Abstract: The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

Abstract: A method for joining a communication group by receiving and processing light and/or sound signals in a mobile device. The signaling may be light or audible signals, such as lights and/or music, that may be emitted in particular sequences. The mobile device may receive the light and/or sound signals with sensors, such as cameras and/or microphones, and may process the light and/or sound signals to obtain information encoded within the signals. The mobile device may decode detected signaling information and identify connectivity data that may be used to join and transmit messages to the communication group. In an embodiment, light and/or sound signals related to unknown third parties may be used by the mobile device to identify the third party based on queries to the communication group. In an embodiment, the mobile device may determine parameters for receiving and/or transmitting signals based on ambient conditions, such as ambient noise.

Abstract: A gaming device is described herein. The gaming device includes a display unit and a controller that is coupled to the display unit. The display unit is configured to display a game including a plurality of reels being displayed in a display grid. Each reel is adapted to display one of a plurality of symbols. The controller is configured to randomly determine an outcome of the game, select a reel configuration including a plurality of reel groups, determine, for each reel group, a single random symbol being displayed in each reel of the corresponding reel group in the determined outcome, spin and stop each reel of the corresponding reel groups to display the outcome including displaying the same symbols in each reel of the corresponding reel group during rotation, and provide an award to the player as a function of the determined outcome.

Abstract: A hybrid security device for security documents and the like, with the microstructure for a first optically variable device (OVD) and the microstructure for a second OVD mutually interlace or interspersed. The first microstructure has a height profile that differs from that of the second microstructure by more than 0.5 microns. Suitable fabrication processes for the hybrid security device are also disclosed.

Abstract: A system for providing an award to a player is described herein. The system includes a plurality of gaming devices and a controller coupled to each of the gaming devices. Each gaming device is configured to receive a wager from a player and responsively display a game. The controller is configured to receive a signal indicative of a wager being received by at least one of the gaming devices, determine a range of award numbers as a function of at least one previous wager, randomly select an award number from the range of award numbers, and responsively provide an award to the player being associated with the at least one gaming device as a function of the randomly selected award number.

Abstract: A game outcome generator for a gaming machine is configured with first and second outcome generators. One of the two outcome generators is selected to generate a game outcome for each game. The first outcome generator selects a game result and then selects or generates game data which corresponds to the selected result, such as by selecting a result and associated game data from one or more templates of results and associated game data. The second outcome generator selects game data and then determines the result which corresponds to the selected game data. The game data may comprise slot symbols or reel stops and the results may comprise losing outcomes having no award or winning outcomes having awards of one or more credits.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: Games and gaming machines are provided with an outcome normalization feature. In a method of presenting and playing a game, a game outcome is selected. If the outcome has been selected a minimum number of times since the last time the outcome was presented, that game outcome is used as the outcome of the game and is presented to the player. Otherwise, another game outcome is selected and the process is repeated. A counter or tally may be utilized to tracking the number of times a particular outcome has been selected, wherein the counter is incremented when the outcome is selected and is reset to a base value when the outcome is presented.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: An aquaponic system, having at least one farming section; each farming section has an aquaculture unit, a vegetable farming unit and a water circulation unit; the aquaculture unit has an outer tank and an aquaculture tank inside the outer tank; the vegetable farming unit has a vegetable farming column and a water collection tank at a bottom part thereof; the water circulation unit has a filter tank, a water pump, and at least one guiding pipe extending from the aquaculture tank to the vegetable farming column; a water inlet of the filter tank is connected with a water outlet of the aquaculture tank; a water outlet of the filter tank is connected with a water inlet of the aquaculture tank; one end of the water pump is connected with the water collection tank, another end of the water pump is connected with the aquaculture tank.

Abstract: A waste container for disposing sanitary waste, such as soiled diapers, comprises a canister having a storage space, an opening at an upper end and a bottom at a lower end. A retainer frame is pivotally attached to the canister and has an aperture for inserting a trash bag through the aperture and folding an upper edge of the trash bag over the retainer frame. A retainer is pivotally attached to the canister and has a rim that inserts into the aperture of the retainer frame to retain the trash bag. A lid having a hole which aligns with the aperture of the retainer frame is pivotally attached to the canister for allowing the lid to pivot between a closed position covering the opening and an open position. A slid door is coupled to the lid and is slidable between a closed position and an open position.

