflect during removal and to resile to tilt or otherwise assist in ejecting the lighting module from the housing during tool-less disassembly.

Abstract: The invention provides an immunoconjugate of formula: or pharmaceutically acceptable salt thereof, wherein subscript r is an integer from 1 to 10, subscript n is an integer from about 2 to about 25, and “Ab” is an antibody construct that has an antigen binding domain that binds HER2. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.

Abstract: The invention provides an immunoconjugate of formula (I) or (II). Antibody-adjuvant immunoconjugates of the invention, comprising an antibody construct that has an antigen binding domain that binds human epidermal growth factor receptor 2 (“HER2”) linked to one or more adjuvants, demonstrate superior pharmacological properties over conventional antibody conjugates. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.

Abstract: The invention provides an immunoconjugate of formula (I) or (II). Antibody-adjuvant immunoconjugates of the invention, comprising an antibody construct that has an antigen binding domain that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants, demonstrate superior pharmacological properties over conventional antibody conjugates. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.

Abstract: A luminaire with a tool-less assembly feature that enhances ease of installation and serviceability in the field. The luminaire's housing defines a compartment accessible via a window adjacent a pair of opposed shoulders. The luminaire further includes a lighting module dimensioned to be received and retained in the window in an interference fit with the shoulders. The lighting module may include an LED module/light guide plate and/or an LED refractor assembly/LED gear tray. A resilient member is supported on the housing in position to abut the lighting module and deflect during insertion of the lighting module through the window, and to at least partially resile to maintain the lighting module against the shoulders in an operative position on the housing. Further, the resilient member is positioned to deflect during removal and to resile to tilt or otherwise assist in ejecting the lighting module from the housing during tool-less disassembly.

Abstract: The invention provides immunoconjugates of Formula I comprising an anti-CEA antibody linked by conjugation to one or more 8-Het-2-aminobenzazepine derivatives. The invention also provides 8-Het-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

Abstract: The invention provides an immunoconjugate of formula (I) or (II) Antibody-adjuvant immunoconjugates of the invention, comprising an antibody construct that has an antigen binding domain that binds carcinoembryonic antigen (“CEA”) linked to one or more adjuvants, demonstrate superior pharmacological properties over conventional antibody conjugates. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.

Abstract: The invention provides a macromolecule-supported compound of formula (I) or (II). Macromolecule-supported compounds of the invention, comprising macromolecular support linked to one or more TLR agonists, are recognized by TLRs (e.g., TLR7 and/or TLR8) with high affinity providing utility in therapeutics, diagnostics, and chemical assays. The invention further provides compositions comprising and methods of treating cancer with the macromolecule-supported compounds.

Abstract: Trisubstituted triazines having the formula: wherein: X is O and n is 0 or 1, Y is OH, NH2 or CH2NH2, Q is P, P?O, CH or N, when Q is P, R is phenyl, when Q is P?O, Z is R or OR, and R is alkyl or phenyl, when Q is CH, Z is PO(R)2 or PO(OR)2, when Q is N, Z is R, and their uses as epoxy and cyclic carbonate polymer curing agents.

Abstract: The invention provides an immunoconjugate of formula: or pharmaceutically acceptable salt thereof, wherein subscript r is an integer from 1 to 10, subscript n is an integer from about 2 to about 25, and “Ab” is an antibody construct that has an antigen binding domain that binds HER2. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.

Abstract: A luminaire with a tool-less assembly feature that enhances ease of installation and serviceability in the field. The luminaire's housing defines a compartment accessible via a window adjacent a pair of opposed shoulders. The luminaire further includes a lighting module dimensioned to be received and retained in the window in an interference fit with the shoulders. The lighting module may include an LED module/light guide plate and/or an LED refractor assembly/LED gear tray. A resilient member is supported on the housing in position to abut the lighting module and deflect during insertion of the lighting module through the window, and to at least partially resile to maintain the lighting module against the shoulders in an operative position on the housing. Further, the resilient member is positioned to deflect during removal and to resile to tilt or otherwise assist in ejecting the lighting module from the housing during tool-less disassembly.

Abstract: Trisubstituted triazine antioxidants.

Abstract: The present disclosure disclosed a display information processing device and method suitable for a host system, the method comprises: determining whether specification of interfaces of a plurality of extended display devices connected to extension interfaces conforms to the default specification of interfaces of the host system; calling drivers corresponding to a plurality of extended display devices from the host system to drive the plurality of extended display devices with the specification of interfaces conforming to the default specification of interfaces of the host system; obtaining resolution information from the plurality of extended display devices, respectively; determining a common resolution from the resolution information of the plurality of extended display devices; and outputting display information of a main display device to the plurality of extended display devices based on the common resolution.

Abstract: A method for producing an immunoconjugate, the method comprising combining one or more compounds of Formula I and an antibody of Formula II, wherein Formula II is an antibody with one or more lysine residues, in an aqueous solution buffered at a pH of about 7.5 to about 9 until at least 33 mol % of the one or more compounds of Formula I is conjugated to the antibody of Formula II to provide the immunoconjugate of Formula III, wherein Adj is an adjuvant, Z is —CH2—, —C(O)NH—, —C(O)O—, or —C(O)—, L is a linker, E is an ester, and r is the average number of adjuvants attached to the antibody and is a positive number up to about 8, in a first buffered aqueous solution.

Abstract: The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a linker, wherein each adjuvant moiety is covalently bonded to the antibody via the linker. Methods for treating cancer with the immunoconjugates of the invention are also described.

Abstract: The invention provides an immunoconjugate of formula: (I), or pharmaceutically acceptable salt thereof, wherein subscript r is an integer from 1 to 10, subscript n is an integer from about 2 to about 50, “Adj” is an adjuvant moiety, and “Ab” is an antibody construct that has an antigen binding domain that binds EGFR. The invention also provides compositions comprising the immunoconjugate. The invention further provides methods of treating cancer with the immunoconjugate.

Abstract: Trisubstituted triazine antioxidants.