Patents by Inventor Arthur M. Krieg

Arthur M. Krieg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunostimulatory nucleic acid molecules
    Patent number: 8129351
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: March 6, 2012
    Assignees: The University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Immunomodulatory oligonucleotides
    Patent number: 8114848
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: February 14, 2012
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Nucleic acid compositions for stimulating immune responses
    Patent number: 8114419
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: February 14, 2012
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • ANTI-CTLA-4 AND CPG-MOTIF-CONTAINING SYNTHETIC OLIGODEOXYNUCLEOTIDE COMBINATION THERAPY FOR CANCER TREATMENT
    Publication number: 20120003179
    Abstract: The invention relates to administration of an anti-CTLA-4 antibody, particularly human antibodies to human CTLA-4, such as those having amino acid sequences of antibodies 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1, and MDX-010, in combination with an immunostimulatory nucleotide, i.e., CpG ODN PF3512676, for treatment of cancer. The invention relates to administering a combination of an anti-CTLA-4 antibody and CpG ODN PF3512676 as neoadjuvant, adjuvant, first-line, second-line, and third-line therapy of cancer, whether localized or metastasized, and at any point(s) along the disease continuum (e.g., at any stage of the cancer).
    Type: Application
    Filed: June 24, 2011
    Publication date: January 5, 2012
    Applicants: Coley Pharmaceutical Group, Inc., PFIZER INC
    Inventors: David Robert John READETT, Jarl Ulf Birger Jungnelius, Jesus Gomez-Navarro, Douglas Hanson, Arthur M. Krieg
  • Immunostimulatory nucleic acid molecules
    Patent number: 8058249
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: November 15, 2011
    Assignees: University of Iowa Research Foundation, United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg
  • MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY
    Publication number: 20110244025
    Abstract: The invention provides immunostimulatory compositions and methods for their use. In particular, the immunostimulatory compositions of the invention include RNA-like polymers that incorporate an immunostimulatory sequence motif and at least one chemical modification to confer improved stability against nuclease degradation and improved activity. Specific modifications involving phosphate linkages, nucleotide analogs, and combinations thereof are provided. Compositions of the invention optionally include an antigen and can be used to stimulate an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an to allergic condition, or asthma. Modified oligoribonucleotide analogs of the invention are believed to stimulate Toll-like receptors TLR7 and TLR8.
    Type: Application
    Filed: November 15, 2010
    Publication date: October 6, 2011
    Inventors: Eugen Uhlmann, Arthur M. Krieg, Grayson B. Lipford
  • Methods of treating cancer using immunostimulatory oligonucleotides
    Patent number: 8008266
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: August 30, 2011
    Assignees: University of Iowa Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Alfred D. Steinberg, Dennis Klinman
  • SEMI-SOFT C-CLASS IMMUNOSTIMULATORY OLIGONUCLEOTIDES
    Publication number: 20110201672
    Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
    Type: Application
    Filed: September 14, 2010
    Publication date: August 18, 2011
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann
  • 5? CpG nucleic acids and methods of use
    Patent number: 7956043
    Abstract: The invention relates to a class of CpG immunostimulatory oligonucleotides containing a 5?TCG motif or a CG at or near the 5? end that are useful for stimulating an immune response.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: June 7, 2011
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Arthur M. Krieg, Marion Jurk, Jorg Vollmer, Eugen Uhlmann
  • Immunostimulatory nucleic acid molecules
    Patent number: 7935675
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: May 3, 2011
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • IMMUNOSTIMULATORY NUCLEIC ACID MOLECULES
    Publication number: 20110081366
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Application
    Filed: November 15, 2010
    Publication date: April 7, 2011
    Applicant: University of Iowa Research Foundation
    Inventor: Arthur M. Krieg
  • Methods of using immunostimulatory nucleic acid molecules to treat allergic conditions
    Patent number: 7888327
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: February 15, 2011
    Assignee: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, Joel N. Kline
  • METHODS RELATED TO IMMUNOSTIMULATORY NUCLEIC ACID-INDUCED INTERFERON
    Publication number: 20110033421
    Abstract: Methods and compositions are provided for extending the clinical utility of IFN-? in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-? treatment and reduce IFN-? treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
    Type: Application
    Filed: July 13, 2010
    Publication date: February 10, 2011
    Applicants: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc., University of Iowa Research Foundation
    Inventors: Gunther Hartmann, Robert L. Bratzler, Arthur M. Krieg
  • Immunostimulatory nucleic acid molecules
    Patent number: 7879810
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: February 1, 2011
    Assignees: University of Iowa Research Foundation, The United States of America, as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Nucleic acid compositions for stimulating immune responses
    Patent number: 7807803
    Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: October 5, 2010
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventor: Arthur M. Krieg
  • Semi-soft c-class immunostimulatory oligonucleotides
    Patent number: 7795235
    Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: September 14, 2010
    Assignees: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann
  • Methods related to immunostimulatory nucleic acid-induced interferon
    Patent number: 7776344
    Abstract: Methods and compositions are provided for extending the clinical utility of IFN-? in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-? treatment and reduce IFN-? treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: August 17, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.
    Inventors: Gunther Hartmann, Robert L. Bratzler, Arthur M. Krieg
  • NUCLEIC ACID-LIPOPHILIC CONJUGATES
    Publication number: 20100183639
    Abstract: The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic acid.
    Type: Application
    Filed: November 10, 2009
    Publication date: July 22, 2010
    Applicants: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
    Inventors: Eugen Uhlmann, Jörg Vollmer, Arthur M. Krieg
  • Immunostimulatory nucleic acid molecules
    Patent number: 7723022
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: May 25, 2010
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Immunostimulatory nucleic acid molecules
    Patent number: 7723500
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: May 25, 2010
    Assignees: University of Iowa Research Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
    Inventors: Arthur M. Krieg, Joel Kline, Dennis Klinman, Alfred D. Steinberg