Abstract: A game outcome generator for a gaming machine is configured with first and second outcome generators. One of the two outcome generators is selected to generate a game outcome for each game. The first outcome generator selects a game result and then selects or generates game data which corresponds to the selected result, such as by selecting a result and associated game data from one or more templates of results and associated game data. The second outcome generator selects game data and then determines the result which corresponds to the selected game data. The game data may comprise slot symbols or reel stops and the results may comprise losing outcomes having no award or winning outcomes having awards of one or more credits.

Abstract: A gaming machine and method are provided which allow a player to play a gaming machine. The gaming machine and method allow a player to make a wager on a first primary game and randomly generate an outcome of the first primary game. The gaming machine determines if an anticipation event triggering condition has occurred based at least in part on an anticipation event probability associated with the first primary game, displays an anticipation event on the display device if the anticipation event triggering condition has occurred, and displays the first primary game outcome on the display device. A number of anticipation events that have occurred during the first gaming session is calculated, and the anticipation event probability is modifying based at least in part on the number of anticipation events that have occurred. The player is awarded an award if the first primary game outcome is a winning outcome.

Abstract: A gaming device is described herein. The gaming device includes a display unit and a controller that is coupled to the display unit. The display unit is configured to display a game including a plurality of reels being displayed in a display grid. Each reel is adapted to display one of a plurality of symbols. The controller is configured to randomly determine an outcome of the game, select a reel configuration including a plurality of reel groups, determine, for each reel group, a single random symbol being displayed in each reel of the corresponding reel group in the determined outcome, spin and stop each reel of the corresponding reel groups to display the outcome including displaying the same symbols in each reel of the corresponding reel group during rotation, and provide an award to the player as a function of the determined outcome.

Abstract: A method of allowing a player to play a gaming machine is described herein. The method includes displaying, on a display device, a game including at least one reel being displayed with a plurality of normal symbol positions and a plurality of special symbol positions. The method includes determining a first amount of special symbol positions being displayed in a first instance of the game, spinning and stopping the at least one reel to display the first instance on the display device including the at least one reel being displayed with the first amount of special symbol positions, determining a second amount of special symbol positions being displayed in a second instance of the game, and spinning and stopping the at least one reel to display the second instance including the at least one reel being displayed with the second amount of special symbol positions.

Abstract: Methods, devices and systems enable efficient organizations of group communications on a mobile device. The mobile device may be configured to receive location information from other mobile devices in a communication system, determine the current location and orientation of the mobile device, determine directions and distances from the mobile device to each of the other mobile devices, and generate a first-person perspective and/or top-down perspective display showing relative locations of the other mobile devices. Other multiple mobile devices may be represented in the display as images (e.g., icons, avatars, directional indicators, etc.). The display may provide a user interface to enable a user to quickly organize other mobile devices into groups and initiate group communications with some of the other mobile devices. The mobile device may be configured to group the displayed images into one or more communication units and establish communication links with mobile devices in the communication units.

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

Abstract: A slot game is provided. A display device displays a plurality of reels. During the slot game the reels are spun and an outcome of the game is randomly determined. The outcome of the game is displayed on the display device in a grid comprised of a plurality of symbol positions in a predetermined arrangement. One of the symbols from a corresponding reel are displayed at each symbol position. The spinning reels are visible in the grid during play of the game. The controller awards the player an award as a function of the wager, the outcome of the game and a predetermined paytable. A first one of the reels contains a stack of adjacent, similar symbols. The stack of adjacent similar symbols are displayed with a first single graphic overlay.

Abstract: A system for providing an award to a player is described herein. The system includes a plurality of gaming devices and a controller coupled to each of the gaming devices. Each gaming device is configured to receive a wager from a player and responsively display a game. The controller is configured to receive a signal indicative of a wager being received by at least one of the gaming devices, determine a range of award numbers as a function of at least one previous wager, randomly select an award number from the range of award numbers, and responsively provide an award to the player being associated with the at least one gaming device as a function of the randomly selected award number.