Abstract: An optically variable device and method of manufacturing the device is disclosed, the device including a plurality of zero-order diffraction grating elements some of which are modulated such that a coloured at least partially polarized image is visible to a person viewing the device, observing a first optically variable effect when the device is rotated about an axis substantially perpendicular to the plane, and a second optically variable effect when the device is viewed under polarized light and rotated about an axis substantially perpendicular to or parallel with the plane. The device is particularly suitable for security documents such as bank notes. Preferably, the first optically variable effect is produced by a change in brightness and/or color of the grating elements and the second optically variable effect may likewise be produced by a change in brightness and/or color of the grating elements.

Abstract: The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a linker, wherein each adjuvant moiety is covalently bonded to the antibody via the linker which comprises an ethylene glycol group or glycine residue. Methods for treating cancer with the immunoconjugates of the invention are also described.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A bucket handle retainer with a substantially flat rectilinear resilient plate. The plate has an upper tip that corresponds to the inside dimension of the internal cavity of the handle holding portion of a standard five gallon bucket. The plate includes a spring biased finger capable of frictionally engaging the inside wall of the handle holding portion. The plate also includes a holding portion capable of being grasped by a user's fingers to insert or remove the plate from the handle holding portion of the bucket. A preferred embodiment includes the handle retainer is injection molded from nylon plastic.

Abstract: A bucket handle retainer with a substantially flat rectilinear resilient plate. The plate has an upper tip that corresponds to the inside dimension of the internal cavity of the handle holding portion of a standard five gallon bucket. The plate includes a spring biased finger capable of frictionally engaging the inside wall of the handle holding portion. The plate also includes a holding portion capable of being grasped by a user's fingers to insert or remove the plate from the handle holding portion of the bucket. A preferred embodiment includes the handle retainer is injection molded from nylon plastic.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: An optical device, preferably for use in security devices and documents, comprising an arrangement of wavelength dependant optical phase, and optionally amplitude, modifying optical elements on a first surface of a substrate, each of the optical elements being in the form of an optical antenna and configured to produce a local phase change to reflected and/or transmitted electromagnetic waves, the arrangement configured such that the combined action of each of the optical elements produces a pre-defined optical effect on reflection and/or transmission observable by a viewer when the arrangement is illuminated by an external electromagnetic source.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds of Formula (Ia) are disclosed which are inhibitors of Interleukin-1 receptor associated kinase (IRAK4). Methods of treatment, methods of synthesis, and intermediates are also disclosed as defined in the specification.

Abstract: A hybrid security device for security documents and the like, with the microstructure for a first optically variable device (OVD) and the microstructure for a second OVD mutually interlace or interspersed. The first microstructure has a height profile that differs from that of the second microstructure by more than 0.5 microns. Suitable fabrication processes for the hybrid security device are also disclosed.

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

Abstract: An optical device comprising an at least substantially transparent substrate having a first side comprising a source layer having an arrangement of source elements and a second side comprising an Optically Variable Device (OVD) layer having a corresponding arrangement of diffractive elements, wherein each source element is configured to, upon illumination of the first side, provide an embedded light source for an associated diffraction element, and wherein the diffractive elements are configured for producing an optical effect observable when the diffractive elements are viewed by a viewer, such as the naked eye, upon illumination by the source elements.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A bucket handle retainer with a substantially flat rectilinear resilient plate. The plate has an upper tip that corresponds to the inside dimension of the internal cavity of the handle holding portion of a standard five gallon bucket. The plate includes a spring biased finger capable of frictionally engaging the inside wall of the handle holding portion. The plate also includes a holding portion capable of being grasped by a user's fingers to insert or remove the plate from the handle holding portion of the bucket. A preferred embodiment includes the handle retainer is injection molded from nylon plastic.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A system for providing an award to a player is described herein. The system includes a plurality of gaming devices and a controller coupled to each of the gaming devices. Each gaming device is configured to receive a wager from a player and responsively display a game. The controller is configured to receive a signal indicative of a wager being received by at least one of the gaming devices, determine a range of award numbers as a function of at least one previous wager, randomly select an award number from the range of award numbers, and responsively provide an award to the player being associated with the at least one gaming device as a function of the randomly selected award number.

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

Abstract: The present invention provides small molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

Abstract: An aquaponic system, having at least one farming section; each farming section has an aquaculture unit, a vegetable farming unit and a water circulation unit; the aquaculture unit has an outer tank and an aquaculture tank inside the outer tank; the vegetable farming unit has a vegetable farming column and a water collection tank at a bottom part thereof; the water circulation unit has a filter tank, a water pump, and at least one guiding pipe extending from the aquaculture tank to the vegetable farming column; a water inlet of the filter tank is connected with a water outlet of the aquaculture tank; a water outlet of the filter tank is connected with a water inlet of the aquaculture tank; one end of the water pump is connected with the water collection tank, another end of the water pump is connected with the aquaculture tank.

Abstract: A method of allowing a player to play a gaming machine is described herein. The method includes displaying a game including a plurality of reels displayed in a display area. Each reel of includes a reel strip including a plurality of normal symbols positions and a plurality of special symbol positions. The method includes randomly generating an outcome of the game and displays the game outcome on the display device, wherein the game outcome including at least one special symbol position being displayed on at least one reel of the plurality of reels in the display area. The method also includes determining a symbol selection factor as a function of the generated game outcome, randomly selecting at least one special symbol as a function of the symbol selection factor, and displaying the game outcome including the selected special symbol displayed in the special symbol position.

Abstract: The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.