Patents by Inventor Arthur M. Krieg

Arthur M. Krieg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110033421
    Abstract: Methods and compositions are provided for extending the clinical utility of IFN-? in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-? treatment and reduce IFN-? treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
    Type: Application
    Filed: July 13, 2010
    Publication date: February 10, 2011
    Applicants: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc., University of Iowa Research Foundation
    Inventors: Gunther Hartmann, Robert L. Bratzler, Arthur M. Krieg
  • Patent number: 7879810
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: February 1, 2011
    Assignees: University of Iowa Research Foundation, The United States of America, as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 7807803
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: October 5, 2010
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Patent number: 7795235
    Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: September 14, 2010
    Assignees: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann
  • Patent number: 7776344
    Abstract: Methods and compositions are provided for extending the clinical utility of IFN-? in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-? treatment and reduce IFN-? treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: August 17, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.
    Inventors: Gunther Hartmann, Robert L. Bratzler, Arthur M. Krieg
  • Publication number: 20100183639
    Abstract: The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic acid.
    Type: Application
    Filed: November 10, 2009
    Publication date: July 22, 2010
    Applicants: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Eugen Uhlmann, Jörg Vollmer, Arthur M. Krieg
  • Patent number: 7723022
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: May 25, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 7723500
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: May 25, 2010
    Assignees: University of Iowa Research Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20100125101
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: March 25, 2009
    Publication date: May 20, 2010
    Inventors: Arthur M. Krieg, Joel N. Kline
  • Patent number: 7713529
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: May 11, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 7674777
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: March 9, 2010
    Assignees: University of Iowa Research Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Publication number: 20090311277
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Application
    Filed: May 26, 2009
    Publication date: December 17, 2009
    Applicant: COLEY PHARMACEUTICAL GROUP, INC.
    Inventor: ARTHUR M. KRIEG
  • Patent number: 7615539
    Abstract: The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic acid.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: November 10, 2009
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Eugen Uhlmann, Jörg Vollmer, Arthur M. Krieg
  • Patent number: 7605138
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: October 20, 2009
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Patent number: 7576066
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: August 18, 2009
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Publication number: 20090202575
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Application
    Filed: October 9, 2008
    Publication date: August 13, 2009
    Applicants: University of Iowa Research Foundation, The US, as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Joel N. Kline, Dennis Klinman
  • Patent number: 7569553
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: August 4, 2009
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Publication number: 20090191188
    Abstract: The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.
    Type: Application
    Filed: February 26, 2009
    Publication date: July 30, 2009
    Applicants: University of Iowa Research Foundation, Coley Pharmaceutical GmbH
    Inventors: Arthur M. Krieg, Christian Schetter, Jorg Vollmer
  • Patent number: 7566703
    Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: July 28, 2009
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann
  • Publication number: 20090142362
    Abstract: Improved vaccine compositions and methods of use thereof are described that elicit production of antibodies in an individual to the individual's own endogenous cholesteryl ester transfer protein (CETP).
    Type: Application
    Filed: November 6, 2007
    Publication date: June 4, 2009
    Applicants: Avant Immunotherapeutics, Inc., Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Lawrence J. Thomas, Charles W. Rittershaus